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Murkamilov I.T.

I.K. Akhunbaev Kyrgyz State Medical Academy;
Kyrgyz-Russian Slavic University named after the First President of Russian Federation B.N. Yeltsin

Sabirov I.S.

Kyrgyz-Russian Slavic University named after the First President of Russian Federation B.N. Yeltsin

Fomin V.V.

Sechenov University

Kudaibergenova I.O.

Kyrgyz State Medical Academy named after I.K. Akhunbaev

Yusupov F.A.

Osh State University

Schastlivenko A.I.

Vitebsk State Order of Peoples Friendship Medical University

Murkamilova Zh.A.

Kyrgyz-Russian Slavic University

Cerebrovascular complications in patients with malignant neoplasms

Authors:

Murkamilov I.T., Sabirov I.S., Fomin V.V., Kudaibergenova I.O., Yusupov F.A., Schastlivenko A.I., Murkamilova Zh.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(12): 128‑133

DOI: 10.17116/jnevro2021121121128

Read: 4104 times

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Table of contents

CEREBROVASCULAR COMPLICATIONS IN PATIENTS WITH MALIGNANT NEOPLASMS
CEREBROVASCULAR COMPLICATIONS IN PATIENTS WITH MALIGNANT NEOPLASMS

To cite this article:

Murkamilov IT, Sabirov IS, Fomin VV, Kudaibergenova IO, Yusupov FA, Schastlivenko AI, Murkamilova ZhA. Cerebrovascular complications in patients with malignant neoplasms. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(12):128‑133. (In Russ.)
https://doi.org/10.17116/jnevro2021121121128

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Patients with malignant neoplasms have an increased risk of cerebrovascular complications (intratumoral hemorrhage, invasion of arterial and venous sinus by tumor mass or leptomeningeal infiltrates, and tumor embolism). The review discusses the role and importance of cisplatin and radiation therapy in the occurrence of cerebrovascular complications in patients with malignant neoplasms that may occur before, during or years after treatment. Descriptions of individual clinical observations of the lesions of the central nervous system in the treatment of cancer are provided. The type and mechanism of stroke, as well as the stage and pathology of the neoplasm, dictate the use of a multidisciplinary approach, which ensures proper management and helps to outline the prognosis in this category of patients.

Keywords:

stroke
endothelium
malignant neoplasms
cisplatin
radiation therapy

Authors:

Murkamilov I.T.

I.K. Akhunbaev Kyrgyz State Medical Academy;
Kyrgyz-Russian Slavic University named after the First President of Russian Federation B.N. Yeltsin

Sabirov I.S.

Kyrgyz-Russian Slavic University named after the First President of Russian Federation B.N. Yeltsin

Fomin V.V.

Sechenov University

Kudaibergenova I.O.

Kyrgyz State Medical Academy named after I.K. Akhunbaev

Yusupov F.A.

Osh State University

Schastlivenko A.I.

Vitebsk State Order of Peoples Friendship Medical University

Murkamilova Zh.A.

Kyrgyz-Russian Slavic University

Received:

28.05.2020

Accepted:

02.06.2020

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References:

  1. Dardiotis E, Aloizou AM, Markoula S, Siokas V, Tsarouhas K, Tzanakakis G, Gozes I. Cancer-associated stroke: Pathophysiology, detection and management. International Journal of Oncology. 2019;54:3:779-796.  https://doi.org/10.3892/ijo.2019.4669
  2. Bang OY, Chung JW, Lee MJ, Seo WK, Kim GM, Ahn MJ, & OASIS-Cancer Study Investigators. Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms. Journal of Stroke. 2020;22:1:1-10.  https://doi.org/10.5853/jos.2019.02278
  3. Graus F, Rogers LR, Posner JB: Cerebrovascular complications in patients with cancer. Medicine (Baltimore).1985;64:16-35. 
  4. Nieblas‐Bedolla E, Nayyar N, Singh M, Sullivan RJ, Brastianos PK. Emerging Immunotherapies in the Treatment of Brain Metastases. The Oncologist. 2021;26:3:231-241.  https://doi.org/10.1002/onco.13575
  5. Stefan O, Vera N, Otto B, Heinz L and Wolfgang G: Stroke in cancer patients: A risk factor analysis. J Neurooncol. 2009;94:221-226.  https://doi.org/10.1007/s11060-009-9818-3
  6. Zöller BJiJ, Sundquist J, Sundquist K. Risk of haemorrhagic and ischaemic stroke in patients with cancer: A nationwide follow-up study from Sweden. Eur J Cancer. 2012;48:1875-1883.
  7. Kitano T, Sasaki T, Gon Y, Todo K, Okazaki S, Kitamura T, Hattori S. The effect of chemotherapy on stroke risk in cancer patients. Thrombosis and Haemostasis. 2020;120:04:714-723.  https://doi.org/10.1055/s-0040-1708484
  8. Gusev EI, Martynov MYu, Kamchatnov PR, Yasamanova AN, Shchukin IA, Kolesnikova TI. Cerebral stroke. Consilium Medicum. 2014;16(12):13-17. (In Russ.).
  9. Evzelman MA, Mityaeva EV, Lashkhiia IB, Kamchatnov PR. Acute cerebral ischemia and inflammation. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2019;12-2(119):73-80. (In Russ.). https://doi.org/10.17116/jnevro201911912273
  10. Damulin IV, Ekusheva EV. Stroke and neuroplasticity. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2014;114(12):136-142. (In Russ.). https://doi.org/10.17116/jnevro2014114121136-142
  11. Kim SG, Hong JM, Kim HY, Lee J, Chung PW, Park KY, Kim GM, Lee KH, Chung CS, Bang OY. Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea. Stroke. 2010;41(4):798-801.  https://doi.org/10.1161/STROKEAHA.109.571356
  12. Sanossian N, Djabiras C, Mack WJ, Ovbiagele B. Trends in cancer diagnoses among inpatients hospitalized with stroke. J Stroke Cerebrovasc Dis. 2013;22(7):1146-1150. https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.11.016
  13. Kim SJ, Park JH, Lee MJ, Park YG, Ahn MJ, Bang OY. Clues to occult cancer in patients with ischemic stroke. PLoS One. 2012;7(9):e44959. https://doi.org/10.1371/journal.pone.0044959
  14. Cocho D, Gendre J, Boltes A, Espinosa J, Ricciardi AC, Pons J, Jimenez M, Otermin P. Predictors of occult cancer in acute ischemic stroke patients. J Stroke Cerebrovasc Dis. 2015;24(6):1324-1328. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.02.006
  15. Selvik HA, Thomassen L, Bjerkreim AT, Næss H. Cancer associated stroke: the Bergen NORSTROKE study. Cerebrovasc Dis Extra. 2015;5:107-113.  https://doi.org/10.1159/000440730
  16. Uemura J, Kimura K, Sibazaki K, Inoue T, Iguchi Y, Yamashita S. Acute stroke patients have occult malignancy more often than expected. Eur Neurol. 2010;64:140-144.  https://doi.org/10.1159/000316764
  17. Navi BB, Reiner AS, Kamel H, Iadecola C, Elkind MS, Panageas KS, DeAngelis LM. Association between incident cancer and subsequent stroke. Annals of Neurology. 2015;77:2:291-300.  https://doi.org/10.1002/ana.24325
  18. ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the esc committee for practice guidelines. Russian Journal of Cardiology. 2017;(3):105-139. (In Russ.). https://doi.org/10.15829/1560-4071-2017-3-105-139
  19. Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. Journal of Biology. 2006;5:7:22.  https://doi.org/10.1186/jbiol50
  20. Zamorano JL, Lancellotti P, Rodriguez Muñoz D, Aboyans V, Asteggiano R, Galderisi M, Lopez Fernandez T. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). European Heart Journal. 2016;37:36:2768-2801. https://doi.org/10.1093/eurheartj/ehw211
  21. Herrmann J, Yang EH, Iliescu CA, Cilingiroglu M, Charitakis K, Hakeem A, Marmagkiolis K.Vascular toxicities of cancer therapies: the old and the new—an evolving avenue. Circulation. 2016;133:13:1272-1289. https://doi.org/10.1161/CIRCULATIONAHA.115.018347
  22. Sambasivaiah K, Reddy S, Kumar BP, Suneetha P. Cisplatin induced acute cerebral infarct. Indian Journal of Medical and Paediatric Oncology. 2008;29:4:45. 
  23. Brouha ME, Bloemendal HJ, Kappelle LJ, Winter JB Cerebral infarction and myocardial infarction due to cisplatin-containingchemotherapy. Ned Tijdschr Geneeskd. 2003;147(10):457-460. 
  24. Taher A, Shamsseddine A, Saghir N, Seoud M, Mourad F, Dabajah B, Khalil A. Acquired protein C deficiency following cisplatinum-navelbine administration for locally advanced breast cancer. Case report. Eur J Gynaecol Oncol. 1999;20(4):323-324. 
  25. Licciardello JT, Moake JL, Rudy CK, Karp DD, Hong WK. Elevated plasma von Willebrand factor levels and arterial occlusive complications associated with cisplatin-based chemotherapy. Oncology. 1985;42(5):296-300.  https://doi.org/10.1159/000226049
  26. Thawabeh AN, Alghamdi NM, Bodoor AA. Cisplatin induced mesenteric ischemia. World Family. 2020;18(1):163-168.  https://doi.org/10.5742/MEWFM.2020.93742
  27. Navi BB, Reiner AS, Kamel H, Iadecola C, Okin PM, Tagawa ST, Panageas KS, DeAngelis LM. Arterial thromboembolic events preceding the diagnosis of cancer in older persons. Blood. 2019;133(8):781-789.  https://doi.org/10.1182/blood-2018-06-860874.
  28. Webb K, Prakash V, Kirresh O, Stewart A. A case of aortitis during cisplatin-based chemotherapy for cervical cancer. BJR Case Reports. 2019;5:1:20180054. https://doi.org/10.1259/bjrcr.20180054
  29. Schmorl P, Heer-Sonderhoff A, Vosshenrich R, Conrad S. Cerebral vasculitis associated with gemcitabine. Urologe A. 2010;49:268-270.  https://doi.org/10.1007/s00120-009-2203-1
  30. Läubli H, Hench J, Stanczak M, Heijnen I, Papachristofilou A, Frank S, Stenner-Liewen F. Cerebral vasculitis mimicking intracranial metastatic progression of lung cancer during PD-1 blockade. Journal for Immunotherapy of Cancer. 2017;5:1:46.  https://doi.org/10.1186/s40425-017-0249-y
  31. Babichev AV. Rol’ endoteliia v mekhanizmakh gemostaza.The role of the endothelium in the mechanisms of hemostasis. Pediatr. 2013;4(1):122-127. (In Russ.).
  32. Ma F, Sun P, Zhang X, Hamblin MH, Yin KJ. Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke. Science Signaling. 2020;13:626. pii: eaay5686. https://doi.org/10.1126/scisignal.aay5686.
  33. Toya T, Sara JD, Corban MT, Taher R, Godo S, Herrmann J, Lerman A. Assessment of peripheral endothelial function predicts future risk of solid-tumor cancer. European Journal of Preventive Cardiology. 2020;27:6:608-618.  https://doi.org/10.1177/2047487319884246
  34. Antropova IP. Hemostasis in orthopedic surgery: the role of vascular endothelium. Thrombosis Hemostasis and Rheology. 2018;2:5-11. (In Russ.).
  35. Shin YW, Lee ST, Jung KH, Kim DY, Park CK, Kim TM, Choi SH, Chu K, Lee SK. Predictors of survival for patients with cancer after cryptogenic stroke. J Neurooncol. 2016;128(2):277-284.  https://doi.org/10.1007/s11060-016-2106-0
  36. Aliyeva SB, Romanov IS, Podvyaznikov SO, Zaderenko IA, Tjulandin SA. Efficiency of induction chemotherapy with docetaxel, cisplatin and 5-fluoruracil followed by concurrent chemoradiotherapy in the treatment of stage III—IV pharyngeal and oral cancer. Head and Neck Tumors. 2011;2:14-20. (In Russ.).
  37. Akbar S, Subhan F, Shahid M, Wadood A, Shahbaz N, Farooq U, Raziq N. 6-Methoxyflavanone abates cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: A behavioral and molecular simulation study. European Journal of Pharmacology. 2020;872:172972. https://doi.org/10.1016/j.ejphar.2020.172972
  38. Meattini I, Scotti V, Pescini F, Livi L, Sulprizio S, Palumbo V, Biti G. Ischemic stroke during cisplatin-based chemotherapy for testicular germ cell tumor: case report and review of the literature. Journal of Chemotherapy. 2010;22:2:134-136.  https://doi.org/10.1179/joc.2010.22.2.134
  39. Etgen T, Weidenhöfer G, Kubin T. Cisplatin-associated occlusion of the internal carotid artery. Oncology Research and Treatment. 2009;32:12:754-757.  https://doi.org/10.1159/000252798
  40. Li SH, Chen WH, Tang Y, Rau KM, Chen YY, Huang TL, Huang CH. Incidence of ischemic stroke post-chemotherapy: a retrospective review of 10,963 patients. Clinical Neurology and Neurosurgery. 2006;108:2:150-156.  https://doi.org/10.1016/j.clineuro.2005.03.008
  41. Santos AJ, Malheiros SM, Borges LR, Dzik C, Nalli DG, Gabbai AA. Ischemic stroke after chemotherapy with cisplatin, etoposide and bleomycin: case report. Arquivos de Neuro-Psiquiatria. 2003;61:1:129-133.  https://doi.org/10.1590/s0004-282x2003000100027
  42. Khadjooi K, Adab N, Kenton A. Acute stroke secondary to carotid artery dissection in a patient with germ cell tumour: did cisplatin play a role? Oncology Research and Treatment. 2013;36:1:46-48.  https://doi.org/10.1159/000346676
  43. Sambasivaiah K, Reddy S, Kumar BP, Suneetha P. Cisplatin induced acute cerebral infarct. Indian Journal of Medical and Paediatric Oncology. 2008;29:4:45. 
  44. Jiao Y, Cao Y, Lu X, Wang J, Saitgareeva A, Kong X, Bai M. Xanthohumol protects neuron from cerebral ischemia injury in experimental stroke. Molecular Biology Reports. 2020;1-9:417-2425. https://doi.org/10.1007/s11033-019-05128-4
  45. Bai X, Tan TY, Li YX, Li Y, Chen YF, Ma R, Liu ZQ. The protective effect of cordyceps sinensis extract on cerebral ischemic injury via modulating the mitochondrial respiratory chain and inhibiting the mitochondrial apoptotic pathway. Biomedicine & Pharmacotherapy. 2020;124:109834. https://doi.org/10.1016/j.biopha.2020.109834
  46. Desai R, Desai A, Abbas SA, Patel U, Bansod S, Damarlapally N, Kumar G. National prevalence, trends and outcomes of takotsubo syndrome in hospitalizations with prior history of mediastinal/intrathoracic cancer and radiation therapy. International Journal of Cardiology. 2020;15:309:14-18.  https://doi.org/10.1016/j.ijcard.2020.02.036
  47. Murata K, Murata N, Chu B, Watase H, Hippe DS, Balu N, CARE-II Study Collaborators. Characterization of Carotid Atherosclerotic Plaques Using 3-Dimensional MERGE Magnetic Resonance Imaging and Correlation With Stroke Risk Factors. Stroke. 2020;34:45-49  https://doi.org/10.1161/STROKEAHA.119.027779
  48. Kline-Quiroz C, Nori P, Stubblefield MD. Cancer Rehabilitation: Acute and Chronic Issues, Nerve Injury, Radiation Sequelae, Surgical and Chemo-Related, Part 1. Medical Clinics. 2020;104:2:239-250.  https://doi.org/10.1016/j.mcna.2019.10.004
  49. Meshkova EM, Tomilova IK, Abramova IV, Kislyakova TV. The peculiarities of catecholamines metabolism in brain and liver of fetus and newborn in rats which developed under conditions of uteroplacental circulation disorder. Bulletin of the Ivanovo Medical Academy. 2015;20:1:18-22. (In Russ.).
  50. Kruk J, Kotarska K, Aboul-Enein BH. Physical exercise and catecholamines response: benefits and health risk: possible mechanisms. Free Radical Research. 2020;54:2-3:105-125.  https://doi.org/10.1080/10715762.2020.1726343
  51. Texakalidis P, Giannopoulos S, Tsouknidas I, Song S, Rivet DJ, Reiter ER, Reavey‐Cantwell J. Prevalence of carotid stenosis following radiotherapy for head and neck cancer: A systematic review and meta‐analysis. Head & Neck. 2020;8:56-61.  https://doi.org/10.1002/hed.26102
  52. Mueller S, Kline CN, Buerki RA, Chen Y, Yasui Y, Howell R, Fullerton HJ. Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study. Cancer. 2020;126:5:1051-1059.
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