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Shirshkova V.I.

Sibirian State Medical University

Khardikova S.A.

Siberian State Medical University of the Ministry of Health of Russia

Protasevich A.A.

Sibirian State Medical University

Zhuravleva A.D.

Sibirian State Medical University

Study of the role of interleukin-1β in blood serum in patients with acne

Authors:

Shirshkova V.I., Khardikova S.A., Protasevich A.A., Zhuravleva A.D.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2025;24(4): 421‑424

DOI: 10.17116/klinderma202524041421

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Table of contents

STUDY OF THE ROLE OF INTERLEUKIN-1Β IN BLOOD SERUM IN PATIENTS WITH ACNE
STUDY OF THE ROLE OF INTERLEUKIN-1Β IN BLOOD SERUM IN PATIENTS WITH ACNE

To cite this article:

Shirshkova VI, Khardikova SA, Protasevich AA, Zhuravleva AD. Study of the role of interleukin-1β in blood serum in patients with acne. Russian Journal of Clinical Dermatology and Venereology. 2025;24(4):421‑424. (In Russ.)
https://doi.org/10.17116/klinderma202524041421

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The topic of acne is not losing its relevance despite numerous studies performed in this field. Not only adolescents but also adults visit a dermatologist with this skin disease. Study of acne pathogenesis is of professional interest in order to develop new algorithms for diagnosis and treatment of dermatosis.

OBJECTIVE

To determine the level of interleukin-1β in the blood of patients with acne diagnosis and with acne occurring in presence of opisthorchiasis, and compare these indicators with those in the control group, as well as to identify the relationship between IL-1β and skin process severity in acne.

MATERIAL AND METHODS

The study included 235 female and male patients. Among them, 135 patients were diagnosed with acne with varying severity, other 100 patients were healthy donors without acne for comparison of IL-1β indicators.

RESULTS

Patients with acne and with acne in presence of chronic opisthorchiasis had IL-1β level of 2.50 (1.90; 3.20) pg/ml, which is significantly higher (p<0.001) than healthy donors — 0.30 (0.15; 0.18) pg/ml. A positive correlation between the severity of acne and the level of IL-1β has been also determined. The more severe the skin process in acne is, the higher the IL-1β level is (p<0.001).

CONCLUSION

The obtained data on high IL-1β content in the blood serum in patients with acne and with acne in presence of chronic opisthorchiasis compared to healthy donors indicate maintenance of immune and inflammatory activity in the tissues of pilosebaceous follicle in patients with chronic dermatosis.

Keywords:

acne
pathogenesis
cytokines
genetic factors
interleukin

Authors:

Shirshkova V.I.

Sibirian State Medical University

Khardikova S.A.

Siberian State Medical University of the Ministry of Health of Russia

Protasevich A.A.

Sibirian State Medical University

Zhuravleva A.D.

Sibirian State Medical University

Received:

07.10.2024

Accepted:

22.05.2025

Close metadata

References:

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