The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Bazhanova E.D.
Sechenov Institute of Evolutionary Physiology and Biochemistry;
Golikov Scientific and Clinical Center of Toxicology;
Astrakhan State University
Kozlov A.A.
Sechenov Institute of Evolutionary Physiology and Biochemistry
Mechanisms of apoptosis in drug-resistant epilepsy
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5): 43‑50
Views: 2359
Downloaded: 61
To cite this article:
Bazhanova ED, Kozlov AA. Mechanisms of apoptosis in drug-resistant epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry.
2022;122(5):43‑50. (In Russ.)
https://doi.org/10.17116/jnevro202212205143
Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced quality of life. Apoptosis of neurons and glial cells of the brain is of great importance in the pathogenesis of epilepsy, especially drug-resistant epilepsy. Investigation of the mechanisms of apoptosis is necessary for the creation of a new generation of neuroprotective and anticonvulsant drugs, effective, in particular, in the case of drug-resistant epilepsy. The aim of the study was to analyze the mechanisms and role of apoptosis in epileptogenesis and the development of resistance. The review considers current data on the main mechanisms of apoptosis in epilepsy, especially its drug-resistant forms.
Keywords:
Authors:
Bazhanova E.D.
Sechenov Institute of Evolutionary Physiology and Biochemistry;
Golikov Scientific and Clinical Center of Toxicology;
Astrakhan State University
Kozlov A.A.
Sechenov Institute of Evolutionary Physiology and Biochemistry
Received:
08.07.2021
Accepted:
18.10.2021
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.