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Kurkin D.V.

Russian University of Medicine;
Volgograd State Medical University

Morkovin E.I.

Volgograd State Medical University

Bakulin D.A.

Russian University of Medicine

Gorbunova Yu.V.

Russian University of Medicine

Ivanova O.V.

Russian University of Medicine

Pavlova E.V.

Russian University of Medicine

Zvereva V.I.

Russian University of Medicine

Dzhavakhyan M.A.

Russian University of Medicine

Krysanov I.S.

Russian University of Medicine

Kolosov Yu.A.

Russian University of Medicine

Zaborovsky A.V.

Russian University of Medicine

Strygin A.V.

Volgograd State Medical University

Petrov V.I.

Volgograd State Medical University

Beliy P.A.

Russian University of Medicine

Zaslavskaya K.Y.

Ogarev National Research Mordovia State University

Maltsev D.V.

Volgograd State Medical University

Skripka M.O.

Volgograd State Medical University

Targeting NMDAR/AMPAR: a promising pharmacotherapeutic approach for depressive disorders

Authors:

Kurkin D.V., Morkovin E.I., Bakulin D.A., Gorbunova Yu.V., Ivanova O.V., Pavlova E.V., Zvereva V.I., Dzhavakhyan M.A., Krysanov I.S., Kolosov Yu.A., Zaborovsky A.V., Strygin A.V., Petrov V.I., Beliy P.A., Zaslavskaya K.Y., Maltsev D.V., Skripka M.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5): 22‑30

DOI: 10.17116/jnevro202412405122

Read: 2734 times

Contact the author
Table of contents

TARGETING NMDAR/AMPAR: A PROMISING PHARMACOTHERAPEUTIC APPROACH FOR DEPRESSIVE DISORDERS
TARGETING NMDAR/AMPAR: A PROMISING PHARMACOTHERAPEUTIC APPROACH FOR DEPRESSIVE DISORDERS

To cite this article:

Kurkin DV, Morkovin EI, Bakulin DA, et al. Targeting NMDAR/AMPAR: a promising pharmacotherapeutic approach for depressive disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5):22‑30. (In Russ.)
https://doi.org/10.17116/jnevro202412405122

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Depression is a leading cause of disability and reduced work capacity worldwide. The monoamine theory of the pathogenesis of depression has remained dominant for many decades, however, drugs developed on its basis have limited efficacy. Exploring alternative mechanisms underlying this pathology could illuminate new avenues for pharmacological intervention. Targeting glutamatergic pathways in the CNS, particularly through modulation of NMDA and AMPA receptors, demonstrates promising results. This review presents some existing drugs with glutamatergic activity and novel developments based on it to enhance the efficacy of pharmacotherapy for depressive disorders.

Keywords:

depression
serotonin
glutamate
NMDA
AMPA
ketamine

Authors:

Kurkin D.V.

Russian University of Medicine;
Volgograd State Medical University

Morkovin E.I.

Volgograd State Medical University

Bakulin D.A.

Russian University of Medicine

Gorbunova Yu.V.

Russian University of Medicine

Ivanova O.V.

Russian University of Medicine

Pavlova E.V.

Russian University of Medicine

Zvereva V.I.

Russian University of Medicine

Dzhavakhyan M.A.

Russian University of Medicine

Krysanov I.S.

Russian University of Medicine

Kolosov Yu.A.

Russian University of Medicine

Zaborovsky A.V.

Russian University of Medicine

Strygin A.V.

Volgograd State Medical University

Petrov V.I.

Volgograd State Medical University

Beliy P.A.

Russian University of Medicine

Zaslavskaya K.Y.

Ogarev National Research Mordovia State University

Maltsev D.V.

Volgograd State Medical University

Skripka M.O.

Volgograd State Medical University

Received:

21.12.2023

Accepted:

23.01.2024

Close metadata

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