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Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Cognitive impairment in post-traumatic stress disorder

Authors:

Bogolepova A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5): 69‑74

DOI: 10.17116/jnevro202412405169

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To cite this article:

Bogolepova AN. Cognitive impairment in post-traumatic stress disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5):69‑74. (In Russ.)
https://doi.org/10.17116/jnevro202412405169

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Post-traumatic stress disorder (PTSD) is a common mental health disorder, with an incidence of up to 12.5% among primary care patients. Most often, PTSD is detected in combat veterans, victims of terrorist attacks and terror, but it can also be a consequence of traumatic brain injury and medical interventions. Impaired cognitive functioning is a key feature of PTSD, including attention deficits and reduced processing speed, executive dysfunction, and impairments in verbal learning and memory. Cognitive impairments in PTSD are significantly persistent and are largely similar in nature to neuropsychological impairments in neurodegenerative pathology. Possible pathogenetic mechanisms underlying PTSD are the development of neuroinflammation, oxidative stress and decreased production of neurotrophic factors. One of the promising areas of treatment is the use of Cerebrolysin, which has powerful neurotrophic and anti-inflammatory activity.

Keywords:

cognitive impairment
post-traumatic stress disorder
neuroinflammation
oxidative stress
Cerebrolysin

Authors:

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Received:

09.04.2024

Accepted:

10.04.2024

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