The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Sokolov A.D.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Arakelyan A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Bychenko V.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Asaturova A.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Adamyan L.V.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology;
Russian University of Medicine

Three-dimensional modeling and intraoperative navigation in the diagnosis and treatment of various forms of adenomyosis

Authors:

Sokolov A.D., Arakelyan A.S., Bychenko V.G., Stepanian A.A., Asaturova A.V., Adamyan L.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(2): 92‑100

DOI: 10.17116/repro20253102192

Read: 792 times

Buy for 300₽
Contact the author
Table of contents

THREE-DIMENSIONAL MODELING AND INTRAOPERATIVE NAVIGATION IN THE DIAGNOSIS AND TREATMENT OF VARIOUS FORMS OF ADENOMYOSIS
THREE-DIMENSIONAL MODELING AND INTRAOPERATIVE NAVIGATION IN THE DIAGNOSIS AND TREATMENT OF VARIOUS FORMS OF ADENOMYOSIS

To cite this article:

Sokolov AD, Arakelyan AS, Bychenko VG, Stepanian AA, Asaturova AV, Adamyan LV. Three-dimensional modeling and intraoperative navigation in the diagnosis and treatment of various forms of adenomyosis. Russian Journal of Human Reproduction. 2025;31(2):92‑100. (In Russ.)
https://doi.org/10.17116/repro20253102192

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Type and sex variability of dime­nsional characteristics of the fourth ventricle of the rhomboid brain acco­rding to MRT. Russian Journal of Operative Surgery and Clinical Anatomy. 2024;(4):43-48
Magnetic reso­nance imaging and PET/CT with 11C-methionine for primary central nervous system vasculitis. Burdenko's Journal of Neurosurgery. 2024;(6):71-76
Giant peri­cranial sinus with exte­nsive occi­pital calvarium defect. Burdenko's Journal of Neurosurgery. 2024;(6):77-87
Surgical treatment of asce­nding aortic dissection after previous thoracic endo­vascular aortic repair and proximal stent-graft indu­ced new entry. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(6):682-685
Long-term postoperative outcomes after surgical correction of congenital subaortic stenosis. Piro­gov Russian Journal of Surgery. 2024;(12):60-66
Difficulties in surgical treatment of fixed cardiofundal axial esophageal hiatal hernia. Piro­gov Russian Journal of Surgery. 2024;(12):105-108
Info­rmativeness of various diagnostic methods in inve­rted papi­lloma of the nasal cavity and para­nasal sinu­ses. Russian Rhinology. 2024;(4):269-274
Clinical case of auri­cular gouty tophi. Russian Bulletin of Otorhinolaryngology. 2024;(6):80-84
Evaluation of the impact of a comprehensive reha­bilitation program on improving nutritional status, psychoemotional signs and adve­rse events in patients with mela­noma after surgical treatment. Piro­gov Russian Journal of Surgery. 2024;(12-2):173-178
Features of the prevalence of dege­nerative-dystrophic changes in the cervical spine with a different nature of the course of the vertebral arte­ries. Russian Journal of Operative Surgery and Clinical Anatomy. 2024;(4-2):33-38
Abstract:

OBJECTIVE

Optimization of diagnostic methods for studying the myometrium in adenomyosis using magnetic resonance imaging (MRI) and subsequent construction of a three-dimensional model of the uterus using computer-assisted technologies to optimize surgical treatment.

MATERIAL AND METHODS

An analysis of a comprehensive examination and treatment of 20 patients observed at the Department of Operative Gynecology at the Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology. Two groups of patients were recruited: Group 1 — 10 patients with nodular adenomyosis; Group 2 — 10 patients with diffuse adenomyosis. Concomitant pathology (external genital endometriosis, uterine fibroids, ovarian cysts, adhesions in the pelvis) was detected in 18 of 20 patients. The main complaints of the patients were: pain syndrome, heavy menstrual bleeding, intermenstrual bleeding, history of miscarriage and infertility. The preliminary stage (stage 1) of the study included a standard protocol of gynecological ultrasound examination (US) of the pelvic organs, stage 2 — a protocol for MRI followed by construction of a three-dimensional model of the uterus using computer-assisted technologies and subsequent surgical treatment.

RESULTS

The accuracy of the diagnostic MRI study followed by construction of a three-dimensional model of the uterus is higher than when conducting standard gynecological ultrasound and MRI, which allows for precise selection of treatment tactics for a specific patient, optimization of access to the surgical field, more radical excision of adenomyosis foci with maximum preservation of healthy myometrial tissue using intraoperative navigation, reduction of intraoperative blood loss and improvement of the functional results of the surgical treatment.

CONCLUSION

The obtained data and results can be used now and in the near future in the work of specialists in radiologists, obstetricians and gynecologists, surgeons and oncologists.

Keywords:

adenomyosis
magnetic resonance imaging
3D modeling
surgical treatment

Authors:

Sokolov A.D.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Arakelyan A.S.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Bychenko V.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Asaturova A.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of the Ministry of Healthcare of Russian Federation

Adamyan L.V.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology;
Russian University of Medicine

Received:

17.02.2025

Accepted:

10.03.2025

Close metadata

References:

  1. Senturk LM, Imamoglu M. Adenomyosis: what is new?.Women’s Health. 2015;11(5):717-724.  https://doi.org/10.2217/whe.15.60
  2. Abbott JA. Adenomyosis and Abnormal Uterine Bleeding (AUB-A)-Pathogenesis, diagnosis, and management. Best Practice and Research. Clinical Obstetrics and Gynaecology. 2017;40:68-81.  https://doi.org/10.1016/j.bpobgyn.2016.09.006
  3. Dzhamalutdinova KM, Kozachenko IF, Gus AI, Adamyan LV. Modern aspects of pathogenesis and diagnostics of adenomyosis. Akusherstvo i ginekologiya. 2018;1:29-34. (In Russ.). https://doi.org/10.18565/aig.2018.1.29-34
  4. Mark AS, Hricak H, Heinrichs LW, Hendrickson MR, Winkler ML, Bachica JA, Stickler JE. Adenomyosis and leiomyoma: differential diagnosis with MR imaging. Radiology. 1987;163(2):527-529.  https://doi.org/10.1148/radiology.163.2.3562836
  5. Fedele L, Bianchi S, Dorta M, Arcaini L, Zanotti F, Carinelli S. Transvaginal ultrasonography in the diagnosis of diffuse adenomyosis. Fertility and Sterility. 1992;58(1):94-97. 
  6. Bourdon M, Oliveira J, Marcellin L, Santulli P, Bordonne C, Maitrot Mantelet L, Millischer AE, Plu Bureau G, Chapron C. Adenomyosis of the inner and outer myometrium are associated with different clinical profiles. Human Reproduction. 2021;36(2):349-357.  https://doi.org/10.1093/humrep/deaa307
  7. Bourdon M, Santulli P, Oliveira J, Marcellin L, Maignien C, Melka L, Bordonne C, Millisher AE, Plu-Bureau G, Cormier J, Chapron C. Focal adenomyosis is associated with primary infertility. Fertility and Sterility. 2020;114(6):1271-1277. https://doi.org/10.1016/j.fertnstert.2020.06.018
  8. Tamura H, Kishi H, Kitade M, Asai-Sato M, Tanaka A, Murakami T, Minegishi T, Sugino N. Clinical outcomes of infertility treatment for women with adenomyosis in Japan. Reproductive Medicine and Biology. 2017;16(3):276-282.  https://doi.org/10.1002/rmb2.12036
  9. Kishi Y, Suginami H, Kuramori R, Yabuta M, Suginami R, Taniguchi F. Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification. American Journal of Obstetrics and Gynecology. 2012;207(2):114.e1114.e1147. https://doi.org/10.1016/j.ajog.2012.06.027
  10. Van den Bosch T, Dueholm M, Leone FP, Valentin L, Rasmussen CK, Votino A, Van Schoubroeck D, Landolfo C, Installé AJ, Guerriero S, Exacoustos C, Gordts S, Benacerraf B, D’Hooghe T, De Moor B, Brölmann H, Goldstein S, Epstein E, Bourne T, Timmerman D. Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group. Ultrasound in Obstetrics and Gynecology. 2015;46(3):284-298.  https://doi.org/10.1002/uog.14806
  11. Kepkep K, Tuncay YA, Göynümer G, Tutal E. Transvaginal sonography in the diagnosis of adenomyosis: which findings are most accurate?. Ultrasound in Obstetrics and Gynecology. 2007;30(3):341-345.  https://doi.org/10.1002/uog.3985
  12. Sencha AN, Kondratovich LM, Bykov AG, Adamyan LV. Ultrasound elastography in the diagnosis of adenomyosis. Akusherstvo i ginekologiya. 2020;3:86-99. (In Russ.). https://doi.org/10.18565/aig.2020.3.86-99
  13. Shklyar AA, Adamyan LV, Kogan EA, Paramonova NB, Kozachenko IF, Gavrilova TYu, Kononov SN. Difficulties in diagnosing nodular and diffuse adenomyosis. Akusherstvo i ginekologiya. 2015;3:67-72. (In Russ.).
  14. Sencha AN, Arakelyan AS, Bykov AG, Adamyan LV. Contrast-enhanced ultrasound imaging in the diagnosis of adenomyosis. Akusherstvo i ginekologiya. 2021;6:115-121. (In Russ.).
  15. Habiba M, Benagiano G. Classifying Adenomyosis: Progress and Challenges. International Journal of Environmental Research and Public Health. 2021;18(23):12386. https://doi.org/10.3390/ijerph182312386
  16. Kishi Y, Suginami H, Kuramori R, Yabuta M, Suginami R, Taniguchi F. Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification. American Journal of Obstetrics and Gynecology. 2012;207(2):114.e1114.e1147. https://doi.org/10.1016/j.ajog.2012.06.027
  17. Bazot M, Daraï E. Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis. Fertility and Sterility. 2018;109(3):389-397.  https://doi.org/10.1016/j.fertnstert.2018.01.024
  18. Chapron C, Tosti C, Marcellin L, Bourdon M, Lafay-Pillet MC, Millischer AE, Streuli I, Borghese B, Petraglia F, Santulli P. Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. Human Reproduction. 2017;32(7):1393-1401. https://doi.org/10.1093/humrep/dex088
  19. Adamyan LV, Kulakov VI. Endometriozy. M.: Meditsina; 1998. (In Russ.).
  20. Reinhold C, McCarthy S, Bret PM, Mehio A, Atri M, Zakarian R, Glaude Y, Liang L, Seymour RJ. Diffuse adenomyosis: comparison of endovaginal US and MR imaging with histopathologic correlation. Radiology. 1996;199(1):151-158.  https://doi.org/10.1148/radiology.199.1.8633139
  21. Arakelyan AS, Gus AI, Adamyan LV, Popryadukhin AYu, Boykova YuV. The role of 3D echographic diagnostics in the choice of tactics for reconstructive plastic surgery in case of abnormalities of the development of the uterus and vagina. Russian Journal of Human Reproduction. 2021;27(4):32-42. (In Russ.). https://doi.org/10.17116/repro20212704132
  22. Marmulla R, Niederdellmann H. Computer-assisted bone segment navigation. Journal of Cranio-Maxillo-Facial Surgery.1998;26(6): 347-359.  https://doi.org/10.1016/s1010-5182(98)80067-x
  23. Shchadenko SV, Gorbyachova AS, Arslanova AR, Tolmachyov IV. 3D visualization for surgical modelling and surgical planning. Byulleten’ sibirskoj meditsiny. 2014;13(4):165-171. (In Russ.).
  24. Tejo-Otero A, Buj-Corral I, Fenollosa-Artés F. 3D Printing in Medicine for Preoperative Surgical Planning: A Review. Annals of Biomedical Engineering. 2020;48(2):536-555.  https://doi.org/10.1007/s10439-019-02411-0
  25. Fedorov VD, Karmazanovskiy GG, Guzeeva EB, Tsvirkun VV. Virtual’noe khirurgicheskoe modelirovanie na osnove dannykh komp’yuternoj tomografii. M.: Vidar; 2003. (In Russ.).
  26. Sabri SA, York PJ. Preoperative planning for intraoperative navigation guidance. Annals of Translational Medicine. 2021;9(1):87.  https://doi.org/10.21037/atm-20-1369
  27. Baldwin KD, Kadiyala M, Talwar D, Sankar WN, Flynn JJM, Anari JB. Does intraoperative CT navigation increase the accuracy of pedicle screw placement in pediatric spinal deformity surgery? A systematic review and meta-analysis. Spine Deformity. 2022; 10(1):19-29.  https://doi.org/10.1007/s43390-021-00385-5
  28. Kimmig R, Aktas B, Buderath P, Rusch P, Heubner M. Intraoperative navigation in robotically assisted compartmental surgery of uterine cancer by visualisation of embryologically derived lymphatic networks with indocyanine-green (ICG). Journal of Surgical Oncology. 2016;113(5):554-559.  https://doi.org/10.1002/jso.24174
  29. Shi J, Wu Y, Li X, Gu Z, Zhang C, Yan H, Dai Y, Leng J. Effects of localization of uterine adenomyosis on clinical features and pregnancy outcome. Scientific Reports. 2023;13(1):14714. https://doi.org/10.1038/s41598-023-40816-z
  30. Ajao MO, Clark NV, Kelil T, Cohen SL, Einarsson JI. Case Report: Three-Dimensional Printed Model for Deep Infiltrating Endometriosis. Journal of Minimally Invasive Gynecology. 2017;24(7): 1239-1242. https://doi.org/10.1016/j.jmig.2017.06.006
  31. Mackey A, Ng JI, Core J, Nguyen L, Cross D, Lim P, Woodfield C, Pugliese R, Ku B. Three-Dimensional-Printed Uterine Model for Surgical Planning of a Cesarean Delivery Complicated by Multiple Myomas. Obstetrics and Gynecology, 2019;133(4):720-724.  https://doi.org/10.1097/AOG.0000000000003107
  • Tejada MA, Antunez C, Nunez-Badinez P, De Leo B, Saunders PT, Vincent K, Cano A, Nagel J, Gomez R. Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis. International Journal of Molecular Sciences. 2023;24(3):2422. https://doi.org/10.3390/ijms2403242
  • Deseure K, Hans GH. Chronic Constriction Injury of the Rat’s Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain. Journal of Visualized Experiments. 2015;(103):53167. https://doi.org/10.3791/53167
  • Cordaro M, Trovato Salinaro A, Siracusa R, D\’Amico R, Impellizzeri D, Scuto M, Ontario ML, Interdonato L, Crea R, Fusco R, Cuzzocrea S, Di Paola R, Calabrese V. Hidrox® and Endometriosis: Biochemical Evaluation of Oxidative Stress and Pain. Antioxidants. 2021;10(5):720.  https://doi.org/10.3390/antiox10050720
  • Tejada MA, Santos-Llamas AI, Escriva L, Tarin JJ, Cano A, Fernández-Ramírez MJ, Nunez-Badinez P, De Leo B, Saunders PTK, Vidal V, Barthas F, Vincent K, Sweeney PJ, Sillito RR, Armstrong JD, Nagel J, Gomez R. Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain. Biomedicines. 2022;10(2):501.  https://doi.org/10.3390/biomedicines10020501
  • Pattison LA, Cloake A, Chakrabarti S, Hilton H, Rickman RH, Higham JP, Meng MY, Paine LW, Dannawi M, Qiu L, Ritoux A, Bulmer DC, Callejo G, Smith ESJ. Digging deeper into pain — an ethological behavior assay correlating well-being in mice with human pain experience. Pain. 2024;165(8):1761-1773. https://doi.org/10.1101/2023.08.18.553862
  • Leung VSY, Benoit-Biancamano MO, Pang DSJ. Performance of behavioral assays: the Rat Grimace Scale, burrowing activity and a composite behavior score to identify visceral pain in an acute and chronic colitis model. Pain Reports. 2019;4(2):e718. https://doi.org/10.1097/PR9.0000000000000712
  • Persoons E, De Clercq K, Van den Eynde C, Pinto SJPC, Luyten K, Van Bree R, Tomassetti C, Voets T, Vriens J. Mimicking Sampson’s Retrograde Menstrual Theory in Rats: A New Rat Model for Ongoing Endometriosis-Associated Pain. International Journal of Molecular Sciences. 2020;21(7):2326. https://doi.org/10.3390/ijms21072326
    • Contact the author
    Email
    Message
    The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

    Email Confirmation

    An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

    Email Confirmation

    Contact us
    If you have any questions, complaints or suggestions, please use this feedback form.
    Email
    Message
    The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
    Submit Application

    You can become an author of one of our magazines, send a request and we will consider it in during the day.

    Name
    Phone
    E-mail
    Message
    Login
    Registration
    E-mail
    Password
    Forgot Password?

    Log in to the site using your account in one of the services

    Password recovery
    E-mail
    Login
    Register

    We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.