Differentiated complex treatment of Parkinson’s disease considering atrophic changes of the brain

Chipizubov V.A.; Shprakh V.V.; Petrov S.I.; Mikhalevich I.M.

doi:https://doi.org/10.17116/jnevro202112103139

Chipizubov V.A.

Irkutsk Regional Clinical Hospital

Shprakh V.V.

Irkutsk State Medical Academy of Postgraduate Education — branch of the Russian Medical Academy of Continuous Professional Education

Petrov S.I.

Irkutsk, Medical Academy of Postgraduate Education — Branch of Russian Medical Academy of Continuing Professional Education;
Irkutsk Regional Clinical Hospital;
Irkutsk Regional Clinical Tuberculosis Hospital

ORCID: 0000-0002-5132-5417

Mikhalevich I.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of Russian Medical Academy of Continuing Professional Education

Differentiated complex treatment of Parkinson’s disease considering atrophic changes of the brain

Authors:

Chipizubov V.A., Shprakh V.V., Petrov S.I., Mikhalevich I.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3): 39‑43

DOI: 10.17116/jnevro202112103139

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To cite this article:

Chipizubov VA, Shprakh VV, Petrov SI, Mikhalevich IM. Differentiated complex treatment of Parkinson’s disease considering atrophic changes of the brain. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3):39‑43. (In Russ.)
https://doi.org/10.17116/jnevro202112103139

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To develop and implement the tactics of the differentiated complex (medication in combination with surgery) treatment of the form of Parkinson’s disease (PD) associated with dyskinesias, according to the severity of atrophic changes in the brain.

MATERIAL AND METHODS

The study included 40 patients with PD associated with dyskinesias and motor fluctuations. Patients of the main group received medication and surgical treatment, patients of the comparison group received only medication. The patient’s health was assessed every 3 months during 1.5 years. Three atrophy indices were proposed to describe atrophic changes in the brain.

RESULTS

We have determined the values of the indices when the complex treatment was optimal for patients.

CONCLUSION

The results of the study are supposed to be used in the practice of neurologists and neurosurgeons.

Keywords:

Parkinson’s disease

atrophy of the brain

stereotaxic destruction of the basal nuclei

atrophy index

Authors:

Chipizubov V.A.

Irkutsk Regional Clinical Hospital

Shprakh V.V.

Irkutsk State Medical Academy of Postgraduate Education — branch of the Russian Medical Academy of Continuous Professional Education

Petrov S.I.

ORCID: 0000-0002-5132-5417

Mikhalevich I.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of Russian Medical Academy of Continuing Professional Education

Received:

07.05.2020

Accepted:

31.05.2020

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References:

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