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Bazhanova E.D.

Sechenov Institute of Evolutionary Physiology and Biochemistry;
Golikov Scientific and Clinical Center of Toxicology;
Astrakhan State University

Kozlov A.A.

Sechenov Institute of Evolutionary Physiology and Biochemistry

Mechanisms of apoptosis in drug-resistant epilepsy

Authors:

Bazhanova E.D., Kozlov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5): 43‑50

DOI: 10.17116/jnevro202212205143

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MECHANISMS OF APOPTOSIS IN DRUG-RESISTANT EPILEPSY
MECHANISMS OF APOPTOSIS IN DRUG-RESISTANT EPILEPSY

To cite this article:

Bazhanova ED, Kozlov AA. Mechanisms of apoptosis in drug-resistant epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5):43‑50. (In Russ.)
https://doi.org/10.17116/jnevro202212205143

 
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Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced quality of life. Apoptosis of neurons and glial cells of the brain is of great importance in the pathogenesis of epilepsy, especially drug-resistant epilepsy. Investigation of the mechanisms of apoptosis is necessary for the creation of a new generation of neuroprotective and anticonvulsant drugs, effective, in particular, in the case of drug-resistant epilepsy. The aim of the study was to analyze the mechanisms and role of apoptosis in epileptogenesis and the development of resistance. The review considers current data on the main mechanisms of apoptosis in epilepsy, especially its drug-resistant forms.

Keywords:

drug-resistant epilepsy
pathogenesis
apoptosis

Authors:

Bazhanova E.D.

Sechenov Institute of Evolutionary Physiology and Biochemistry;
Golikov Scientific and Clinical Center of Toxicology;
Astrakhan State University

Kozlov A.A.

Sechenov Institute of Evolutionary Physiology and Biochemistry

Received:

08.07.2021

Accepted:

18.10.2021

List of references:

  1. Cardenas-Rodriguez N, Huerta-Gertrudis B, Rivera-Espinosa L, et al. Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models. Int J Mol Sci. 2013;14:1455-1476. https://doi.org/10.3390/ijms14011455
  2. Espinosa-Garcia C, Zeleke H, Rojas A. Impact of Stress on Epilepsy: Focus on Neuroinflammation — A Mini Review. Int J Mol Sci. 2021;22(8):4061. https://doi.org/10.3390/ijms22084061
  3. Henshall DC, Simon RP. Epilepsy and apoptosis pathways. J Cereb Blood Flow Metab. 2005;25(12):1557-1572. https://doi.org/10.1038/sj.jcbfm.9600149
  4. Beghi E, Giussani G, Sander JW. The natural history and prognosis of epilepsy. Epileptic Disord. 2015;17(3):243-253.  https://doi.org/10.1684/epd.2015.0751
  5. DeGiorgio CM, Curtis A, Carapetian A, et al. Why are epilepsy mortality rates rising in the United States? A population-based multiple cause-of-death study. BMJ Open. 2020;10(8):e035767. https://doi.org/10.1136/bmjopen-2019-035767
  6. Reddy SD, Younus I, Sridhar V, Reddy DS. Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy. Int J Mol Sci. 2019;20(1):220.  https://doi.org/10.3390/ijms20010220
  7. Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010;51(6):1069-1077. https://doi.org/10.1111/j.1528-1167.2009.02397.x
  8. Li T-R, Jia Y-J, Wang Q, et al. Correlation between tumor necrosis factor alpha mRNA and microRNA-155 expression in rat models and patients with temporal lobe epilepsy. Brain Res. 2018;1700:56-65.  https://doi.org/10.1016/j.brainres.2018.07.013
  9. Haarbauer-Krupa J, Pugh MJ, Prager EM, et al. Epidemiology of Chronic Effects of Traumatic Brain Injury. J Neurotrauma. 2021;34(6):34-39.  https://doi.org/10.1089/neu.2021.0062
  10. Pearson-Smith JN, Patel M. Metabolic Dysfunction and Oxidative Stress in Epilepsy. Int J Mol Sci. 2017;18(11):2365. https://doi.org/10.3390/ijms18112365
  11. Beghi E. The Epidemiology of Epilepsy. Neuroepidemiology. 2020;54(2):185-191.  https://doi.org/10.1159/000503831
  12. Ananias M, D’Souza-Li T, D’Souza-Li L. Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis. Mediators Inflamm. 2016;2016:8290562. https://doi.org/10.1155/2016/8290562
  13. Choi J, Choi SA, Kim S, et al. Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus. Annals of Child Neurology. 2019;27(2):38-45.  https://doi.org/10.26815/acn.2019.00038
  14. Hao Y, Bai S, Peng J, et al. TRIM27-mediated ubiquitination of PPARγ promotes glutamate-induced cell apoptosis and inflammation. Experimental Cell Research. 2021;400(1):112437. https://doi.org/10.1016/j.yexcr.2020.112437
  15. Strauss KI, Elisevich KV. Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy. J Neuroinflammation. 2016;13(1):270.  https://doi.org/10.1186/s12974-016-0727-z
  16. Gonzalez OC, Krishnan GP, Timofeev I, Bazhenov M. Ionic and synaptic mechanisms of seizure generation and epileptogenesis. Neurobiol Dis. 2019;130:104485. https://doi.org/10.1016/j.nbd.2019.104485
  17. Lin T-K, Chen S-D, Lin K-J, Chuang Y-C. Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial? Antioxidants (Basel). 2020;9(11):1029. https://doi.org/10.3390/antiox9111029
  18. Wuab H, Menga Q, Zhang Y, et al. Upregulated Nmnat2 causes neuronal death and increases seizure susceptibility in temporal lobe epilepsy. Brain Res Bull. 2021;167:1-10.  https://doi.org/10.1016/j.brainresbull.2020.11.019
  19. Wu Y, Chen M, Jiang J. Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion. 2019;49:35-45.  https://doi.org/10.1016/j.mito.2019.07.003
  20. Geronzi U, Lotti F, Grosso S. Oxidative stress in epilepsy. Expert Rev Neurother. 2018;18(5):427-434.  https://doi.org/10.1080/14737175.2018.1465410
  21. Kundap UP, Paudel YN, Shaikh MF. Animal Models of Metabolic Epilepsy and Epilepsy Associated Metabolic Dysfunction: A Systematic Review. Pharmaceuticals. 2020;13(6):106.  https://doi.org/10.3390/ph13060106
  22. Espinos C, Galindo MI, García-Gimeno MA, et al. Oxidative Stress, a Crossroad Between Rare Diseases and Neurodegeneration. Antioxidants. 2020;9(4):313.  https://doi.org/10.3390/antiox9040313
  23. Liu S, Jin Z, Zhang Y, et al. The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome. Front. Pharmacol. 2020;11:136.  https://doi.org/10.3389/fphar.2020.00136
  24. Chen C, Mei Q, Wang L, et al. TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis. Biochem Biophys Res Commun. 2019;515(3):436-441.  https://doi.org/10.1016/j.bbrc.2019.05.156
  25. Su Q, Zheng B, Wang C, et al. Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467. Cell Physiol Biochem. 2018;46(4):1536-1554. https://doi.org/10.1159/000489198
  26. Hashemi P, Babaei JF, Vazifekhah S, Nikbakht F. Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway. Iran J Basic Med Sci. 2019;22(7):752-758.  https://doi.org/10.22038/ijbms.2019.33892.8064
  27. Uytterhoeven V, Kaempf N, Verstreken P. Mitochondria re-set epilepsy. Neuron. 2019;102(5):907-910.  https://doi.org/10.1016/j.neuron.2019.05.023
  28. Chan F, Lax NZ, Voss CM, et al. The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction. Brain. 2019;142(2):391-411.  https://doi.org/10.1093/brain/awy320
  29. Zhang Y, Zhang M, Zhu W, et al. Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model. Redox Biol. 2020;28:101365. https://doi.org/10.1016/j.redox.2019.101365
  30. Gano LB, Liang L-P, Ryan K, et al. Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Free Radic Biol Med. 2018;123:116-124.  https://doi.org/10.1016/j.freeradbiomed.2018.05.063
  31. Finsterer J, Scorza FA. Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival. Epilepsy Res. 2017;136:5-11.  https://doi.org/10.1016/j.eplepsyres.2017.07.003
  32. Saneto RP. Epilepsy and mitochondrial dysfunction: a single Center’s experience. J inborn errors metab. screen. 2017;5:2326409817733012. https://doi.org/10.1177/2326409817733012
  33. Vasquez A, Farias-Moeller R, Tatum W. Pediatric refractory and super-refractory status epilepticus. Seizure. 2019;68:62-71.  https://doi.org/10.1016/j.seizure.2018.05.012
  34. Nigoghossian CD, Rubinos C, Alkhachroum A, Claassen J. Status epilepticus — time is brain and treatment considerations. Curr Opin Crit Care. 2019;25(6):638-646.  https://doi.org/10.1097/MCC.0000000000000661
  35. Culmsee C, Mattson MP. p53 in neuronal apoptosis. Biochem Biophys Res Commun. 2005;331(3):761-777.  https://doi.org/10.1016/j.bbrc.2005.03.149
  36. Pearson-Smith JN, Liang L-P, Rowley SD, et al. Oxidative Stress Contributes to Status Epilepticus Associated Mortality. Neurochem Res. 2017;42(7):2024-2032. https://doi.org/10.1007/s11064-017-2273-1
  37. Fricker M, Tolkovsky AM, Borutaite V, et al. Neuronal Cell Death. Physiol Rev. 2018;98(2):813-880.  https://doi.org/10.1152/physrev.00011.2017
  38. Huang Q, Liu X, Wu Y, et al. P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. Epilepsy Res. 2017;133:89-92.  https://doi.org/10.1016/j.eplepsyres.2017.04.012
  39. Henshall DC. Apoptosis signalling pathways in seizure-induced neuronal death and epilepsy. Biochem Soc Trans. 2007;35(Pt 2):421-423.  https://doi.org/10.1042/BST0350421
  40. Li Q, Li Q-Q, Jia J-N, et al. Sodium Valproate Ameliorates Neuronal Apoptosis in a Kainic Acid Model of Epilepsy via Enhancing PKC-Dependent GABAAR γ2 Serine 327 Phosphorylation. Neurochem Res. 2018;43(12):2343-2352. https://doi.org/10.1007/s11064-018-2659-8
  41. Sazhina TA, Sitovskaya DA, Zabrodskaya YuM, Bazhanova ED. Functional Imbalance of Glutamate- and GABAergic Neuronal Systems in the Pathogenesis of Focal Drug-Resistant Epilepsy in Humans. Bulletin of Experimental Biology and Medicine. 2020;168:529-532.  https://doi.org/10.1007/s10517-020-04747-3
  42. Bengzon J, Mohapel P, Ekdahl CT, Lindvall O. Neuronal apoptosis after brief and prolonged seizures. Prog Brain Res. 2002;135:111-119.  https://doi.org/10.1016/S0079-6123(02)35011-8
  43. Wang W, Ma Y-M, Jiang Z-L, et al. Apoptosis-antagonizing transcription factor is involved in rat post-traumatic epilepsy pathogenesis. Exp Ther Med. 2021;21(4):290.  https://doi.org/10.3892/etm.2021.9721
  44. Glushakova OY, Glushakov AO, Borlongan CV, Valadka AB, Hayes RL, Glushakov AV. Role of caspase-3-mediated apoptosis in chronic caspase-3-cleaved tau accumulation and blood-brain barrier damage in the corpus callosum after traumatic brain injury in rats. J Neurotrauma. 2018;35(1):157-173.  https://doi.org/10.1089/neu.2017.4999
  45. Mao X-Y, Zhou H-H, Jin W-L. Redox-Related Neuronal Death and Crosstalk as Drug Targets: Focus on Epilepsy. Front Neurosci. 2019;13:512.  https://doi.org/10.3389/fnins.2019.00512
  46. Zhao H, Zhu C, Huang D. Microglial activation: an important process in the onset of epilepsy. Am J Transl Res. 2018;10(9):2877-2889. PMID: 30323874.
  47. Lin RT, Cai RR, Zhang PF, Lin YX. Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy. Zhonghua Yi Xue Za Zhi. 2016;96(7):522-525.  https://doi.org/10.3760/cma.j.issn.0376-2491.2016.07.006
  48. Jiang J, Feng J, Wu L, et al. Triptolide Inhibits Neuronal Apoptosis in a Rat Model of Pentylenetetrazol-Induced-Epilepsy via Upregulation of miR-187 Expression. Current Topics in Nutraceutical Research. 2020;18(3):284-291.  https://doi.org/10.37290/ctnr2641-452X.18:284-291
  49. Sun Z-Q, Meng F-H, Tu L-X, Sun L. Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF-TrkB signaling pathway and modulating matrix metalloproteinase-9 and GABA A. Exp Ther Med. 2019;17(4):3083-3091. https://doi.org/10.3892/etm.2019.7282
  50. Liu J-T, Wu S-X, Zhang H, Kuang F. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics. 2018;15(4):1093-1111. https://doi.org/10.1007/s13311-018-0653-0
  51. Hiragi T, Ikegaya Y, Koyama R. Microglia after Seizures and in Epilepsy. Cell. 2018;7(4):26.  https://doi.org/10.3390/cells7040026
  52. Attia GM, Elmansy RA, Elsaed WM. Neuroprotective effect of nilotinib on pentylenetetrazol-induced epilepsy in adult rat hippocampus: involvement of oxidative stress, autophagy, inflammation, and apoptosis. Folia Neuropathol. 2019;57(2):146-160.  https://doi.org/10.5114/fn.2019.84423
  53. El‐Hodhod MA, Tomoum HY, Abd Al‐Aziz MM, Samaan SM. Serum Fas and Bcl‐2 in patients with epilepsy. Acta Neurologica Scandinavica. 2006;113(5):315-321.  https://doi.org/10.1111/j.1600-0404.2006.00592.x
  54. Feng J, Feng L, Zhang G. Mitochondrial damage in hippocampal neurons of rats with epileptic protein expression of Fas and caspase-3. Exp Ther Med. 2018;16(3):2483-2489. https://doi.org/10.3892/etm.2018.6439
  55. Rubio C, Mendoza C, Trejo C, et al. Activation of the Extrinsic and Intrinsic Apoptotic Pathways in Cerebellum of Kindled Rats. Cerebellum. 2019;18(4):750-760.  https://doi.org/10.1007/s12311-019-01030-8
  56. Li Q, Han Y, Du J, et al. Alterations of apoptosis and autophagy in developing brain of rats with epilepsy: Changes in LC3, P62, Beclin-1 and Bcl-2 levels. Neurosci Res. 2018;130:47-55.  https://doi.org/10.1016/j.neures.2017.08.004
  57. Skardoutsou A, Primikiris P, Tsentidis C, et al. Bcl-2 and Caspase-9 serum levels in children and adolescents with idiopathic epilepsy and active seizures. Minerva Pediatr. 2017;23(2):34-39.  https://doi.org/10.23736/S0026-4946.17.04787-9
  58. Toscano ECB, Vieira ELM, Portela ACDC, et al. Bcl-2/Bax ratio increase does not prevent apoptosis of glia and granular neurons in patients with temporal lobe epilepsy. Neuropathology. 2019;39(5):348-357.  https://doi.org/10.1111/neup.12592
  59. Wang L, Wang Y, Duan C, Yang Q. Inositol phosphatase INPP4A inhibits the apoptosis of in vitro neurons with characteristic of intractable epilepsy by reducing intracellular Ca2+ concentration. Int J Clin Exp Pathol. 2018;11(4):1999-2007. PMID: 31938306.
  60. Mendez-Armenta M, Nava-Ruiz C, Juarez-Rebollar D, et al. Oxidative Stress Associated with Neuronal Apoptosis in Experimental Models of Epilepsy. Oxid Med Cell Longev. 2014;2014:293689. https://doi.org/10.1155/2014/293689
  61. Jung S, Ballheimer YE, Brackmann F, et al. Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain. Brain Res. 2020;1735:146760. https://doi.org/10.1016/j.brainres.2020.146760
  62. Toscano ECB, Vieira ELM, Portela ACDC, et al. Bcl‐2/Bax ratio increase does not prevent apoptosis of glia and granular neurons in patients with temporal lobe epilepsy. Neuropathology. 2019;39(5):348-357.  https://doi.org/10.1111/neup.12592
  63. Zhao Y, Jiang W-J, Ma L, et al. Voltage-dependent anion channels mediated apoptosis in refractory epilepsy. Open Med (Wars). 2020;15(1):745-753.  https://doi.org/10.1515/med-2020-0113
  64. Jiang W, Du B, Chi Z, et al. Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative proteomics. J Neurosci Res. 2007;85(14):3160-3170. https://doi.org/10.1002/jnr.21384
  65. Kegler A, Caprara ALF, Pascotini ET, et al. Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways. Biomed Res Int. 2020;2020:6250429. https://doi.org/10.1155/2020/6250429
  66. Leal B, Chaves J, Carvalho C, et al. Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients. Journal of Neuroimmunology. 2017;313:82-88.  https://doi.org/10.1016/j.jneuroim.2017.10.014
  67. Vega-Garcia A, Orozco-Suarez S, Villa A, et al. Cortical expression of IL1-β, Bcl-2, Caspase-3 and 9, SEMA-3a, NT-3 and P-glycoprotein as biological markers of intrinsic severity in drug-resistant temporal lobe epilepsy. Brain Res. 2021;1758:147303. https://doi.org/10.1016/j.brainres.2021.147303
  68. Dutra MRH, Feliciano RS, Jacinto KR, et al. Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine. Oxid Med Cell Longev. 2018;6736721. https://doi.org/10.1155/2018/6736721
  69. Arulsamy A, Shaikh MF. Tumor Necrosis Factor-α, the Pathological Key to Post-Traumatic Epilepsy: A Comprehensive Systematic Review. ACS Chem. Neurosci. 2020;11:13:1900-1908. https://doi.org/10.1021/acschemneuro.0c00301
  70. Sharma R, Leung WL, Zamani A, et al. Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets. Brain Sci. 2019;9(11):318.  https://doi.org/10.3390/brainsci9110318
  71. Wu D, Zheng Z, Fan S, et al. Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells. Experimental and Therapeutic Medicine. 2020;20(2):854-859.  https://doi.org/10.3892/etm.2020.8742
  72. Patel DC, Wallis G, Dahle EJ, et al. Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy. eNeuro. 2017;9;4(2):ENEURO.0105-17.2017. https://doi.org/10.1523/ENEURO.0105-17.2017
  73. Burla R, La Torre M, Zanetti G, et al. p53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice. Front Genet. 2018;9:581.  https://doi.org/10.3389/fgene.2018.00581
  74. Liu D, Li S, Gong L, et al. Suppression of microRNA‐141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. Journal of cellular Biochemistry. 2019;120(6):9409-9420. https://doi.org/10.1002/jcb.28216
  75. Liu D-C, Eagleman DE, Tsai N-P. Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation. PLoS Genet. 2019;15(9):e1008364. https://doi.org/10.1371/journal.pgen.1008364
  76. Liu A-H, Chu M, Wang Y-P. Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice. Neuroscience Bulletin. 2019;35(3):471-485.  https://doi.org/10.1007/s12264-018-0324-5
  77. Wu Q, Yi X. Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy. Journal of Molecular Neuroscience. 2018;65(2):234-245.  https://doi.org/10.1007/s12031-018-1093-3
  78. Hu F, Shao L, Zhang J, et al. Knockdown of ZFAS1 Inhibits Hippocampal Neurons Apoptosis and Autophagy by Activating the PI3K/AKT Pathway via Up-regulating miR-421 in Epilepsy. Neurochemical Research. 2020;45(10):2433-2441. https://doi.org/10.1007/s11064-020-03103-1
  79. Bhowmick S, D’Mello V, Abdul-Muneer P.M. Synergistic Inhibition of ERK1/2 and JNK, Not p38, Phosphorylation Ameliorates Neuronal Damages After Traumatic Brain Injury. Mol Neurobiol. 2019;56(2):1124-1136. https://doi.org/10.1007/s12035-018-1132-7
  80. Chernigovskaya EV, Korotkov AA, Dorofeeva NA, Gorbacheva EL, Kulikov AA, Glazova MV. Delayed audiogenic seizure development in a genetic rat model is associated with overactivation of ERK1/2 and disturbances in glutamatergic signaling. Epilepsy Behav. 2019;99:106494. https://doi.org/10.1016/j.yebeh.2019.106494
  81. Dorofeeva NA, Grigorieva YS, Nikitina LS, Lavrova EA, Nasluzova EV, Glazova MV, Chernigovskaya EV. Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures. Neurol Res. 2017;39(10):918-925.  https://doi.org/10.1080/01616412.2017.1356156

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