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Levin O.S.

Russian Medical Academy of Continuous Professional Education

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Lobzin V.Yu.

General mechanisms of the pathogenesis of neurodenerative and cerebrovascular diseases and the possibilities of their correction

Authors:

Levin O.S., Bogolepova A.N., Lobzin V.Yu.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5): 11‑16

DOI: 10.17116/jnevro202212205111

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Table of contents

GENERAL MECHANISMS OF THE PATHOGENESIS OF NEURODENERATIVE AND CEREBROVASCULAR DISEASES AND THE POSSIBILITIES OF THEIR CORRECTION
GENERAL MECHANISMS OF THE PATHOGENESIS OF NEURODENERATIVE AND CEREBROVASCULAR DISEASES AND THE POSSIBILITIES OF THEIR CORRECTION

To cite this article:

Levin OS, Bogolepova AN, Lobzin VYu. General mechanisms of the pathogenesis of neurodenerative and cerebrovascular diseases and the possibilities of their correction. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5):11‑16. (In Russ.)
https://doi.org/10.17116/jnevro202212205111

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The recent research has revealed several common pathogenetic mechanisms underlying both vascular and neurodegenerative processes. This refers to chronic cerebral hypoperfusion, pathology of neurovascular units and the blood-brain barrier. The process of brain recovery in various lesions is realized due to the mechanisms of neuroplasticity. Using the example of Cerebrolysin, which has a multimodal effect, which includes an effect on the blood-brain barrier, a neurotrophic effect, an improvement in the drainage function of the brain, an anti-inflammatory effect, a direct effect on neurovascular units, the advantage of simultaneous action on various links of pathogenesis can be shown.

Keywords:

neurodegeneration
cerebrovascular pathology
hypoperfusion
blood-brain barrier
neurovascular unit
neuroplasticity
Cerebrolysin

Authors:

Levin O.S.

Russian Medical Academy of Continuous Professional Education

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Lobzin V.Yu.

Received:

31.03.2022

Accepted:

25.04.2022

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