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Bazhanova E.D.

Sechenov Institute of Evolutionary Physiology and Biochemistry;
Golikov Scientific and Clinical Center of Toxicology;
Astrakhan State University

Kozlov A.A.

Sechenov Institute of Evolutionary Physiology and Biochemistry

Mechanisms of apoptosis in drug-resistant epilepsy

Authors:

Bazhanova E.D., Kozlov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5): 43‑50

DOI: 10.17116/jnevro202212205143

Read: 3217 times

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Table of contents

MECHANISMS OF APOPTOSIS IN DRUG-RESISTANT EPILEPSY
MECHANISMS OF APOPTOSIS IN DRUG-RESISTANT EPILEPSY

To cite this article:

Bazhanova ED, Kozlov AA. Mechanisms of apoptosis in drug-resistant epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5):43‑50. (In Russ.)
https://doi.org/10.17116/jnevro202212205143

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Использование инфографики авторами научных работ
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Abstract:

Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced quality of life. Apoptosis of neurons and glial cells of the brain is of great importance in the pathogenesis of epilepsy, especially drug-resistant epilepsy. Investigation of the mechanisms of apoptosis is necessary for the creation of a new generation of neuroprotective and anticonvulsant drugs, effective, in particular, in the case of drug-resistant epilepsy. The aim of the study was to analyze the mechanisms and role of apoptosis in epileptogenesis and the development of resistance. The review considers current data on the main mechanisms of apoptosis in epilepsy, especially its drug-resistant forms.

Keywords:

drug-resistant epilepsy
pathogenesis
apoptosis

Authors:

Bazhanova E.D.

Sechenov Institute of Evolutionary Physiology and Biochemistry;
Golikov Scientific and Clinical Center of Toxicology;
Astrakhan State University

Kozlov A.A.

Sechenov Institute of Evolutionary Physiology and Biochemistry

Received:

08.07.2021

Accepted:

18.10.2021

Close metadata

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