Disease-free survival after surgical and combined treatment of newly diagnosed craniopharyngiomas in adults

Kutin MA, Kalinin PL, Golanov AV, et al. . Disease-free survival after surgical and combined treatment of newly diagnosed craniopharyngiomas in adults. Burdenko's Journal of Neurosurgery. 2024;88(5):54‑59. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20248805154

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To clarify disease-free survival in adults with newly diagnosed CP depending on resection quality; to evaluate the effectiveness of stereotactic irradiation and treatment depending on histological characteristics of tumor.

MATERIAL AND METHODS

We analyzed treatment outcomes in 398 adults over 10-year follow-up. Stereotactic irradiation was performed in 11.6% of patients. The follow-up data were obtained in 68.1% of patients. We compared 5-year disease-free survival rates after different resections with and without subsequent irradiation.

RESULTS

Total resection is effective and provides significantly lower risk of CP recurrence. Effectiveness of stereotactic irradiation after incomplete resection was also confirmed.

CONCLUSION

Total resection of ACP and PCP provides high disease-free survival rates. Stereotactic irradiation after incomplete resection is followed by similar outcomes. PCPs are characterized by less aggressive growth and do not recur after total resection.

Keywords:

craniopharyngioma

chiasmal-sellar region

neurosurgery

recurrence

radiotherapy

Authors:

Kutin M.A.

Burdenko Neurosurgical Center;
Russian Biotechnology University

ORCID: 0000-0002-6520-4296

Kalinin P.L.

Burdenko Neurosurgical Center

ORCID: 0000-0001-9333-9473

Golanov A.V.

Burdenko Neurosurgical Center;
Russian Medical Academy for Continuous Professional Education

ORCID: 0000-0002-0976-4547

Fomichev D.V.

Burdenko Neurosurgical Center

ORCID: 0000-0002-5323-1000

Trunin Yu.Yu.

Burdenko Neurosurgical Center

ORCID: 0000-0002-4240-5036

Savateev A.N.

Research Institute of Emergency Pediatric Surgery and Traumatology

SPIN RSCI: 4505-7703
Scopus AuthorID: 57194756068
ORCID: 0000-0001-6433-1202

Strunina Yu.V.

Burdenko Neurosurgical Center

ORCID: 0000-0003-1696-4050

Klochkova I.S.

Burdenko Neurosurgical Center

ORCID: 0000-0002-7440-4687

Ivanov V.V.

Burdenko Neurosurgical Center;
Lomonosov Moscow State University

ORCID: 0000-0003-3827-8676

Konovalov A.N.

Burdenko Neurosurgical Center

ORCID: 0000-0002-1731-6568

Received:

19.03.2024

Accepted:

21.06.2024

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