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V Kalmykova G.

Belgorod State National Research University

Chefranova Zh.Yu.

Belgorod Regional Clinical Hospital of St. Joasaph

Rybnikova V.F.

Children’s Regional Clinical Hospital

Zubova K.O.

Children’s Regional Clinical Hospital

Cortexin administration due to improvement of cognitive and behavioral disorders in children and teenagers with epilepsy

Authors:

V Kalmykova G., Chefranova Zh.Yu., Rybnikova V.F., Zubova K.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3): 127‑131

DOI: 10.17116/jnevro2021121031127

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Table of contents

CORTEXIN ADMINISTRATION DUE TO IMPROVEMENT OF COGNITIVE AND BEHAVIORAL DISORDERS IN CHILDREN AND TEENAGERS WITH EPILEPSY
CORTEXIN ADMINISTRATION DUE TO IMPROVEMENT OF COGNITIVE AND BEHAVIORAL DISORDERS IN CHILDREN AND TEENAGERS WITH EPILEPSY

To cite this article:

V Kalmykova G, Chefranova ZhYu, Rybnikova VF, Zubova KO. Cortexin administration due to improvement of cognitive and behavioral disorders in children and teenagers with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3):127‑131. (In Russ.)
https://doi.org/10.17116/jnevro2021121031127

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study the possibility of using the polypeptide drug cortexin for the treatment of cognitive, emotional and behavioral disorders in children and adolescents with epilepsy and to assess the efficacy and safety of the drug in this group of patients.

MATERIALS AND METHODS

Eighty-six patients (41 girls and 45 boys) were examined at the age of 3 to 17 y.o. Cortexin was used along with antiepileptic drugs. Clinical and pathopsychological methods were administered.

RESULTS

Children and teenagers with epilepsy have average IQ (91—110) in 72% of cases, 24% had mental deficiency of various intensity, these were children with pharmacoresistant epilepsy, including 2% with IQ 154 and 2% with IQ 71—80.

CONCLUSION

Clinical, neurophysiological and psychological study of children and adolescents with epilepsy reveal the improvement of electrophysiological parameters, there are no aggravation of seizures in 95% cases. The improvement of cognitive functions is observed in 65% of patients.

Keywords:

cognitive and behavior impairments
epilepsy
children
teenagers
cortexin

Authors:

V Kalmykova G.

Belgorod State National Research University

Chefranova Zh.Yu.

Belgorod Regional Clinical Hospital of St. Joasaph

Rybnikova V.F.

Children’s Regional Clinical Hospital

Zubova K.O.

Children’s Regional Clinical Hospital

Received:

31.08.2020

Accepted:

17.02.2021

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