Features of cognitive impairment in bipolar affective disorder

Close metadata

Recommended articles:

Modern ideas about the relationship between fibromyalgia and mental disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(10):7-16

Pathogenetic therapy of cognitive impairment: results of a multicenter placebo-controlled clinical trial of the efficacy and safety of Miladean. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(10):60-68

Observational study of the efficacy and safety of the drug Ampasse in patients with moderate cognitive impairment in chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(10):75-80

Therapy of asthenic disorders after psychotic conditions in patients with cognitive impairment: results of an observational non-interventional program. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(10):81-87

Arterial hypertension and cognitive impairment. Neurologist’s view. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(11):7-13

Recognan (citicoline) efficacy and safety in cognitive impairment correction of various nosological forms. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(11):22-28

Psychopathological correlates of depression with non-suicidal self-harm in non-psychotic mental illnesses of adolescence. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(11-2):74-78

Comorbidity patterns and structure of depressive episodes in patients with bipolar disorder and major depressive disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(11-2):108-114

Nimodipine in treatment of bipolar disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(12):20-26

Algorithm of allergic rhinitis treatment in patients with various types of nasal septum deviation. Russian Rhinology. 2023;(4):238-244

The study of cognitive impairment in bipolar disorder (BD) combined with anxiety-phobic disorders, as the most common comorbid pathology, is a new, little-studied and relevant direction for further research on BD, promising for clarifying the neurobiological mechanisms of the disease and improving the quality of the diagnostic process. By searching for combinations of the keywords «bipolar disorder», «anxiety disorders», «cognitive impairment», «cognitive dysfunction», «meta-analysis» and «review» in the databases «PubMed» and «Google Scholar», meta-analyses, analytical, review and original relevant research articles were identified. A generalization of the information accumulated in the literature indicates a) the presence in BD of both phase-dependent and persistent cognitive impairments that also occur during the period of euthymia, b) different structure and severity of neurocognitive disorders in cases of «pure» BD and anxiety-phobic disorders, c) the unique structure of cognitive impairment in BD with comorbid anxiety-phobic disorders, which incorporates the features of neurocognitive impairments that are characteristic of both disorders and have the greatest severity compared to them. The results of this review are of interest for planning further empirical studies of this topic on the Russian patient population.

Keywords:

bipolar affective disorder

cognitive impairment

neuropsychology

anxiety-phobic disorders

comorbidity

Authors:

Gornushenkov I.D.

Mental Health Research Center of the Russian Academy of Medical Sciences

ORCID: 0000-0002-7718-1626

Kulikova V.S.

Mental Health Research Center of the Russian Academy of Medical Sciences

ORCID: 0000-0002-8894-3825

Pluzhnikov I.V.

Mental Health Research Center of the Russian Academy of Medical Sciences

ORCID: 0000-0002-6323-0976

Barkhatova A.N.

Mental Health Research Center

ORCID: 0000-0003-3805-332X

Alekseeva A.G.

Mental Health Research Center

ORCID: 0000-0001-7283-1717

Received:

05.03.2024

Accepted:

15.03.2024

List of references:

Ferrier IN, Thompson JM. Cognitive impairment in bipolar affective disorder: Implications for the bipolar diathesis. Br J Psychiatry. 2002;180(APR.):293-295. https://doi.org/10.1192/bjp.180.4.293
Shipkova KM, Dovzhenko TV. Neurocognitive correlates of bipolar affective disorders. Rossiiskii Psikhiatricheskii Zhurnal. 2022;(5):30-38. (In Russ.).
Bora E, Pantelis C. Meta-analysis of cognitive impairment in first-episode bipolar disorder: Comparison with first-episode schizophrenia and healthy controls. Schizophr Bull. 2015;41(5):1095-1104. https://doi.org/10.1093/schbul/sbu198
Depp CA, Mausbach BT, Harmell AL, et al. Meta-analysis of the association between cognitive abilities and everyday functioning in bipolar disorder. Bipolar Disord. 2012;14(3):217-226. https://doi.org/10.1111/j.1399-5618.2012.01011.x
Konoreva AE, Mosolov SN. Cognitive Impairment in Bipolar Affective Disorder. Sovrem. Ter. Psih. Rasstrojstv. 2017;(4):11-18. (In Russ.). https://doi.org/10.21265/PSYPH.2017.43.8416
MacKinnon DF, Zamoiski R. Panic comorbidity with bipolar disorder: What is the manic-panic connection? Bipolar Disord. 2006;8(6):648-664. https://doi.org/10.1111/j.1399-5618.2006.00356.x
Petrova NN. To the question of co-occurrence of bipolar affective disorder and anxiety. Sotsial’naya i Klinicheskaya Psikhiatriya. 2016;26(2):106-110. (In Russ.).
Vasilieva SN, Simutkin GG, Schastnyy ED. Clinical and dynamic characteristics of bipolar affective disorder in comorbidity with other mental disorders. Sibirskii Vestnik psikhiatrii i Narkologii. 2017;2(95):16-20. (In Russ.).
Spoorthy MS, Chakrabarti S, Grover S. Comorbidity of bipolar and anxiety disorders: An overview of trends in research. World J Psychiatry. 2019;9(1):7-29. https://doi.org/10.5498/wjp.v9.i1.7
MacKinnon DF, Xu J, McMahon FJ, et al. Bipolar disorder and panic disorder in families: An analysis of chromosome 18 data. Am J Psychiatry. 1998;155(6):829-831.
Tanahashi S, Tanii H, Konishi Y, et al. Association of Serotonin Transporter Gene (5-HTTLPR/rs25531) Polymorphism with Comorbidities of Panic Disorder. Neuropsychobiology. 2021;80(4):333-341. https://doi.org/10.1159/000512699
Bourne C, Aydemir O, Balanzá-Martínez V, et al. Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: An individual patient data meta-analysis. Acta Psychiatr Scand. 2013;128(3):149-162. https://doi.org/10.1111/acps.12133
Robinson LJ, Thompson JM, Gallagher P, et al. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord. 2006;93(1-3):105-115. https://doi.org/10.1016/j.jad.2006.02.016
Bora E, Yücel M, Pantelis C. Cognitive impairment in affective psychoses: A meta-analysis. Schizophr Bull. 2010;36(1):112-125. https://doi.org/10.1093/schbul/sbp093
Verbenko GN. The specific of cognitive imparement in patients with bipolar disorder. Taurida Journal of Psychiatry. 2014;1(66):18-23. (In Russ.).
Chumakov EM, Petrova NN, Limankin OV, Ashenbrenner YuV. Cognitive impairment in remitted patients with bipolar disorder. S.S. Korsakov Journal of Neurologiy and Psychiatry. 2021;121(4):12-18. (In Russ.). https://doi.org/10.17116/jnevro202112104112
Airaksinen E, Larsson M, Forsell Y. Neuropsychological functions in anxiety disorders in population-based samples: Evidence of episodic memory dysfunction. J Psychiatr Res. 2005;39(2):207-214. https://doi.org/10.1016/j.jpsychires.2004.06.001
Castaneda AE, Tuulio-Henriksson A, Marttunen M, et al. A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults. J Affect Disord. 2008;106(1-2):1-27. https://doi.org/10.1016/j.jad.2007.06.006
Lautenbacher S, Spernal J, Krieg JC. Divided and selective attention in panic disorder: A comparative study of patients with panic disorder, major depression and healthy controls. Eur Arch Psychiatry Clin Neurosci. 2002;252(5):210-213. https://doi.org/10.1007/s00406-002-0382-5
Asmundson GJG, Stein MB, Larsen DK, et al. Neurocognitive function in panic disorder and social phobia patients. Anxiety. 1994;1(5):201-207. https://doi.org/10.1002/anxi.3070010503
O’Sullivan K, Newman EF. Neuropsychological impairments in panic disorder: A systematic review. J Affect Disord. 2014;167:268-284. https://doi.org/10.1016/j.jad.2014.06.024
Lucas JA, Telch MJ, Bigler ED. Memory functioning in panic disorder: A neuropsychological perspective. J Anxiety Disord. 1991;5(1):1-20. https://doi.org/10.1016/0887-6185(91)90013-J
Boldrini M, Del Pace L, Placidi GPA, et al. Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. Acta Psychiatr Scand. 2005;111(2):150-158. https://doi.org/10.1111/j.1600-0447.2004.00247.x
Cavedini P, Riboldi G, D’annucci A, et al. Decision-making heterogeneity in obsessive-compulsive disorder: Ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia. 2002;40(2):205-211. https://doi.org/10.1016/S0028-3932(01)00077-X
Giomi S, Siri F, Ferro A, et al. Executive Functions in panic disorder: A mini-review. J Affect Disord. 2021;288:107-113. https://doi.org/10.1016/j.jad.2021.03.084
Harber L, Hamidian R, Bani-Fatemi A, et al. Meta-Analysis of Neuropsychological Studies in Panic Disorder Patients: Evidence of Impaired Performance during the Emotional Stroop Task. Neuropsychobiology. 2019;78(1):7-13. https://doi.org/10.1159/000496623
Cohen LJ, Hollander E, DeCaria CM, et al. Specificity of neuropsychological impairment in obsessive-compulsive disorder: A comparison with social phobic and normal control subjects. J Neuropsychiatry Clin Neurosci. 1996;8(1):82-85. https://doi.org/10.1176/jnp.8.1.82
Zalewski C, Thompson W, Gottesman I. Comparison of Neuropsychological test performance in ptsd, generalized anxiety disorder, and control vietnam veterans. Assessment. 1994;1(2):133-142. https://doi.org/10.1177/1073191194001002003
Langarita-Llorente R, Gracia-García P. Neuropsychology of generalized anxiety disorders: A systematic review. Rev Neurol. 2019;69(2):59-67. https://doi.org/10.33588/rn.6902.2018371
Gkintoni E, Ortiz PS. Neuropsychology of Generalized Anxiety Disorder in Clinical Setting: A Systematic Evaluation. Healthc. 2023;11(17):24-46. https://doi.org/10.3390/healthcare11172446
Leonard K, Abramovitch A. Cognitive functions in young adults with generalized anxiety disorder. Eur Psychiatry. 2019;56:1-7. https://doi.org/10.1016/j.eurpsy.2018.10.008
Çörekçioğlu S, Cesur E, Devrim Balaban Ö. Relationship between impulsivity, comorbid anxiety and neurocognitive functions in bipolar disorder. Int J Psychiatry Clin Pract. 2021;25(1):62-72. https://doi.org/10.1080/13651501.2020.1833040
Wu HI, Chang YH, Lai CC, et al. The effect of comorbid anxiety disorder on neuropsychological function in bipolar II disorder. Prog Neuro-Psychopharmacology Biol Psychiatry. 2011;35(8):1841-1845. https://doi.org/10.1016/j.pnpbp.2011.07.013
Chang CT, Chang YH, Yung-Wei Wu J, et al. Neuropsychological functions impairment in different subtypes of bipolar disorder with or without comorbid anxiety disorders. Psychiatry Res. 2012;200(2-3):246-251. https://doi.org/10.1016/j.psychres.2012.06.012

Close metadata