The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Burd S.G.

Pirogov Russian National Research Medical University;
Federal center of brain research and neurotechnologies

Lebedeva A.V.

Pirogov Russian National Research Medical University;
Scientific Research Institute of Healthcare Organization and Medical Managemen

Avakyan G.G.

Pirogov Russian National Research Medical University

Rubleva Yu.V.

Federal center of brain research and neurotechnologies

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Yurchenko A.V.

Federal Center of Brain Research and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain Research and Neurotechnologies

COVID-19-associated damage of the peripheral nervous system

Authors:

Burd S.G., Lebedeva A.V., Avakyan G.G., Rubleva Yu.V., Pantina N.V., Yurchenko A.V., Kovaleva I.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(9): 15‑21

DOI: 10.17116/jnevro202212209115

Views: 4227

Downloaded: 126

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Burd SG, Lebedeva AV, Avakyan GG, Rubleva YuV, Pantina NV, Yurchenko AV, Kovaleva II. COVID-19-associated damage of the peripheral nervous system. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(9):15‑21. (In Russ.)
https://doi.org/10.17116/jnevro202212209115

 
МСФ на ЯМ
Close metadata
Recommended articles:
Trends in the inci­dence of mental and beha­vioral diso­rders during the COVID-19 pandemic in Penza Oblast. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(2):129-134
A clinical case of the new-onset bipo­lar affe­ctive diso­rder in the postcovid period. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):125-129
COVID-19 in medi­cal workers: social demo­graphic and clinical features in the examination of the correlation between the disease and an occu­pation. Russian Journal of Preventive Medi­cine. 2024;(2):30-36
A clinical case of the pulmonary arte­ries thro­mbosis complicated by infa­rct-pneumonia in the patient unde­rwent the SARS-CoV-2. Russian Journal of Preventive Medi­cine. 2024;(2):92-95
Analytical review of respiratory infe­ctions role in patients with chro­nic obstructive pulmonary disease and asthma. Part 2. Prevention of occu­rrence and severe course of respiratory infe­ctions. Russian Journal of Preventive Medi­cine. 2024;(2):103-110
Causes of hospital mortality in adults based on medi­cal certificates of death. Russian Journal of Preventive Medi­cine. 2024;(3):7-13
Anti­biotic resi­stance of the upper respiratory tract microbiota in children with the new coro­navirus infe­ction in Ryazan. Russian Journal of Preventive Medi­cine. 2024;(3):45-51
Comparison of the clinical performance of immu­nochromatographic tests for the dete­ction of SARS-CoV-2 anti­gens with data from inde­pendent studies. Labo­ratory Service. 2024;(1):13-19
Adve­rse peri­natal outcomes in COVID-19. Analysis of a series of clinical obse­rvations. Russian Bulletin of Obstetrician-Gynecologist. 2024;(2):86-90
Staging of COVID-19 morphological mani­festations in lungs depe­nding on disease dura­tion. Fore­nsic Medi­cal Expe­rtise. 2024;(2):28-31

Based on the available literature data, the article discusses the prevalence of various forms of damage of the peripheral nervous system in COVID-19 and in the post-COVID period. Information about the clinical features and the course of individual cranial neuropathies, chronic dysimmune neuropathies, Guillain—Barré syndrome, drug-induced neuropathies, fine fiber neuropathy, myasthenia gravis and polyneuropathy of critical conditions was systemized in the context of coronavirus infection. SARS-CoV-2 can trigger various stages of pathogenesis, including neuroimmune ones, which cause long-term consequences of COVID-19, including those associated with the damage of the peripheral nervous system. Awareness of COVID-19-associated pathological conditions will allow assessment of the possible risks of damage of the peripheral nervous system, recognize them at early stages and develop more effective approaches for treatment.

Keywords:

coronavirus infection
COVID-19
SARS-CoV-2
post-COVID syndrome
peripheral nervous system

Authors:

Burd S.G.

Pirogov Russian National Research Medical University;
Federal center of brain research and neurotechnologies

Lebedeva A.V.

Pirogov Russian National Research Medical University;
Scientific Research Institute of Healthcare Organization and Medical Managemen

Avakyan G.G.

Pirogov Russian National Research Medical University

Rubleva Yu.V.

Federal center of brain research and neurotechnologies

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Yurchenko A.V.

Federal Center of Brain Research and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain Research and Neurotechnologies

Received:

27.04.2022

Accepted:

18.05.2022

List of references:

  1. Paterson RW, Brown RL, Benjamin L, et al.The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020;143(10):3104-3120. https://doi.org/10.1093/brain/awaa240
  2. Andalib S, Biller J, Di Napoli M, et al. Peripheral Nervous System ManifestationsAssociated with COVID-19. Curr Neurol Neurosci Rep. 2021;21(3):9.  https://doi.org/10.1007/s11910-021-01102-5
  3. Rifino N, Censori B, Agazzi E, et al. Neurologic manifestations in 1760COVID‐19 patients admitted to Papa Giovanni XXIII Hospital, Ber-gamo, Italy. J Neurol. 2021;268(7):2331‐2338. https://doi.org/10.1007/s00415‐020‐10251‐5
  4. Varatharaj A, Thomas N, Ellul MA, et al. Neurological and neuropsy-chiatric complications of COVID‐19 in 153 patients: a UK‐wide sur-veillance study. Lancet Psychiatry. 2020;7:875‐882.  https://doi.org/10.1016/S2215‐0366(20)30287‐X
  5. Dolgopolov IS, Mentkevich GL, Rykov MY, Chichanovskaya LV. Neurological disorders in patients with long COVID syndrome and cell therapy methods for their correction: a literature review. Sechenov Medical Journal. 2021;(12):3. (In Russ.). https://doi.org/10.47093/2218-7332.2021.12.3.56-67
  6. Belopasov VV, Zhuravleva EN, Nugmanova NP, Abdrashitova AT. Post-covid-19 neurological syndromes. Journal of Clinical Practice. 2021;12(2):69-82. (In Russ.) https://doi.org/10.17816/clinpract71137
  7. Belopasov VV, Yachou Y, Samoilova EM, Baklaushev VP. The nervous system damage in COVID-19. Journal of Clinical Practice. 2020;11(2):60-80. (In Russ.). https://doi.org/10.17816/clinpract34851
  8. Khrulev AE, Shiyanova NA, Sorokoumova SN, et al. Acute and chronic dysimmune polyneuropathies in the context of the COVID 19 pandemic: pathogenesis, features of the clinical picture, diagnosis and therapy (litera ture review). Nervno Myshechnye Bolezni = Neuromuscular Diseases. 2021;11(2):17-27. (In Russ). https://doi.org/10.17650/2222 8721 2021 11 2 17 27
  9. Stefanou M-I, Palaiodimou L, Bakolaet E, et al. Neurological manifestations of long-COVID syndrome: a narrative review. Therapeutic Advances in Chronic Disease. February 2022. https://doi.org/10.1177/20406223221076890
  10. Maksimova MYu, Grusha YaO, Fettser EI. COVID-19 associated multiple cranial neuropathies. Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2022;14(1):99-103. (In Russ.). https://doi.org/10.14412/2074-2711-2022-1-99-103
  11. Finsterer J, Scorza FA, Scorza C, Fiorini A. COVID-19 associated cranial nerve neuropathy: A systematic review. Bosn J Basic Med Sci. 2021 Aug 11.  https://doi.org/10.17305/bjbms.2021.6341
  12. Arens T, Giuseppe L. COVID-19 and the Peripheral Nervous System. A 2-year review from the pandemic to the vaccine era. J Peripher Nerv Syst. 2022;27(1):4-30.  https://doi.org/10.1111/jns.12482
  13. Sharifian-Dorche M, Huot P, Osherov M, et al. Neurological complications of coronavirusinfection; a comparative review and lessons learned during the COVID-19 pandemic. J Neurol Sci. 2020;417:117085. https://doi.org/10.1016/j.jns.2020.117085
  14. Rodrigo‐Armenteros P, Uterga‐Valiente JM, Zabala‐del‐Arco J, et al. Optic neuropathy in a patient with COVID‐19 infection. Acta Neurol Belg. 2021;21(6):1-3.  https://doi.org/10.1007/s13760‐021‐01600‐w
  15. François J, Collery AS, Hayek G, et al. Coronavirus disease2019‐associ-ated ocular neuropathy with panuveitis: a case report. JAMA Ophthalmol. 2021;139:247‐249.  https://doi.org/10.1001/jamaophthalmol.2020.5695
  16. Lima MA, Silva MTT, Soares CN, et al. Peripheral facialnerve palsy associated with COVID-19. J Neurovirol. 2020;26(6):941-944. Epub 2020 Oct 2.  https://doi.org/10.1007/s13365-020-00912-6
  17. Codeluppi L, Venturelli F, Rossi J, et al. Facial palsy during theCOVID‐19 pandemic. Brain Behav. 2021;11:e01939. https://doi.org/10.1002/brb3.1939
  18. Islamoglu Y, Celik B, Kiris M. Facial paralysis as the only symptom of COVID‐19: A prospective study. Am J Otolaryngol. 2021;42:102956. https://doi.org/10.1016/j.amjoto.2021.102956
  19. Kilic O, Kalcioglu MT, Cag Y, et al. Could sudden sensorineural hear-ing loss be the sole manifestation of COVID‐19? An investigation into SARS‐COV‐2 in the etiology of sudden sensorineural hearing loss. Int J Infect Dis. 2020;97:208‐211.  https://doi.org/10.1016/j.ijid.2020.06.023
  20. Degen C, Lenarz T, Willenborg K. Acute profound sensorineuralhearing loss after COVID‐19 pneumonia. Mayo Clin Proc. 2020;95:1801‐1803. https://doi.org/10.1016/j.mayocp.2020.05.034
  21. Abdel Rhman S, Abdel Wahid A. COVID‐19 and sudden sensorineural hearing loss, a case report. Otolaryngology Case Reports. 2020;16:100198. https://doi.org/10.1016/j.xocr.2020.100198
  22. Munro KJ, Uus K, Almufarrij I, Chaudhuri N, Yioe V. Persistent self‐reported changes in hearing and tinnitus in post‐hospitalisationCOVID‐19 cases. Int J Audiol. 2020;59:889‐890.  https://doi.org/10.1080/14992027.2020.1798519
  23. Yachou Y, El Idrissi A, Belapasov V, AitBenali S. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurol Sci. 2020;41(10):2657-2669. https://doi.org/10.1007/s10072-020-04575-3
  24. Deca vel P, Petit C, Tatu L. Tapia syndrome at the time of the COVID-19 pandemic: Lower cranial neuropathy following prolonged intubation. Neurology. 2020;95(7):312-313.  https://doi.org/10.1212/WNL.0000000000010011
  25. Khacha A, Bouchal S, Ettabyaoui A, et al. Cavernous sinus thrombosis in a COVID-19 patient: A case report. Radiol Case Rep. 2021;16(3):480-482.  https://doi.org/10.1016/j.radcr.2020.12.013
  26. Katyal N, Narula N, Acharya S, Govindarajan R. Neuromuscular complications with SARS-Cov-2 infection: a review. Front Neurol. 2020;11:1052. https://doi.org/10.3389/fneur.2020.01052
  27. Dos Santos Martins TG. Isolated post SARS-CoV-2 diplopia. J Neurol. 2021;268(2):391.  https://doi.org/10.1007/s00415-020-10072-6
  28. Trentinaglia M, Lippi G, Salvagno GL. Peripheral neuropathies during the COVID-19 pandemic: is there a relation? Immunol Res. 2022;23(7):1-6.  https://doi.org/10.1007/s12026-022-09272-1
  29. Gutiérrez-Ortiz C, Méndez-Guerrero A, Rodrigo-Rey S, et al. Miller Fisher syndrome and polyneuritis cranialis in COVID-19. Neurology. 2020;95(5):601-605.  https://doi.org/10.1212/WNL.0000000000009619
  30. Dinkin M, Gao V, Kahan J, et al. COVID-19 presenting with ophthalmoparesis from cranial nerve palsy. Neurology. 2020;95(5):221-223.  https://doi.org/10.1212/WNL.0000000000009700
  31. Lantos JE, Strauss SB, Lin E. COVID-19-associated Miller Fisher syndrome: MRI findings. Am J Neuroradiol. 2020;41(7):1184-1186. https://doi.org/10.3174/ajnr.A6609
  32. Fernández-Domínguez J, AmeijideSanluis E, García-Cabo C, et al. Miller Fisher-like syndrome related to SARSCoV-2 infection (COVID-19). J Neurol. 2020;267(9):2495-2496. PMID: 32458195. https://doi.org/10.1007/s00415-020-09912-2
  33. Kamchatnov PR, Evzelman MA, Chugunov AV. Peripheral nervous system disorders in COVID-19. RMJ. 2021;5:30-34. (In Russ.).
  34. Oaklander AL, Mills AJ, Kelley M, et al. Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID. Neurology. Neuroimmunology & Neuroinflammation. March 1, 2022. https://doi.org/10.1212/NXI.0000000000001146
  35. Stein M, Bell MJ, Ang LC. Hydroxychloroquine neuromyotoxicity. J Rheumatol. 2000;27(12):2927-2931. PMID: 11128688.
  36. Restivo DA, Centonze D, Alesina A, Marchese-Ragona R. Myasthenia gravis associated with SARS-CoV-2 infection. Ann Intern Med. 2020;173(12):1027-1028. https://doi.org/10.7326/L20-0845
  37. Sriwastava S, Tandon M, Kataria S, et al. New onsetof ocular myasthenia gravis in a patient with COVID‐19: a novelcase report and literature review. J Neurol. 2020;268(8):2690-2696. https://doi.org/10.1007/s00415‐020‐10263‐1
  38. Huber M, Rogozinski S, Puppe W, et al. Postinfectious onset ofmyasthenia gravis in a COVID‐19 patient. Front Neurol. 2020;11:576153. https://doi.org/10.3389/fneur.2020.576153
  39. Muhammed L, Baheerathan A, Cao M, Leite MI, Viegas S. MuSKantibody‐associated myasthenia gravis with SARS‐CoV‐2 infection: a case report. Ann Intern Med. 2021;174(6):872‐873.  https://doi.org/10.7326/L20‐1298
  40. Assini A, Gandoglia I, Damato V, et al. Myasthenia gravis associated with anti‐MuSK antibodies developedafter SARS‐CoV‐2 infection. Eur J Neurol. 2021;28(10):3537‐3539. https://doi.org/10.1111/ene.14721
  41. Malik GR, Wolfe AR, Soriano R, et al. Injury‐prone: peripheral nerveinjuries associated with prone positioning for COVID‐19‐relatedacute respiratory distress syndrome. Br J Anaesth. 2020;125:478‐480.  https://doi.org/10.1016/j.bja.2020.08.045
  42. Zhou L, Siao P. Lateral femoral cutaneous neuropathy caused byprone positioning to treat COVID‐19‐associated acute respiratory distress syndrome. Muscle Nerve. 2021;63(6):50‐52.  https://doi.org/10.1002/mus.27202
  43. Ballve A, Llaurado A, Palasi A, et al. Weakness as a complication of COVID-19 in critically ill patients: clinical features and prognostic factors in a case series. Rev Neurol. 2021;73:10-16.  https://doi.org/10.33588/rn.7301.2021042
  44. Silva-Hernández L, Cabal-Paz B, Mayo-Canalejo D, Horga A. Post-COVID symptoms of potential peripheral nervous and muscular origin. Neurology Perspectives. November 2021. https://doi.org/10.1016/j.neurop.2021.11.002

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.