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Kovrazhkina E.A.

Federal Center for Brain and Neurotechnology

Serdyuk A.V.

Pirogov Russian National Research Medical University

Razinskaya O.D.

Pirogov Russian National Research Medical University

Shurdumova M.H.

Pirogov Russian National Research Medical University;
Moscow City Clinical Hospital No. 31

Vyatkina N.V.

Moscow City Clinical Hospital No. 31

Baranova E.A.

Federal Center for Brain and Neurotechnology;
Kazan State Medical Academy

Myasthenic syndrome in a patient with end-stage amyotrophic lateral sclerosis

Authors:

Kovrazhkina E.A., Serdyuk A.V., Razinskaya O.D., Shurdumova M.H., Vyatkina N.V., Baranova E.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(7): 102‑107

DOI: 10.17116/jnevro2023123071102

Views: 2084

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Table of contents

MYASTHENIC SYNDROME IN A PATIENT WITH END-STAGE AMYOTROPHIC LATERAL SCLEROSIS
MYASTHENIC SYNDROME IN A PATIENT WITH END-STAGE AMYOTROPHIC LATERAL SCLEROSIS

To cite this article:

Kovrazhkina EA, Serdyuk AV, Razinskaya OD, Shurdumova MH, Vyatkina NV, Baranova EA. Myasthenic syndrome in a patient with end-stage amyotrophic lateral sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(7):102‑107. (In Russ.)
https://doi.org/10.17116/jnevro2023123071102

 
 
Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Amyotrophic lateral sclerosis (ALS) and myasthenia gravis are diseases with similar clinical features but different prognosis and approach to treatment. It is possible as an extremely rare combination of these diseases, as well as myasthenia gravis with signs of ALS (MuSK-positive), as well as ALS, accompanied by myasthenic syndrome. Latter option is the most common. Myasthenic syndrome accompanying the ALS characterized by pathological muscle fatigue signs, symptoms variability during the day, partial sensitivity to neostigmine, M-wave decrements detection during electromyographyc study. We present a case of a patient with terminal ALS and myasthenic syndrome. The main pathogenesis theories of this condition and the differential diagnosis of ALS and myasthenia gravis are discussed.

Keywords:

amyotrophic lateral sclerosis
myasthenia
electromyographyc study
differential diagnosis

Authors:

Kovrazhkina E.A.

Federal Center for Brain and Neurotechnology

Serdyuk A.V.

Pirogov Russian National Research Medical University

Razinskaya O.D.

Pirogov Russian National Research Medical University

Shurdumova M.H.

Pirogov Russian National Research Medical University;
Moscow City Clinical Hospital No. 31

Vyatkina N.V.

Moscow City Clinical Hospital No. 31

Baranova E.A.

Federal Center for Brain and Neurotechnology;
Kazan State Medical Academy

Received:

10.02.2023

Accepted:

10.04.2023

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