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Chugunov D.A.

Pirogov Russian National Research Medical University

Smilovich A.A.

Pirogov Russian National Research Medical University

Larina M.R.

Pirogov Russian National Research Medical University

Goncharenko S.N.

Pirogov Russian National Research Medical University

Moiseeva T.V.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow City Department of Health Care

Ryauzova E.S.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow City Department of Health Care

Fedorova E.V.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow City Department of Health Care

Bukinich A.A.

Lomonosov Moscow State University

Clinical and psychometric characteristics of cognitive and negative disorders in schizophrenia

Authors:

Chugunov D.A., Smilovich A.A., Larina M.R., Goncharenko S.N., Moiseeva T.V., Ryauzova E.S., Fedorova E.V., Bukinich A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2): 64‑71

DOI: 10.17116/jnevro202412404264

Read: 2426 times

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Table of contents

CLINICAL AND PSYCHOMETRIC CHARACTERISTICS OF COGNITIVE AND NEGATIVE DISORDERS IN SCHIZOPHRENIA
CLINICAL AND PSYCHOMETRIC CHARACTERISTICS OF COGNITIVE AND NEGATIVE DISORDERS IN SCHIZOPHRENIA

To cite this article:

Chugunov DA, Smilovich AA, Larina MR, et al. Clinical and psychometric characteristics of cognitive and negative disorders in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2):64‑71. (In Russ.)
https://doi.org/10.17116/jnevro202412404264

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To establish the characteristics of clinical manifestations and cognitive tests in patients with schizophrenia, with a predominance of cognitive and negative disorders.

MATERIAL AND METHODS

We examined 76 patients, 66 in the main group, 10 in the comparison group, who were treated in Psychiatric Hospital No. 1 and Psychiatric Hospital No. 4 (Moscow). Clinical-psychopathological, psychometric and statistical methods were used. Features of cognitive functioning were studied using the Frontal Assessment Battery (FAB) and the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis (ALS) Screen (ECAS). Emotional intelligence scores were assessed using the Ekman Face Emotion Recognition (EFER) test.

RESULTS

Patients with schizophrenia showed dominance of one of 3 types of deficit symptoms: cognitive, emotional, and volitional. Cognitive functions were significantly reduced in patients with schizophrenia when compared with the comparison group (mean FAB score (M±SD) 13.44±2.97 in patients with schizophrenia vs. 16.10±1.70 in the comparison group; t=4.10; p<0.001). Cognitive functions were particularly reduced in patients with volitional deficit (mean EFER total score 42.40±9.0 in patients with volitional deficit vs. 47.21±633 in patients with cognitive deficit; t=2.12; p=0.039; mean FAB score 12.83±3.29 in patients with volitional deficit vs. 16.10±1.70 in the comparison group; t=4.24; p<0.001; mean ECAS score specific to ALS 78.80±9.07 in patients with volitional deficit vs. 84.50±6.71 in the comparison group; t=2.18; p=0.034).

CONCLUSION

The greatest contribution to the development of cognitive disorders in schizophrenia is made by dysfunction of frontal (especially) and temporal cortex. Executive functions, speech skills and verbal fluency are most severely damaged.

Keywords:

schizophrenia
cognitive disorders
deficit symptoms
frontal assessment battery (FAB)
Edinburgh Cognitive and Behavioral ALS Screen (ECAS)
Ekman’s Facial Emotion Recognition test (EFER)

Authors:

Chugunov D.A.

Pirogov Russian National Research Medical University

Smilovich A.A.

Pirogov Russian National Research Medical University

Larina M.R.

Pirogov Russian National Research Medical University

Goncharenko S.N.

Pirogov Russian National Research Medical University

Moiseeva T.V.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow City Department of Health Care

Ryauzova E.S.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow City Department of Health Care

Fedorova E.V.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow City Department of Health Care

Bukinich A.A.

Lomonosov Moscow State University

Received:

02.03.2024

Accepted:

07.03.2024

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