Transforming growth factor beta in patients with cervical artery dissection

Kalashnikova L.A.; Danilova M.S.; Shabalina A.A.; Gubanova M.V.; Shamtieva K.V.; Dreval M.V.; Dobrynina L.A.

doi:https://doi.org/10.17116/jnevro202212210182

Kalashnikova L.A.

Research Center of Neurology

ORCID: 0000-0003-1142-0548

Danilova M.S.

Research Center of Neurology

Shabalina A.A.

Research Center of Neurology

SPIN RSCI: 9414-9068
Scopus AuthorID: 59097027100
ResearcherID: B-2504-2018
ORCID: 0000-0001-9604-7775

Gubanova M.V.

Research Center of Neurology

Shamtieva K.V.

Research Center of Neurology

Dreval M.V.

Research Center of Neurology

Dobrynina L.A.

Research Center of Neurology

ORCID: 0000-0001-9929-2725

Transforming growth factor beta in patients with cervical artery dissection

Authors:

Kalashnikova L.A., Danilova M.S., Shabalina A.A., Gubanova M.V., Shamtieva K.V., Dreval M.V., Dobrynina L.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10): 82‑87

DOI: 10.17116/jnevro202212210182

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To cite this article:

Kalashnikova LA, Danilova MS, Shabalina AA, Gubanova MV, Shamtieva KV, Dreval MV, Dobrynina LA. Transforming growth factor beta in patients with cervical artery dissection. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10):82‑87. (In Russ.)
https://doi.org/10.17116/jnevro202212210182

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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OBJECTIVE

To evaluate transforming growth factor beta (TGF-β) in patients with cervical artery dissection (CeAD).

MATERIAL AND METHODS

TGF-β was studied by enzyme immunoassay in 74 of 336 patients with CeAD observed at the Research Center of Neurology (Moscow) from 2000 to 2021. The average patient’s age at the time of TGF-β study was 41.6±9.8 years; the proportion of women was 51%. TGF-β was studied in the first month of the disease (n=9), for 2—3 months (n=12) and at a later period (mean — 4.3±5.03 years) (n=53). The control group consisted of 20 healthy volunteers, matched for age and sex. Dissection occurred in internal carotid artery (ICA) (n=42), vertebral artery (VA) (n=29), ICA+VA (n=3) and involved 1 artery (n=58) or 2—3 arteries (n=16). Clinical manifestations included ischemic stroke (IS) (n=49), isolated cervical-cephalic headache (n=23), lower cranial nerve palsy (n=2). Pathological CeAD tortuosity was detected by angiography in 13 patients, and a dissecting aneurysm in 15 patients.

RESULTS

TGF-β1 and TGF-β2 were elevated in patients with CeAD patients compared with the control: TGF-β1 — 4990 [3950; 7900] pg/ml vs. 3645 [3230; 4250] pg/ml, p=0.001; TGF-β2 — 6120 [4680; 7900] pg/ml vs. 3155 [2605; 4605] pg/ml, p=0.001. The highest TGF-β1 and TGF-β2 levels were noted at 2—3 months of the disease. There was no correlation between the TGF-β level and various clinical and angiographic parameters.

CONCLUSION

Increased TGF-β level confirms that CeAD patients have connective tissue disorder that underlies the arterial wall weakness. A higher TGF-β level at 2—3 months of CeAD seems to be connected with an active reparative process in arterial wall after dissection. TGF-β can be used as a biomarker of connective tissue dysplasia in patients with CeAD.

Keywords:

TGF-β

connective tissue dysplasia

dissection

ischemic stroke

young age

Authors:

Kalashnikova L.A.

Research Center of Neurology

ORCID: 0000-0003-1142-0548

Danilova M.S.

Research Center of Neurology

Shabalina A.A.

Research Center of Neurology

SPIN RSCI: 9414-9068
Scopus AuthorID: 59097027100
ResearcherID: B-2504-2018
ORCID: 0000-0001-9604-7775

Gubanova M.V.

Research Center of Neurology

Shamtieva K.V.

Research Center of Neurology

Dreval M.V.

Research Center of Neurology

Dobrynina L.A.

Research Center of Neurology

ORCID: 0000-0001-9929-2725

Received:

20.04.2022

Accepted:

08.07.2022

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References:

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