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Zakharova K.V.

Serbsky National Medical Research Centre for Psychiatry and Narcology, the Ministry of Health of the Russian Federation

A Arkushae I.

Serbsky National Medical Research Centre for Psychiatry and Narcology, the Ministry of Health of the Russian Federation

Akzhigitov R.G.

Moscow Research and Clinical Center for Neuropsychiatry

Avedisova A.S.

Serbsky National Medical Research Centre for Psychiatry and Narcology, the Ministry of Health of the Russian Federation

Transdiagnostic approach to negative symptoms

Authors:

Zakharova K.V., A Arkushae I., Akzhigitov R.G., Avedisova A.S.

More about the authors

Read: 3208 times


To cite this article:

Zakharova KV, A Arkushae I, Akzhigitov RG, Avedisova AS. Transdiagnostic approach to negative symptoms. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1):23‑30. (In Russ.)
https://doi.org/10.17116/jnevro202212201123

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References:

  1. Kirkpatrick B. Developing concepts in negative symptoms: primary vs secondary and apathy vs expression. J Clin Psychiatry. 2014;75(suppl 1):3-7.  https://doi.org/10.4088/JCP.13049su1c.01
  2. Reynolds JR. On the pathology of convulsions, with special reference to those children. Liverpool Med Chir J. 1858;2:1-14.  https://doi.org/10.1177/0957154X9800903607
  3. Spencer H. Synthetic Philosophy. Principles of Psychology. 1855.
  4. Jackson JH. Selected writings of John Hughlings Jackson. Staples. 1958.
  5. Kraepelin E. Lehrbuch der Psychiatrie. V Aufl. Leipzig. 1896.
  6. Bleuler E. Dementia praecox oder Gruppe der Schizophrenien. Deuticke. 1911.
  7. Jaspers K. General psychopathology. JHU Press. 1997.
  8. Schneider K. Primäre und sekundäre Symptome bei der Schizophrenic. Fortschr Neur Psychiat. 1957;9:487-490. 
  9. Crow TJ. Positive and negative schizophrenic symptoms and the role of dopamine. The British Journal of Psychiatry. 1980;137(4):383-386.  https://doi.org/10.1192/S0007125000071919
  10. Andreasen NC, Olsen S. Negative v positive schizophrenia. Definition and validation. Arch Gen Psychiatry. 1982;39:789.  https://doi.org/10.1001/archpsyc.1982.04290070025006
  11. Snezhnevskii AV. Schizophrenia (clinical picture and pathogenesis). 1969;5-28. (In Russ.).
  12. Carpenter WT, Heinrichs DW, Wagman AMI. Deficit and nondeficit forms of schizophrenia: The concept. Am J Psychiatry. 1988;145:578-583.  https://doi.org/10.1176/ajp.145.5.578
  13. Kirkpatrick B, Buchanan RW, Ross DE, Carpenter WT Jr. A separate disease within the syndrome of schizophrenia. Arch Gen Psychiatry. 2001;58(2):165-171.  https://doi.org/10.1001/archpsyc.58.2.165
  14. Kring AM, Gur RE, Blanchard JJ, Horan WP, Reise SP. The Clinical Assessment Interview for Negative Symptoms (CAINS): final development and validation. Am J Psychiatry. 2013;170(2):165-172.  https://doi.org/10.1176/appi.ajp.2012.12010109
  15. Strauss GP, Keller WR, Buchanan RW, et al. Next-generation negative symptom assessment for clinical trials: validation of the Brief Negative Symptom Scale. Schizophr Res. 2012;142(1-3):88-92.  https://doi.org/10.1016/j.schres.2012.10.012
  16. Trémeau F, Goggin M, Antonius D, Czobor P, Hill V, Citrome L. A new rating scale for negative symptoms: the Motor-Affective-Social Scale. Psychiatry Res. 2008;160(3):346-355.  https://doi.org/10.1016/j.psychres.2007.06.021
  17. Cohen AS, Alpert M, Nienow TM, Dinzeo TJ, Docherty NM. Computerized measurement of negative symptoms in schizophrenia. J Psychiatr Res. 2008;42(10):827-836.  https://doi.org/10.1016/j.jpsychires.2007.08.008
  18. Kaiser S, Heekeren K, Simon JJ. The negative symptoms of schizophrenia: category or continuum? Psychopathology. 2011;44(6):345-353.  https://doi.org/10.1159/000325912
  19. Marder SR, Galderisi S. The current conceptualization of negative symptoms in schizophrenia. World Psychiatry. 2017;16(1):14-24.  https://doi.org/10.1002/wps.20385
  20. Spitzer RL, Endicott J, Robins E. Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry. 1978;35(6):773-782.  https://doi.org/10.1001/archpsyc.1978.01770300115013
  21. Pogue-Geile MF, Harrow M. Negative and positive symptoms in schizophrenia and depression: a followup. Schizophr Bull. 1984;10(3):371-387.  https://doi.org/10.1093/schbul/10.3.371
  22. Gerbaldo H, Helisch A, Schneider B, Philipp M, Benkert O. Subtypes of negative symptoms: the primary subtype in schizophrenic and non-schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994;18(2):311-320.  https://doi.org/10.1016/0278-5846(94)90062-0
  23. Huber G, Gross G, Schüttler R. Schizophrenie. Berlin: Springer; 1979.
  24. Bleuler E. Lehrbuch der Psychiatrie. from M. Bleuler. 1972.
  25. Donnoli VF, Moroni MV, Cohen D, Chisari Rocha L, Marleta M, Sepich Dalmeida T, Bonani M, D’Alessio L. Negative symptoms in patients with non schizophrenic psychiatric disorders. Vertex. 2011;22(98):262-267. 
  26. Chaturvedi SK, Rao GP, Mathai PJ, Sarmukaddam S, Gopinath PS. Negative symptoms in schizophrenia and depression. Indian J Psychiatry. 1985;27(3):237-241. 
  27. Bottlender R, Sato T, Groll C, Jäger M, Kunze I, Möller HJ. Negative symptoms in depressed and schizophrenic patients: how do they differ? J Clin Psychiatry. 2003;64(8):954-958.  https://doi.org/10.4088/jcp.v64n0816
  28. Galynker II, Cohen LJ, Cai J. Negative symptoms in patients with major depressive disorder: a preliminary report. Neuropsychiatry Neuropsychol Behav Neurol. 2000;13(3):171-176. 
  29. Gard DE, Kring AM, Gard MG, Horan WP, Green MF. Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophr Res. 2007;93(1-3):253-260.  https://doi.org/10.1016/j.schres.2007.03.008
  30. Buck B, Lysaker PH. Consummatory and anticipatory anhedonia in schizophrenia: stability, and associations with emotional distress and social function over six months. Psychiatry Res. 2013;205(1-2):30-35.  https://doi.org/10.1016/j.psychres.2012.09.008
  31. Richter J, Hölz L, Hesse K, Wildgruber D, Klingberg S. Measurement of negative and depressive symptoms: Discriminatory relevance of affect and expression. Eur Psychiatry. 2019;55:23-28.  https://doi.org/10.1016/j.eurpsy.2018.09.008
  32. Watson D, Clark LA. Negative affectivity: the disposition to experience aversive emotional states. Psychol Bull. 1984;96(3):465-490.  https://doi.org/10.1037/0033-2909.96.3.465
  33. Smulevich AB, Dubnitskaya EB, Tkhostov ASh. Psychopathology of depression (towards the construction of a typological model). Depression and Comorbid Disorders. 1997;28-54. (In Russ.).
  34. Strauss GP, Vertinski M, Vogel SJ, Ringdahl EN, Allen DN. Negative symptoms in bipolar disorder and schizophrenia: A psychometric evaluation of the brief negative symptom scale across diagnostic categories. Schizophr Res. 2016;170(2-3):285-289.  https://doi.org/10.1016/j.schres.2015.12.014
  35. Herbener ES, Harrow M. Longitudinal assessment of negative symptoms in schizophrenia/schizoaffective patients, other psychotic patients, and depressed patients. Schizophr Bull. 2001;27(3):527-537.  https://doi.org/10.1093/oxfordjournals.schbul.a006893
  36. Mundt C, Kasper S, Huerkamp M. The diagnostic specificity of negative symptoms and their psychopathological context. Br J Psychiatry Suppl. 1989;(7):32-40.  https://doi.org/10.1192/s0007125000291447
  37. Chase TN. Apathy in neuropsychiatric disease: diagnosis, pathophysiology, and treatment. Neurotoxicity Research. 2011;19(2):266-278.  https://doi.org/10.1007/s12640-010-9196-9
  38. Stanton BR, Leigh PN, Howard RJ, Barker GJ, Brown RJ. Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders. Journal of Neurology. 2013;260(10):2481-2490. https://doi.org/10.1007/s00415-013-6989-9
  39. Avedisova AS, Gueht AB, Zakharova KV, Dashkina GK, Popov GR. Apathy in the structure of mental and neurological disorders of late age. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2014;114:6:77-85. (In Russ.).
  40. Varanese S, Perfetti B, Ghilardi MF, Di Rocco A. Apathy, but not depresson reflects inefficient cognitive strategies in Parkinson’s disease. PLoS One. 2011;6:3:17846. https://doi.org/10.1371/journal.pone.0017846
  41. Isella V, Melzi P, Grimaldi M, Iurlaro S, Piolti R, Ferrarese C, Frattola L, Appollonio I. Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson’s disease. Movement Disorders. 2002;7:366-371.  https://doi.org/10.1002/mds.10041
  42. Zhou Z, Müller MLTM, Kanel P, Chua J, Kotagal V, Kaufer DI, Albin RL, Frey KA, Bohnen NI. Apathy rating scores and β-amyloidopathy in patients with Parkinson disease at risk for cognitive decline. Neurology. 2020;94(4):376-383.  https://doi.org/10.1212/WNL.0000000000008683
  43. Marin RS. Differential diagnosis and classification of apathy. Am J Psychiatry. 1990;147(1):22-30.  https://doi.org/10.1176/ajp.147.1.22
  44. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991;3(3):243-254.  https://doi.org/10.1176/jnp.3.3.243
  45. Bermanzohn PC, Siris SG. Akinesia: a syndrome common to parkinsonism, retarded depression, and negative symptoms of schizophrenia. Compr Psychiatry. 1992;33(4):221-232.  https://doi.org/10.1016/0010-440x(92)90045-r
  46. Hallett M, Khoshbin S. A physiological mechanism of bradykinesia. Brain. 1980;103(2):301-314.  https://doi.org/10.1093/brain/103.2.301
  47. Isenberg C, Conrad B. Kinematic properties of slow arm movements in Parkinson’s disease. J Neurol. 1994;241(5):323-330.  https://doi.org/10.1007/bf00868441
  48. Caligiuri MP, Lohr JB, Ruck RK. Scaling of movement velocity: a measure of neuromotor retardation in individuals with psychopathology. Psychophysiology. 1998;35(4):431-437.  https://doi.org/10.1111/1469-8986.3540431
  49. Jogems-Kosterman BJ, Zitman FG, Van Hoof JJ, Hulstijn W. Psychomotor slowing and planning deficits in schizophrenia. Schizophr Res. 2001;48(2-3):317-333.  https://doi.org/10.1016/s0920-9964(00)00097-9
  50. Rogers MA, Bradshaw JL, Phillips JG, Chiu E. Reliance on external cues during serial sequential movement in major depression. J Neurol Neurosurg Psychiatry. 2000;69(2):237-239.  https://doi.org/10.1136/jnnp.69.2.237
  51. Benecke R, Rothwell JC, Dick JP, Day BL, Marsden CD. Disturbance of sequential movements in patients with Parkinson’s disease. Brain. 1987;110(2):361-379.  https://doi.org/10.1093/brain/110.2.361
  52. Sachdev P, Aniss AM. Slowness of movement in melancholic depression. Biol Psychiatry. 1994;35(4):253-262.  https://doi.org/10.1016/0006-3223(94)91256-4
  53. Bradshaw J (Ed.), Enticott P (Ed.). Developmental Disorders of the Frontostriatal System. London: Psychology Press; 2001. https://doi.org/10.4324/9781315782966
  54. Winograd-Gurvich C, Fitzgerald PB, Georgiou-Karistianis N, Bradshaw JL, White OB. Negative symptoms: A review of schizophrenia, melancholic depression and Parkinson’s disease. Brain Res Bull. 2006;70(4-6):312-321.  https://doi.org/10.1016/j.brainresbull.2006.06.007
  55. Brown RG, Pluck G. Negative symptoms: the ‘pathology’ of motivation and goal-directed behaviour. Trends Neurosci. 2000;23(9):412-417.  https://doi.org/10.1016/s0166-2236(00)01626-x
  56. Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, Feiner D, Rotrosen J, Wolkin A. Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms. Arch Gen Psychiatry. 2000;57(5):471-480.  https://doi.org/10.1001/archpsyc.57.5.471
  57. Rogers MA, Bradshaw JL, Pantelis C, Phillips JG. Frontostriatal deficits in unipolar major depression. Brain Res Bull. 1998;47(4):297-310.  https://doi.org/10.1016/s0361-9230(98)00126-9
  58. Ma N, Li L, Shu N, Liu J, Gong G, et al. White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder. Am J Psychiatry. 2007;164:823-826.  https://doi.org/10.1176/ajp.2007.164.5.823
  59. Isella V, Melzi P, Grimaldi M, Iurlaro S, Piolti R, Ferrarese C, Frattola L, Appollonio I. Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson’s disease. Mov Disord. 2002;17(2):366-371.  https://doi.org/10.1002/mds.10041
  60. Kirschner M, Hager OM, Bischof M, Hartmann MN, Kluge A, Seifritz E, Tobler PN, Kaiser S. Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia. J Psychiatry Neurosci. 2016;41(3):152-161.  https://doi.org/10.1503/jpn.140383
  61. Galderisi S, Merlotti E, Mucci A. Neurobiological background of negative symptoms. Eur Arch Psychiatry Clin Neurosci. 2015;265(7):543-558.  https://doi.org/10.1007/s00406-015-0590-4
  62. Bhatia KP, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain. 1994;117(4):859-876.  https://doi.org/10.1093/brain/117.4.859
  63. Finset A, Andersson S. Coping strategies in patients with acquired brain injury: relationships between coping, apathy, depression and lesion location. Brain Inj. 2000;14(10):887-905.  https://doi.org/10.1080/026990500445718
  64. Paradiso S, Chemerinski E, Yazici KM, Tartaro A, Robinson RG. Frontal lobe syndrome reassessed: comparison of patients with lateral or medial frontal brain damage. J Neurol Neurosurg Psychiatry. 1999;67(5):664-667.  https://doi.org/10.1136/jnnp.67.5.664
  65. Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, Fukuda R, Ron M, Toone B. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am J Psychiatry. 2001;158(2):234-243.  https://doi.org/10.1176/appi.ajp.158.2.234
  66. Anderson JE, Wible CG, McCarley RW, Jakab M, Kasai K, Shenton ME. An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia. Schizophr Res. 2002;58(2-3):123-134.  https://doi.org/10.1016/s0920-9964(01)00372-3
  67. Andreasen NC, Olsen SA, Dennert JW, Smith MR. Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms. Am J Psychiatry. 1982;139(3):297-302.  https://doi.org/10.1176/ajp.139.3.297
  68. Nibuya M, Kanba S, Sekiya U, et al. Schizophrenic patients with deficit syndrome have higher plasma homovanillic acid concentrations and ventricular enlargement. Biol Psychiatry. 1995;38(1):50-56.  https://doi.org/10.1016/0006-3223(94)00216-p
  69. Lavretsky H, Ballmaier M, Pham D, Toga A, Kumar A. Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Am J Geriatr Psychiatry. 2007;15(5):386-394.  https://doi.org/10.1097/jgp.0b013e3180325a16
  70. Reijnders JS, Scholtissen B, Weber WE, Aalten P, Verhey FR, Leentjens AF. Neuroanatomical correlates of apathy in Parkinson’s disease: A magnetic resonance imaging study using voxel-based morphometry. Mov Disord. 2010;25(14):2318-2325. https://doi.org/10.1002/mds.23268
  71. Kostić VS, Filippi M. Neuroanatomical correlates of depression and apathy in Parkinson’s disease: magnetic resonance imaging studies. J Neurol Sci. 2011;310(1-2):61-63.  https://doi.org/10.1016/j.jns.2011.05.036
  72. Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RS, Dolan RJ. The anatomy of melancholia — focal abnormalities of cerebral blood flow in major depression. Psychol Med. 1992;22(3):607-615.  https://doi.org/10.1017/s003329170003806x
  73. Drevets WC. Functional neuroimaging studies of depression: the anatomy of melancholia. Annu Rev Med. 1998;49:341-361.  https://doi.org/10.1146/annurev.med.49.1.341
  74. Galynker II, Cai J, Ongseng F, Finestone H, Dutta E, Serseni D. Hypofrontality and negative symptoms in major depressive disorder. J Nucl Med. 1998;39(4):608-612.  https://doi.org/10.1016/0006-3223(96)84295-8
  75. Grafton ST. Contributions of functional imaging to understanding parkinsonian symptoms. Curr Opin Neurobiol. 2004;14(6):715-719.  https://doi.org/10.1016/j.conb.2004.10.010
  76. Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RS. Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry. 1992;160:179-186.  https://doi.org/10.1192/bjp.160.2.179
  77. Schröder J, Buchsbaum MS, Siegel BV, Geider FJ, Niethammer R. Structural and functional correlates of subsyndromes in chronic schizophrenia. Psychopathology. 1995;28(1):38-45.  https://doi.org/10.1159/000284898
  78. Wolkin A, Sanfilipo M, Wolf AP, Angrist B, Brodie JD, Rotrosen J. Negative symptoms and hypofrontality in chronic schizophrenia. Arch Gen Psychiatry. 1992;49(12):959-965.  https://doi.org/10.1001/archpsyc.1992.01820120047007
  79. Caravaggio F, Fervaha G, Menon M, Remington G, Graff-Guerrero A, Gerretsen P. The neural correlates of apathy in schizophrenia: An exploratory investigation. Neuropsychologia. 2018;118(Pt B):34-39.  https://doi.org/10.1016/j.neuropsychologia.2017.10.027
  80. Busatto GF, Kerwin RW. Schizophrenia, psychosis, and the basal ganglia. Psychiatr Clin North Am. 1997;20(4):897-910.  https://doi.org/10.1016/s0193-953x(05)70351-8
  81. Lafer B, Renshaw PF, Sachs GS. Major depression and the basal ganglia. Psychiatr Clin North Am. 1997;20(4):885-896.  https://doi.org/10.1016/s0193-953x(05)70350-6
  82. Kotov R, Krueger RF, Watson D, Achenbach TM, Althoff RR, Bagby RM, Brown TA, Carpenter WT, Caspi A, Clark LA, Eaton NR, Forbes MK, Forbush KT, Goldberg D, Hasin D, Hyman SE, Ivanova MY, Lynam DR, Markon K, Miller JD, Moffitt TE, Morey LC, Mullins-Sweatt SN, Ormel J, Patrick CJ, Regier DA, Rescorla L, Ruggero CJ, Samuel DB, Sellbom M, Simms LJ, Skodol AE, Slade T, South SC, Tackett JL, Waldman ID, Waszczuk MA, Widiger TA, Wright AGC, Zimmerman M. The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies. J Abnorm Psychol. 2017;126(4):454-477.  https://doi.org/10.31234/osf.io/zaadn
  83. Piamarta F, Iurlaro S, Isella V, Atzeni L, Grimaldi M, Russo A, Forapani E, Appollonio I. Unconventional affective symptoms and executive functions after stroke in the elderly. Arch Gerontol Geriatr Suppl. 2004;(9):315-323.  https://doi.org/10.1016/j.archger.2004.04.042
  84. Alexander GE, Crutcher MD, DeLong MR. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, «prefrontal» and «limbic» functions. Prog Brain Res. 1990;85:119-146.  https://doi.org/10.1016/s0079-6123(08)62678-3
  85. Williams MR, Galvin K, O’Sullivan B, MacDonald CD, Ching EW, Turkheimer F, Howes OD, Pearce RK, Hirsch SR, Maier M. Neuropathological changes in the substantia nigra in schizophrenia but not depression. Eur Arch Psychiatry Clin Neurosci. 2014;264(4):285-296.  https://doi.org/10.1007/s00406-013-0479-z
  86. Moritz S, Fritzsche A, Engel M, Meiseberg J, Klingberg S, Hesse K. A plea for a transdiagnostic conceptualization of negative symptoms and for consistent psychiatric vocabulary. Schizophr Res. 2019;204:427-429.  https://doi.org/10.1016/j.schres.2018.08.027
  87. Meiseberg J, Moritz S. Biases in diagnostic terminology: Clinicians choose different symptom labels depending on whether the same case is framed as depression or schizophrenia. Schizophr Res. 2020;222:444-449.  https://doi.org/10.1016/j.schres.2020.03.050
  88. Upthegrove R, Marwaha S, Birchwood M. Depression and Schizophrenia: Cause, Consequence, or Trans-diagnostic Issue? Schizophr Bull. 2017;43(2):240-244.  https://doi.org/10.1093/schbul/sbw097

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