Differentiated complex treatment of Parkinson’s disease considering atrophic changes of the brain

Chipizubov V.A.; Shprakh V.V.; Petrov S.I.; Mikhalevich I.M.

doi:https://doi.org/10.17116/jnevro202112103139

Chipizubov V.A.

Irkutsk Regional Clinical Hospital

Shprakh V.V.

Irkutsk State Medical Academy of Postgraduate Education — branch of the Russian Medical Academy of Continuous Professional Education

Petrov S.I.

Irkutsk, Medical Academy of Postgraduate Education — Branch of Russian Medical Academy of Continuing Professional Education;
Irkutsk Regional Clinical Hospital;
Irkutsk Regional Clinical Tuberculosis Hospital

ORCID: 0000-0002-5132-5417

Mikhalevich I.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of Russian Medical Academy of Continuing Professional Education

Differentiated complex treatment of Parkinson’s disease considering atrophic changes of the brain

Authors:

Chipizubov V.A., Shprakh V.V., Petrov S.I., Mikhalevich I.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3): 39‑43

DOI: 10.17116/jnevro202112103139

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To cite this article:

Chipizubov VA, Shprakh VV, Petrov SI, Mikhalevich IM. Differentiated complex treatment of Parkinson’s disease considering atrophic changes of the brain. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3):39‑43. (In Russ.)
https://doi.org/10.17116/jnevro202112103139

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To develop and implement the tactics of the differentiated complex (medication in combination with surgery) treatment of the form of Parkinson’s disease (PD) associated with dyskinesias, according to the severity of atrophic changes in the brain.

MATERIAL AND METHODS

The study included 40 patients with PD associated with dyskinesias and motor fluctuations. Patients of the main group received medication and surgical treatment, patients of the comparison group received only medication. The patient’s health was assessed every 3 months during 1.5 years. Three atrophy indices were proposed to describe atrophic changes in the brain.

RESULTS

We have determined the values of the indices when the complex treatment was optimal for patients.

CONCLUSION

The results of the study are supposed to be used in the practice of neurologists and neurosurgeons.

Keywords:

Parkinson’s disease

atrophy of the brain

stereotaxic destruction of the basal nuclei

atrophy index

Authors:

Chipizubov V.A.

Irkutsk Regional Clinical Hospital

Shprakh V.V.

Irkutsk State Medical Academy of Postgraduate Education — branch of the Russian Medical Academy of Continuous Professional Education

Petrov S.I.

ORCID: 0000-0002-5132-5417

Mikhalevich I.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of Russian Medical Academy of Continuing Professional Education

Received:

07.05.2020

Accepted:

31.05.2020

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References:

Levin OS, Artemyev DV, Bril EV, Kulua TK. Parkinson’s disease: modern approaches to diagnosis and treatment. Prakticheskaya meditsina. 2017;(1):45-51. (In Russ.).
Bykov YN, Bender TB. Mobile computer technologies in personified therapy of Parkinson’s disease patients. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2018;3(1):60-65. (In Russ.). https://doi.org/10.29413/ABS.2018-3.1.9
Gibb W, Lees A. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1988;51(6):745-752. https://doi.org/10.1136/jnnp.51.6.745
Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181-184. https://doi.org/10.1136/jnnp.55.3.181
Hoehn M, Yahr M. Parkinsonism: onset, progression and mortality. Neurology. 1967;17(5):427-442. https://doi.org/10.1212/wnl.17.5.427
Goetz CG, Fahn S, Martinez-Martin P, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Mov Disord. 2007;22(1):41-47. https://doi.org/10.1002/mds.21198
Jenkinson C, Fitzpatrick R, Peto V, et al. The Parkinson’s Disease Questionnaire (PDQ-39): development and validation of a Parkinson’s disease summary index score. Age Ageing. 1997;26(5):353-357. https://doi.org/10.1093/ageing/26.5.353
Beck AT, Ward CH, Mendelson M, et al. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-571. https://doi.org/10.1001/archpsyc.1961.01710120031004