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Kozlova A.O.

Research center of Neurology

Kamenskikh E.M.

Siberian State Medical University

Konovalov R.N.

Research Center of Neurology

Chekanova E.O.

Research Center of Neurology

Alifirova V.M.

Siberian State Medical University

Zakharova M.N.

Research Center of Neurology

«Masks» of CNS demyelinating diseases. Primary lymphoma

Authors:

Kozlova A.O., Kamenskikh E.M., Konovalov R.N., Chekanova E.O., Alifirova V.M., Zakharova M.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(7‑2): 101‑108

DOI: 10.17116/jnevro2024124072101

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Table of contents

«MASKS» OF CNS DEMYELINATING DISEASES. PRIMARY LYMPHOMA
«MASKS» OF CNS DEMYELINATING DISEASES. PRIMARY LYMPHOMA

To cite this article:

Kozlova AO, Kamenskikh EM, Konovalov RN, Chekanova EO, Alifirova VM, Zakharova MN. «Masks» of CNS demyelinating diseases. Primary lymphoma. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(7‑2):101‑108. (In Russ.)
https://doi.org/10.17116/jnevro2024124072101

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Primary central nervous system lymphoma (PCNSL) is a rare neoplasm that can affect the brain, eyes, and, rarely, the spinal cord. Clinical presentation and MRI findings can mimic a variety of diseases, including high-grade gliomas, infectious and granulomatous diseases, and demyelinating diseases. We describe three cases where the diagnosis of PCNSL was difficult due to an ambiguous clinical, radiological and laboratory results. The role of stereotactic biopsy remains leading in differential diagnosis; however, the invasiveness and frequent limitations of this method determine the search for additional biological markers of the disease. New evidence suggests a potential role for cerebrospinal fluid (CSF) cytokine profiles and proteomic analysis in differential diagnosis, disease progression, and treatment response.

Keywords:

Primary central nervous system lymphoma
differential diagnosis
demyelination
autoimmune diseases

Authors:

Kozlova A.O.

Research center of Neurology

Kamenskikh E.M.

Siberian State Medical University

Konovalov R.N.

Research Center of Neurology

Chekanova E.O.

Research Center of Neurology

Alifirova V.M.

Siberian State Medical University

Zakharova M.N.

Research Center of Neurology

Received:

16.05.2024

Accepted:

13.06.2024

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