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Smirnova M.D.

Chazov National Medical Research Center of Cardiology

Svirida O.N.

Chazov National Medical Research Center of Cardiology

Blankova Z.N.

Chazov National Medical Research Center of Cardiology

Vitsenya M.V.

Chazov National Medical Research Center of Cardiology

Ivanova A.Yu.

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

Ageev F.T.

Chazov National Medical Research Center of Cardiology

Medvedev O.S.

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

Influence of enzymatic activity of microbiota on hemodynamics, arterial stiffness and emotional state of patients with mild-to-moderate risk of cardiovascular complications

Authors:

Smirnova M.D., Svirida O.N., Blankova Z.N., Vitsenya M.V., Ivanova A.Yu., Ageev F.T., Medvedev O.S.

More about the authors

Journal: Russian Cardiology Bulletin. 2024;19(4‑2): 128‑136

DOI: 10.17116/Cardiobulletin202419042128

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INFLUENCE OF ENZYMATIC ACTIVITY OF MICROBIOTA ON HEMODYNAMICS, ARTERIAL STIFFNESS AND EMOTIONAL STATE OF PATIENTS WITH MILD-TO-MODERATE RISK OF CARDIOVASCULAR COMPLICATIONS
INFLUENCE OF ENZYMATIC ACTIVITY OF MICROBIOTA ON HEMODYNAMICS, ARTERIAL STIFFNESS AND EMOTIONAL STATE OF PATIENTS WITH MILD-TO-MODERATE RISK OF CARDIOVASCULAR COMPLICATIONS

To cite this article:

Smirnova MD, Svirida ON, Blankova ZN, Vitsenya MV, Ivanova AYu, Ageev FT, Medvedev OS. Influence of enzymatic activity of microbiota on hemodynamics, arterial stiffness and emotional state of patients with mild-to-moderate risk of cardiovascular complications. Russian Cardiology Bulletin. 2024;19(4‑2):128‑136. (In Russ.)
https://doi.org/10.17116/Cardiobulletin202419042128

Подписка 2025-2 (Russian Cardiology Bulletin)
 
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Over the last 10 years, many studies were devoted to the role of intestinal microbiota and their metabolites in pathogenesis of cardiovascular diseases.

OBJECTIVE

To estimate the influence of enzymatic activity of microbiota on hemodynamics, arterial stiffness and emotional state of patients with mild-to-moderate risk of cardiovascular complications.

MATERIAL AND METHODS

The study included 22 patients with mild-to-moderate risk of cardiovascular complications. In addition to standard examination, patients underwent volumetric sphygmography with analysis of cardio-ankle vascular index, HADS scores and results of hydrogen-methane breath test with lactulose.

RESULTS

CH4-releasing microflora predominated in 7 patients, H2- releasing microflora — in 15 cases. Multivariate regression analysis revealed negative correlation between systolic blood pressure and CH4 level (r=–0.530; p=0.008). CH4 AUC was an age-independent predictor of higher systolic blood pressure (β=–0.49; p=0.03). There was a negative correlation between anxiety and H2 (r=–0.44; p=0.05), as well as H2/CH4 ratio (r=–0.53; p=0.02). H2 level was a negative predictor of anxiety independent of age, systolic and diastolic blood pressure, as well as heart rate (β=–0.64; p<0.01). There was a negative correlation between CAVI and exhaled H2 (r=–0.41; p<0.05).

CONCLUSION

Hydrogen-methane breath test may be advisable for more accurate assessment of risk of cardiovascular complications and their personalized prevention.

Keywords:

gut microbiota
arterial hypertension
anxiety
arterial stiffness
cardiovascular risk stratification

Authors:

Smirnova M.D.

Chazov National Medical Research Center of Cardiology

Svirida O.N.

Chazov National Medical Research Center of Cardiology

Blankova Z.N.

Chazov National Medical Research Center of Cardiology

Vitsenya M.V.

Chazov National Medical Research Center of Cardiology

Ivanova A.Yu.

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

Ageev F.T.

Chazov National Medical Research Center of Cardiology

Medvedev O.S.

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

Received:

18.01.2024

Accepted:

19.04.2024

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