Results of a multicenter observational program to evaluate the effectiveness of complex therapy of patients with chronic cerebrovascular pathology with cognitive impairment with Cortexin and Neuromexol (CORNELia study)

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OBJECTIVE

To evaluate the effectiveness of complex therapy with Cortexin and Neuromexol in patients with chronic cerebral ischemia (CCI) and cognitive impairment (CI).

MATERIAL AND METHODS

We examined 801 patients with CCI on the background of arterial hypertension and atherosclerosis with confirmed CI: 329 (41.1%) men and 472 (58.9%) women aged 30 to 80 years (mean age 64±10 years), who were examined. Cortexin and Neuromexol. Examination — Mini-Mental State Examination (MMSE) scale, hour-long drawing test (HDT) and severity of depressive states (Brief Geriatric Depression Scale, Mini Geriatric Depression Scal, MGDS). In 30 patients receiving Cortexin and Neuromexol (main group, MG) and 30 patients in the comparison group (CG), biomarkers of ischemic brain damage (NSE, antibodies to NR2, VEGFA) were determined. The examination was carried out before the start of treatment and after 30 days.

RESULTS

During therapy with Cortexin and Neuromexol, characteristic signs of a decrease in the severity of CI were noted (p<0.05). A positive correlation was revealed between the performance indicators of the MMSE and TFC tests, both before and after treatment (r=0.5 and r=0.6, respectively; p<0.05). A positive effect of therapy on the emotional background of patients was noted, in particular, a decrease in the severity of depressive symptoms on the MGDS scale. During therapy, a 2-fold decrease in the NSE level (p<0.05) was detected in the MG, which indicates a decrease in the structural and functional parameters of biomembrane neurons in the brain. The concentration of antibodies to NR2 decreased compared to the baseline level in both groups (p<0.05), and VEGFA decreased only in the MG (p<0.05).

CONCLUSION

The results of the study allow us to recommend the complex prescription of Cortexin 10 mg/day for 10 days and Neuromexol tablets 125 mg (375-750 mg/day) for 30 days for chronic CVD. Complex therapy with Cortexin and Neuromexol is effective and safe in patients with CCI and CI

Keywords:

dyscirculatory encephalopathy

cerebrovascular diseases

cognitive impairment

Cortexin

Neuromexol

Authors:

Mashin V.V.

Ulyanovsk State University

ORCID: 0000-0003-0085-3727

Belova L.A.

Ulyanovsk State University

ORCID: 0000-0002-9585-5604

Kotova E.Y.

Ulyanovsk State University

ORCID: 0009-0004-2293-3183

Dolgova D.R.

Ulyanovsk State University

ORCID: 0000-0001-5475-7031

Statenina A.P.

Ulyanovsk State University

ORCID: 0009-0007-0834-2012

Belyaeva Y.K.

Ulyanovsk State University

ORCID: 0009-0005-5045-8866

Dergacheva A.S.

Ulyanovsk State University

ORCID: 0009-0002-7351-7134

Israfilova R.R.

Ulyanovsk State University

ORCID: 0009-0000-5502-3961

Received:

13.10.2023

Accepted:

11.11.2023

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