Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders

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Melatonin is the most well-known regulator of the circadian rhythms of all living organisms and the main substrate synthesized at night. There are 4 stages in the synthesis of melatonin. This review focuses on the 2nd, 3rd, and 4th stages. The review is aimed at analyzing publications on molecular genetic association studies on the role of single nucleotide polymorphisms (SNPs) of the DDC (AADC), AANAT and ASMT genes encoding melatonin synthesis enzymes in the pathogenesis of socially significant neuropsychiatric disorders in humans. The authors analyzed the available full-text articles from several databases, as well as materials from electronic resources. Search depth was 15 years. The analysis of these studies over the past decade show the association of some SNPs of the studied genes with the risk of neuropsychiatric disorders such as delayed sleep phase disorder, attention deficit hyperactivity disorder, autism spectrum disorder, migraine, Parkinson’s disease, depression, anxiety, bipolar-affective disorder, schizophrenia.

Keywords:

melatonin

synthesis

DDC (AADC)

AANAT

ASMT

single nucleotide polymorphism (SNP)

schizophrenia

depression

anxiety

autism

ADHD

migraine

Authors:

Moskaleva P.V.

Voino-Yasenetsky Krasnoyarsk State Medical University

Shnayder N.A.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Nasyrova R.F.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Received:

28.03.2019

Accepted:

11.06.2019

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