A personalized genetic approach to surgical treatment of carotid artery tortuosity

Gavrilenko A.V.; Zaklyazminskay E.V.; Rumyantsev V.A.; Abramyan A.V.; Savieva A.S.

doi:https://doi.org/10.17116/kardio202417041436

Gavrilenko A.V.

Russian Scientific Center for Surgery named after Academician B.V. Petrovsky;
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

ORCID: 0000-0001-7267-7369

Zaklyazminskay E.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-6244-9546

Rumyantsev V.A.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-3224-8097

Abramyan A.V.

Russian Scientific Center for Surgery named after Academician B.V. Petrovsky

ORCID: 0000-0003-1091-2639

Savieva A.S.

Russian University of Medicine

ORCID: 0009-0007-0656-7365

A personalized genetic approach to surgical treatment of carotid artery tortuosity

Authors:

Gavrilenko A.V., Zaklyazminskay E.V., Rumyantsev V.A., Abramyan A.V., Savieva A.S.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(4): 436‑444

DOI: 10.17116/kardio202417041436

Read: 1011 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Gavrilenko AV, Zaklyazminskay EV, Rumyantsev VA, Abramyan AV, Savieva AS. A personalized genetic approach to surgical treatment of carotid artery tortuosity. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(4):436‑444. (In Russ.)
https://doi.org/10.17116/kardio202417041436

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Risk factors of internal carotid artery tortuosity. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(2):150-155

Surgical significance of various types of internal carotid artery tortuosity. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(4):392-398

Surgical significance of quantitative assessment of carotid artery tortuosity. Pirogov Russian Journal of Surgery. 2025;(3):63-68

Study of the role of interleukin-1β in blood serum in patients with acne. Russian Journal of Clinical Dermatology and Venereology. 2025;(4):421-424

Combination of gothic palate and pes cavus — pattern or coincidence?. Russian Journal of Stomatology. 2025;(3):74-80

Abstract:

Internal carotid artery tortuosity implies deformation (uneven course with bending, looping and twisting) of carotid artery supplying the brain. These processes affect blood flow. In recent decades, many studies were devoted to mechanisms of carotid artery tortuosity. One of the important aspects is genetic factors that may be essential in this pathological process. In this review, we will consider the known genetic mechanisms underlying occurrence and progression of carotid artery tortuosity.

Keywords:

carotid artery

tortuosity

hereditary diseases

connective tissue dysplasia

Authors:

Gavrilenko A.V.

ORCID: 0000-0001-7267-7369

Zaklyazminskay E.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-6244-9546

Rumyantsev V.A.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-3224-8097

Abramyan A.V.

Russian Scientific Center for Surgery named after Academician B.V. Petrovsky

ORCID: 0000-0003-1091-2639

Savieva A.S.

Russian University of Medicine

ORCID: 0009-0007-0656-7365

Received:

01.03.2024

Accepted:

31.03.2024

Close metadata

References:

Danilova MA, Baidina TV, Karakulova YuV et al. Pathological tortuosity of carotid arteries. Perm Medical Journal. 2018;35(6):82-89. (In Russ.).
Gavrilenko AV, Kochetkov VA, Kuklin AV, Abramyan AV. Surgical treatment of carotid artery kinking. Pirogov Russian Journal of Surgery. 2013;(6):88-91. (In Russ.).
Belov YuV. Symptoms and diagnosis of internal carotid artery tortuosity. Guide to vascular surgery with atlas of surgical techniques. M. 2000;167-182. (In Russ.).
Gavrilenko AV, Abramyan AB, Kuklin AV. Comparative analysis of surgical and conservative treatment of patients with carotid artery tortuosity. Angiology and Vascular Surgery. 2012;18(4):93-99. (In Russ.).
Pancera P. Prevalence of carotid artery kinking in 590 consecutive subjects evaluated by Echocolordoppler. Is there a correlation with arterial hypertension? Journal of Internal Medicine. 2010;248:7-12.
Cronenwett JL, Johnston KW. Rutherford’s vascular surgery. Philadelphia: Saunders; 2010.
Desai B, Toole JF. Kinks, coils and carotids: a review. Stroke. 1975;6:649-653.
Rodin YuV. Study of blood flow in S-shaped carotid artery tortuosity. International Journal of Neurology. 2006;4(8):25-28. (In Russ.).
Leipzig TJ. et al. The tortuous or kinked carotid clinical considerations artery: pathogenesis and clinical considerations. Surgical Neurology. 1986;25:478-486.
Weibel J, Fields WS. Tortuosity, coiling and kinking of the internalcarotid artery. Relationship of morphological variation to cerebrovascular insufficiency. Neurology. 1965;15:462-468.
Kovaleva YaB. Combination of deformations of internal carotid arteries and stroke. Bulletin of municipal health care. 2011;6. (In Russ.).
Barbera GL, et al. Kinking, coiling, and tortuosity of extracranial internal carotid artery: is it the effect of a metaplasia? Surg Radiol Anat. 2006;28:573-580.
Grin VK. Carotid artery tortuosity as a cause of neurological symptoms and surgical correction. Neuroscience: theoretical and practical aspects. 2007;3(1-2):93-96. (In Russ.).
Danilova MA, Baidina TV, Danilov VN. Additional methods for diagnosis of unstable atherosclerotic plaque in carotid arteries. Angiology and Vascular Surgery. 2014;20(3):37-39. (In Russ.).
Trisvetova EL. Modern concepts of fibromuscular dysplasia of coronary arteries. Rational Pharmacotherapy in Cardiology. 2019;15(3):431-438. (In Russ.). https://doi.org/10.20996/1819-6446-2019-15-3-431-438
Baradhi KM, Bream P. Fibromuscular Dysplasia. StatPearls Publishing; 2023.
Shah KP, Peruri A, Kanneganti M, et al. Fibromuscular dysplasia: A comprehensive review on evaluation and management and role for multidisciplinary comprehensive care and patient input model. Semin Vasc Surg. 2021;34(1):89-96. https://doi.org/10.1053/j.semvascsurg.2021.02.009
Coelho SG, Almeida AG. Marfan syndrome revisited: From genetics to the clinic. Rev Port Cardiol (Engl Ed). 2020;39(4):215-226. https://doi.org/10.1016/j.repc.2019.09.008
Riley B. The Many Facets of Hypermobile Ehlers-Danlos Syndrome. J Am Osteopath Assoc. 2020;120(1):30-32. https://doi.org/10.7556/jaoa.2020.012
Vairo FPE, Chwal BC, Perini S, Ferreira MAP, de Freitas Lopes AC, Saute JAM. A systematic review and evidence-based guideline for diagnosis and treatment of Menkes disease. Mol Genet Metab. 2019; 126(1):6-13. https://doi.org/10.1016/j.ymgme.2018.12.005
Voloshina NB, Osipenko MF, Litvinova NV, Voloshin AN. Hemochromatosis — modern condition of the problem. Ter Arkh. 2018;90(3):107-112. https://doi.org/10.26442/terarkh2018903107-112
Kalashnikova LA, Danilova MS, Gubanova MV, Dreval MV, Dobrynina LA, Chechetkin AO. Internal carotid artery dissection in patients with Turner’s syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8-2):58-65. (In Russ.). https://doi.org/10.17116/jnevro202112108258
Welby JP, Kim ST, Carr CM, et al. Carotid Artery Tortuosity Is Associated with Connective Tissue Diseases. American Journal of Neuroradiology. 2019;40(10):1738-1743. https://doi.org/10.3174/ajnr.A6218
Koskas F, Kieffer A, Kiffer E, et al. Loops and folds of the carotid and vertebral arteries: indication for surgery. J Malad Vascul. 1994;19(supl A):51-54.
Kulikov VP, Khoreev NG, Gerasimenko IN, et al. Doppler scanning of blood vessels in diagnosis of carotid artery tortuosity. Echography. 2000;2:147-154. (In Russ.).
Van Laarhoven CJ, Willemsen SI, Klaassen J, et al. Carotid Aneurysm Registry (CAR) study group. Carotid tortuosity is associated with extracranial carotid artery aneurysms. Quant Imaging Med Surg. 2022;12(11):5018-5029. https://doi.org/10.21037/qims-22-89
Koge J, Tanaka K, Yoshimoto T, et al. Internal Carotid Artery Tortuosity: Impact on Mechanical Thrombectomy. Stroke. 2022;53(8):2458-2467. https://doi.org/10.1161/STROKEAHA.121.037904
Wali AR, Santiago-Dieppa DR, Steinberg JA, Alattar A, Cheung VJ, Modir R, Khalessi AA, Pannell JS. Hypoplastic Internal Carotid Artery Co-Presenting with Neurofibromatosis and Intracranial Masses. Cureus. 2016;8(8):e750. https://doi.org/10.7759/cureus.750
Brissot P, Pietrangelo A, Adams PC, de Graaff B, McLaren CE, Loréal O. Haemochromatosis. Nat Rev Dis Primers. 2018;4:18016. https://doi.org/10.1038/nrdp.2018.16
Gałąska R, Kulawiak-Gałąska D, Chmara M, Chlebus K, Mickiewicz A, Rynkiewicz A, Wasąg B, Studniarek M, Fijałkowski M, Gruchała M. Carotid intima-media thickness (IMT) in patients with severe familial and non-familial hypercholesterolemia: The effect of measurement site on the IMT correlation with traditional cardiovascular risk factors and calcium scores. Cardiol J. 2021;28(2):271-278. https://doi.org/10.5603/CJ.a2020.0032
Kuroda S, Fujimura M, Takahashi J, Kataoka H, Ogasawara K, Iwama T, Tominaga T, Miyamoto S; Research Committee on Moyamoya Disease (Spontaneous Occlusion of Circle of Willis) of the Ministry of Health, Labor, and Welfare, Japan. Diagnostic Criteria for Moyamoya Disease — 2021 Revised Version. Neurol Med Chir (Tokyo). 2022;62(7):307-312. https://doi.org/10.2176/jns-nmc.2022-0072
Ivanova NI, Tsalta-Mladenov ME, Georgieva DK, Andonova SP. Central Pontine Myelinolysis as a Late Complication After Hyponatremia and COVID-19 Infection. Cureus. 2023;15(2):e35191. https://doi.org/10.7759/cureus.35191
Urbanski PP, Hacker RW. Replacement of the aortic valve and ascending aorta with a valved stentless composite graft: technical considerations and early clinical results. Ann Thorac Surg. 2000;70(1):17-20. https://doi.org/10.1016/s0003-4975(00)01482-x
Indja B, Seco M, Seamark R, Kaplan J, Bannon PG, Grieve SM, Vallely MP. Neurocognitive and Psychiatric Issues Post Cardiac Surgery. Heart Lung Circ. 2017;26(8):779-785. https://doi.org/10.1016/j.hlc.2016.12.010
Belov YuV, Medvedeva LA, Zagorulko OI, Charchyan ER, Drakina OV. Cognitive disorders in early and late periods in patients after carotid endarterectomy. Surgery. Journal named after N.I. Pirogov. 2018;12:5-12.
Charchyan ER, Stepanenko AB, Belov YuV, Gens AP, Kabanova MN, Turaev MM. Single-stage surgical interventions on the coronary and carotid basins in the treatment of multifocal atherosclerosis. Cardiology. 2014;54(9): 46-51.