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Malakhova A.I.

Smolensk Regional Clinical Hospital

Strakhov V.V.

Yaroslavl State Medical University

Malakhova Yu.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Objective structural and functional monitoring of polypeptide retinal neuroprotective therapy in diabetic retinopathy

Authors:

Malakhova A.I., Strakhov V.V., Malakhova Yu.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(5): 97‑104

DOI: 10.17116/oftalma202414005197

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Table of contents

OBJECTIVE STRUCTURAL AND FUNCTIONAL MONITORING OF POLYPEPTIDE RETINAL NEUROPROTECTIVE THERAPY IN DIABETIC RETINOPATHY
OBJECTIVE STRUCTURAL AND FUNCTIONAL MONITORING OF POLYPEPTIDE RETINAL NEUROPROTECTIVE THERAPY IN DIABETIC RETINOPATHY

To cite this article:

Malakhova AI, Strakhov VV, Malakhova YuA. Objective structural and functional monitoring of polypeptide retinal neuroprotective therapy in diabetic retinopathy. Russian Annals of Ophthalmology. 2024;140(5):97‑104. (In Russ.)
https://doi.org/10.17116/oftalma202414005197

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

In recent years, there has been a growing interest in the contribution of neuroretinal degeneration to the pathogenesis of diabetic retinopathy (DR), preceding the classic vascular changes associated with DR.

PURPOSE

This study evaluated the impact of the polypeptide drug Retinalamin on the structural and functional condition of the retina in patients with DR using optical coherence tomography (OCT) (Topcon OCT 2000 FA, Japan) and the Diopsys Nova vision testing system for electrophysiological studies of the visual organ.

MATERIAL AND METHODS

The clinical study included 56 patients (112 eyes) with type 1 and type 2 diabetes and DR without macular edema. Of these, 28 patients (56 eyes) comprised the main group receiving intramuscular Retinalamin. The control group consisted of 28 patients (56 eyes) who did not receive Retinalamin treatment. The thickness of the ganglion cell complex was analyzed by OCT imaging performed on the Topcon OCT 2000 FA. Electrophysiological studies of the visual organ were conducted using the Diopsys Nova vision testing system, following the Diopsys PERG24 (pattern ERG) and Diopsys ffERG/Multi-Luminance Flicker (full-field ERG, or flash ERG) protocols.

RESULTS

The study demonstrated convincing objective evidence of positive changes in the main observation group.

CONCLUSION

The emergence of two pathogenetically oriented neurodegenerative vectors of DR, involving both the inner and outer retina, significantly expands our understanding of this diabetic complication. This includes the potential for retinal neuroprotective treatment with peptide bioregulators in clinical practice, especially in the early stages of DR.

Keywords:

diabetic retinopathy
neurodegeneration
Retinalamin
electrophysiological studies
optical coherence tomography
Diopsys

Authors:

Malakhova A.I.

Smolensk Regional Clinical Hospital

Strakhov V.V.

Yaroslavl State Medical University

Malakhova Yu.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

20.08.2024

Accepted:

11.09.2024

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