The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Zuev A.A.

Pirogov Russian National Research Medical University

Pedyash N.V.

Pirogov National Medical Surgical Center

Utyashev N.P.

Pirogov National Medical Surgical Center

Ivin N.O.

Pirogov National Medical Surgical Center

Utyasheva A.A.

Pirogov National Medical Surgical Center

Gordeeva E.A.

Pirogov National Medical Surgical Center

Surgical treatment of drug-resistant epilepsy

Authors:

Zuev A.A., Pedyash N.V., Utyashev N.P., Ivin N.O., Utyasheva A.A., Gordeeva E.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2025;89(5): 28‑36

Read: 261 times


To cite this article:

Zuev AA, Pedyash NV, Utyashev NP, Ivin NO, Utyasheva AA, Gordeeva EA. Surgical treatment of drug-resistant epilepsy. Burdenko's Journal of Neurosurgery. 2025;89(5):28‑36. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20258905128

Recommended articles:
Giant peri­cranial sinus with exte­nsive occi­pital calvarium defect. Burdenko's Journal of Neurosurgery. 2024;(6):77-87
The Russian consensus on the treatment of intrahepatic cholangiocarcinoma. Piro­gov Russian Journal of Surgery. 2024;(10):7-20
Diagnostic scales for acute appe­ndicitis in children. Piro­gov Russian Journal of Surgery. 2024;(10):80-87
Foreign body of the thyroid gland. Piro­gov Russian Journal of Surgery. 2024;(10):102-108
Heavy eye syndrome: clinical mani­festations, diagnosis and treatment. Russian Annals of Ophthalmology. 2024;(5):112-117

References:

  1. Mesraoua B, Brigo F, Lattanzi S, Abou-Khalil B, Al Hail H, Asadi-Pooya AA. Drug-resistant epilepsy: Definition, pathophysiology, and management. Journal of the Neurological Sciences. 2023;452:120766. https://doi.org/10.1016/j.jns.2023.120766
  2. Chen Z, Brodie MJ, Liew D, Kwan P. Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study. JAMA Neurology. 2018;75(3):279-286.  https://doi.org/10.1001/jamaneurol.2017.3949
  3. Xu X, Sha L, Basang S, Peng A, Zhou X, Liu Y, Li Y, Chen L. Mortality in patients with epilepsy: a systematic review. Journal of Neurology. 2025;272(4):291.  https://doi.org/10.1007/s00415-025-13002-6
  4. Ngan Kee N, Foster E, Marquina C, Tan A, Pang SST, O’Brien TJ, Kwan P, Jackson GD, Chen Z, Ademi Z. Systematic Review of Cost-Effectiveness Analysis for Surgical and Neurostimulation Treatments for Drug-Resistant Epilepsy in Adults. Neurology. 2023;100(18):e1866-e1877. https://doi.org/10.1212/WNL.0000000000207137
  5. Dong H, Shi J, Wei P, Shan Y, Zhao G. Comparative Efficacy of Surgical Strategies for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis. World Neurosurgery. 2025;195:123729. https://doi.org/10.1016/j.wneu.2025.123729
  6. Krylov VV, Guekht AB, Trifonov IS, Lebedeva AV, Rider FK, Kaimovsky IL, Sinkin MV, Kordonskaya OO, Magomedsultanov AI, Navruzov RA, Yakovlev AA, Grigorieva EV, Mamulashvili GV. Long-term postoperative outcomes in patients with drug-resistant epilepsy. Burdenko’s Journal of Neurosurgery. 2021;85(5):6-13. (In Russ., In Engl.) https://doi.org/10.17116/neiro2021850516
  7. Zuev AA, Golovteev AL, Pedyash NV, Kalybaeva NA, Bronov OYu. Pre-surgical Diagnosties in Patients with Intractable epilepsy. Burdenko’s Journal of Neurosurgery. 2020;84(1):109-117. (In Russ., In Engl.). https://doi.org/10.17116/neiro202084011109
  8. Skidmore CT. Neuroimaging in Epilepsy. Continuum. 2025;31(1):61-80.  https://doi.org/10.1212/CON.0000000000001527
  9. Krylov VV, Guekht AB, Trifonov IS, Magomedsultanov AI, Navruzov RA, Lebedeva AV, Rider FK, Kaimovsky IL, Sinkin MV, Kordonskaia OO, Grigorieva EV, Nehoroshih AE, Yakovlev AA. Early and long-term outcomes of surgical treatment of patients with drug-resistant epilepsy. Russian Neurological Journal. 2022;27(1):52-61. (In Russ.). https://doi.org/10.30629/2658-7947-2022-27-1-52-61
  10. Hagemann A, Bien CG, Kalbhenn T, Hopf JL, Grewe P. Epilepsy Surgery in Extratemporal vs Temporal Lobe Epilepsy: Changes in Surgical Volumes and Seizure Outcome Between 1990 and 2017. Neurology. 2022;98(19):e1902-e1912. https://doi.org/10.1212/WNL.0000000000200194
  11. Sanders MW, Van der Wolf I, Jansen FE, Aronica E, Helmstaedter C, Racz A, Surges R, Grote A, Becker AJ, Rheims S, Catenoix H, Duncan JS, De Tisi J, Jacques TS, Cross JH, Kalviainen R, Rauramaa T, Chassoux F, Devaux BC, Di Gennaro G, Esposito V, Bodi I, Honavar M, Bien CG, Cloppenborg T, Coras R, Hamer HM, Marusic P, Kalina A, Pieper T, Kudernatsch M, Hartlieb TS, Von Oertzen TJ, Aichholzer M, Dorfmuller G, Chipaux M, Noachtar S, Kaufmann E, Schulze-Bonhage A, Scheiwe CF, Özkara C, Grunwald T, Koenig K, Guerrini R, Barba C, Buccoliero AM, Giordano F, Rosenow F, Menzler K, Garbelli R, Deleo F, Krsek P, Straka B, Arzimanoglou AA, Toulouse J, Van Paesschen W, Theys T, Pimentel J, Loução De Amorim IM, Specchio N, De Palma L, Feucht M, Scholl T, Roessler K, Toledano Delgado R, Gil-Nagel A, Raicevic S, Ristic AJ, Schijns O, Beckervordersandforth J, San Antonio-Arce V, Rumia J, Blumcke I, Braun KP; as the European Epilepsy Brain Bank Consortium (EEBB). Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue. Neurology. 2024;102(4):e208007. https://doi.org/10.1212/WNL.0000000000208007
  12. Pereira Dalio MTR, Velasco TR, Feitosa IDF, Assirati Junior JA, Carlotti Junior CG, Leite JP, Dos Santos AC, Alexandre V, Nakano FN, Saute RL, Wichert-Ana L, Sakamoto AC. Long-Term Outcome of Temporal Lobe Epilepsy Surgery in 621 Patients With Hippocampal Sclerosis: Clinical and Surgical Prognostic Factors. Frontiers in Neurology. 2022;13:833293. https://doi.org/10.3389/fneur.2022.833293
  13. Engel J Jr, Van Ness PC, Rasmussen TB, Ojemann LM. Outcome with respect to epileptic seizures. In: Engel J Jr, ed. Surgical treatment of the epilepsies. 2nd edn. New York: Raven Press; 1993.
  14. Jehi L, Jette N, Kwon CS, Josephson CB, Burneo JG, Cendes F, Sperling MR, Baxendale S, Busch RM, Triki CC, Cross JH, Ekstein D, Englot DJ, Luan G, Palmini A, Rios L, Wang X, Roessler K, Rydenhag B, Ramantani G, Schuele S, Wilmshurst JM, Wilson S, Wiebe S. Timing of referral to evaluate for epilepsy surgery: Expert Consensus Recommendations from the Surgical Therapies Commission of the International League Against Epilepsy. Epilepsia. 2022;63(10):2491-2506. https://doi.org/10.1111/epi.17350
  15. Steinbrenner M, Tito T, Dehnicke C, Holtkamp M. Predictors and reasons for epilepsy patients to decline surgery: a prospective study. Journal of Neurology. 2023;270(4):2302-2307. https://doi.org/10.1007/s00415-022-11510-3
  16. West S, Nevitt SJ, Cotton J, Gandhi S, Weston J, Sudan A, Ramirez R, Newton R. Surgery for epilepsy. Cochrane Database of Systematic Reviews. 2019;6(6):CD010541. https://doi.org/10.1002/14651858.CD010541.pub3
  17. Barot N, Batra K, Zhang J, Klem ML, Castellano J, Gonzalez-Martinez J, Bagic A. Surgical outcomes between temporal, extratemporal epilepsies and hypothalamic hamartoma: systematic review and meta-analysis of MRI-guided laser interstitial thermal therapy for drug-resistant epilepsy. Journal of Neurology, Neurosurgery and Psychiatry. 2022;93(2):133-143.  https://doi.org/10.1136/jnnp-2021-326185

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.