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Melnikov M.V.
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University;
National Research Center Institute of Immunology of the Federal Medical Biological Agency
Sviridova A.A.
Federal Center of Brain research and Neurotechnologies of the Federal Medical Biological Agency of Russia
Rogovskii V.S.
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University
Boyko A.N.
Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency
Pashenkov M.V.
National Research Center Institute of Immunology of the Federal Medical Biological Agency of Russia
The role of macrophages in the development of neuroinflammation in multiple sclerosis
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5): 51‑56
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To cite this article:
Melnikov MV, Sviridova AA, Rogovskii VS, Boyko AN, Pashenkov MV. The role of macrophages in the development of neuroinflammation in multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry.
2022;122(5):51‑56. (In Russ.)
https://doi.org/10.17116/jnevro202212205151
Multiple sclerosis (MS) is a chronic demyelinating and neurodegenerative disease of the central nervous system with an autoimmune mechanism of development. It is known that along with T- and B-lymphocytes, cells of the innate immune system also play a significant role in the pathogenesis of MS. Macrophages are central to the functioning of the innate immune response and, depending on the phenotype, have pro-and anti-inflammatory properties. In the central nervous system, resident macrophages form microglia capable of presenting antigens and producing cytokines and, depending on phenotype, may participate in the development of autoimmune inflammation or maintaining immunological tolerance. The brief report presents data on the participation of macrophages in the pathogenesis of experimental autoimmune encephalomyelitis and MS. In addition, current methods of modulation of macrophage functions for the treatment of MS are discussed.
Authors:
Melnikov M.V.
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University;
National Research Center Institute of Immunology of the Federal Medical Biological Agency
Sviridova A.A.
Federal Center of Brain research and Neurotechnologies of the Federal Medical Biological Agency of Russia
Rogovskii V.S.
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University
Boyko A.N.
Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency
Pashenkov M.V.
National Research Center Institute of Immunology of the Federal Medical Biological Agency of Russia
Received:
10.11.2021
Accepted:
26.11.2021
List of references:
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