COVID-19 (Corona Virus Disease 2019) is an acute respiratory disease accompanied by extrapulmonary manifestations in addition to pulmonary complications. Hereditary diseases can lead to an atypical course of COVID-19. The article describes a rare case of developing aortic aneurysm following SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) re-infection in a patient with Noonan syndrome.

MATERIAL AND METHODS

A standard pathological autopsy technique was used with sections treated with hematoxylin and eosin.

CASE REPORT

A patient, 27 years old, developed an acute condition 2 weeks before hospitalization, with signs of acute inflammation, increased body temperature, and general malaise. Later, he developed precordialgia and was urgently admitted to the hospital for pain syndrome. The increasing symptoms of acute cardiac and respiratory failure resulted in death. An autopsy revealed the signs of dissecting aortic aneurysm with rupture. Histological examination discovered a detachment of the endothelial and elastic layers of the aorta from the adventitial layer of the aorta.

CONCLUSION

This clinical case demonstrates the changes in the lungs and aorta in a patient with Noonan syndrome that occurred following re-infection with SARS-CoV-2 complicated by the development of severe viral interstitial pneumonia, dissecting aneurysm, and aortic rupture.