Controlled arterial hypertension and blood-brain barrier damage in patients with age-related cerebral small vessel disease and cognitive impairments

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OBJECTIVE

To evaluate the relationship between blood pressure (BP) profile and blood-brain barrier (BBB) permeability in age-related cerebral microangiopathy (CMA) in patients with- and without controlled arterial hypertension (AH).

MATERIAL AND METHODS

24-hour ambulatory BP monitoring (ABPM), brain MRI, including T1-weighted dynamic contrast images, were performed in 53 patients with CMA (age 60.1±6.8, women 69.8%, controlled hypertension/normal BP 84.8%/15.2%) and 17 healthy volunteers.

RESULTS

ABPM showed good control of AH with most of the assessed parameters associated with the severity of white matter hyperintensity (WMH). The permeability of the BBB in normal-appearing white matter (NAWM) and gray matter in patients with CMA was significantly higher than in the control group and was associated with ABPM parameters. The permeability of the BBB in WMH decreased with an increase in its severity.

CONCLUSION

BBB permeability is a universal mechanism of NAWM and gray matter damage that supports the progression of WMH in CMA patients with controlled AH and without AH. The relationship of increased BBB permeability with slight deviations of ABPM can be explained by common mechanisms of their development due to endothelial dysfunction due to CMA and also points to the utility of more aggressive AH treatment. It is advisable to study the effect of antihypertensive and vascular drugs on BBB permeability with a view to their potential use in CMA.

Keywords:

cerebral small vessel disease

cognitive impairments

arterial hypertension

T1-weighted dynamic contrast-enhanced MRI

blood-brain barrier permeability

Authors:

Dobrynina L.A.

Research Center of Neurology

ORCID: 0000-0001-9929-2725

Shamtieva K.V.

Research Center of Neurology

Kremneva E.I.

Research Center of Neurology

Zabitova M.R.

Research Center of Neurology

Gadzhieva Z.Sh.

Research Center of Neurology

Krotenkova M.V.

Research Center of Neurology

Received:

02.09.2022

Accepted:

11.09.2022

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