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Medvedev V.E.
Peoples’ Friendship University of Russia
Fluvoxamine in the treatment of anxiety-depressive spectrum disorders
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(6): 101‑109
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To cite this article:
Medvedev VE, Kardashian RA, Frolova VI. Fluvoxamine in the treatment of anxiety-depressive spectrum disorders. S.S. Korsakov Journal of Neurology and Psychiatry.
2024;124(6):101‑109. (In Russ.)
https://doi.org/10.17116/jnevro2024124061101
The RSCI and PubMed search databases have requested publications over the past 40 years on the search queries «fluvoxamine», «anxiety-depressive disorders», «anxiety», «depression», «comorbidity», devoted to the effectiveness of fluvoxamine in various variants of disorders of the anxiety-depressive spectrum, anxiety depressions. The data of the above studies indicate that fluvoxamine (Zovart San) in doses of 50-300 mg / day is a highly effective remedy for the treatment of not only anxiety depressions and genesis (psychogenic, organic, mixed, autochthonous-endogenous) and severity (up to psychotic), but also a wider range of anxiety-depressive disorders, including adaptation disorders, obsessive-compulsive disorder, somatized, dysmorphic, insomniac symptom complexes and eating disorders. A wide range of clinical effects of fluvoxamine is due to its main and additional mechanisms of action: blockade of serotonin reuptake, σ1-agonist activity and the effect on the metabolism of melatonin and neurosteroids catabolism.
Keywords:
Authors:
Medvedev V.E.
Peoples’ Friendship University of Russia
Received:
22.05.2024
Accepted:
19.06.2024
List of references:
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