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Khoreva M.A.

Altai State Medical University

Postcovid syndrome — a new reality

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Khoreva M.A.

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Khoreva MA. Postcovid syndrome — a new reality. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10):131‑137. (In Russ.)
https://doi.org/10.17116/jnevro2021121101131

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References:

  1. Yassin A, Nawaiseh M, Shaban A, Alsherbini K, El-Salem K, Soudah O, Abu-Rub M. Neurological manifestations and complications of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. BMC Neurology. 2021;21(1):138.  https://doi.org/10.1186/s12883-021-02161-4
  2. Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, Cook JR, Nordvig AS, Shalev D, Sehrawat TS, Ahluwalia N, Bikdeli B, Dietz D, Der-Nigoghossian C, Liyanage-Don N, Rosner GF, Bernstein EJ, Mohan S, Beckley AA, Seres DS, Choueiri TK, Uriel N, Ausiello JC, Accili D, Freedberg DE, Baldwin M, Schwartz A, Brodie D, Garcia CK, Elkind MSV, Connors JM, Bilezikian JP, Landry DW, Wan EY. Post-acute COVID-19 syndrome. Nature Medicine. 2021;27(4):601-615.  https://doi.org/10.1038/s41591-021-01283-z
  3. Goërtz YMJ, Van Herck M, Delbressine JM, Vaes AW, Meys R, Machado FVC, Houben-Wilke S, Burtin C, Posthuma R, Franssen FME, van Loon N, Hajian B, Spies Y, Vijlbrief H, van ‘t Hul AJ, Janssen DJA, Spruit MA. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Research. 2020;6(4):00542-2020. https://doi.org/10.1183/23120541.00542-2020
  4. Akbarialiabad H, Taghrir MH, Abdollahi A, Ghahramani N, Kumar M, Paydar S, Razani B, Mwangi J, Asadi-Pooya AA, Malekmakan L, Bastani B. Long COVID, a comprehensive systematic scoping review. Infection. 2021;28:1-24.  https://doi.org/10.1007/s15010-021-01666-x
  5. Sigfrid L, Drake TM, Pauley E, Jesudason EC, Olliaro P, Lim WS, Gillesen A, Berry C, Lowe DJ, McPeake J, Lone N, Munblit D, Cevik M, Casey A, Bannister P, Russell CD, Goodwin L, Ho A, Turtle L, O’Hara ME, Hastie C, Donohue C, Spencer RG, Donegan C, Gummery A, Harrison J, Hardwick HE, Hastie CE, Carson G, Merson L, Baillie JK, Openshaw P, Harrison EM, Docherty AB, Semple MG, Scott JT; ISARIC4C investigators. Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. The Lancet Regional Health — Europe. 2021;8:100186. https://doi.org/10.1016/j.lanepe.2021.100186
  6. Carfì A, Bernabei R, Landi F; Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020;324(6):603-605.  https://doi.org/10.1001/jama.2020.12603
  7. Al-Aly Z, Xie Y, Bowe B. High-dimensional characterization of post-acute sequelae of COVID-19. Nature. 2021;594(7862):259-264.  https://doi.org/10.1038/s41586-021-03553-9
  8. Chou SH, Beghi E, Helbok R, Moro E, Sampson J, Altamirano V, Mainali S, Bassetti C, Suarez JI, McNett M; GCS-NeuroCOVID Consortium and ENERGY Consortium. Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium. JAMA Network Open. 2021;4(5):e2112131. https://doi.org/10.1001/jamanetworkopen.2021.12131
  9. Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C, Fafi-Kremer S, Ohana M, Anheim M, Meziani F. Neurologic Features in Severe SARS-CoV-2 Infection. New England Journal of Medicine. 2020;382(23):2268-2270. https://doi.org/10.1056/NEJMc2008597
  10. Rogers JP, Chesney E, Oliver D, Pollak TA, McGuire P, Fusar-Poli P, Zandi MS, Lewis G, David AS. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry. 2020;7(7):611-627.  https://doi.org/10.1016/S2215-0366(20)30203-0
  11. Zhou H, Lu S, Chen J, Wei N, Wang D, Lyu H, Shi C, Hu S. The landscape of cognitive function in recovered COVID-19 patients. Journal of Psychiatric Research. 2020;129:98-102.  https://doi.org/10.1016/j.jpsychires.2020.06.022
  12. Ali Awan H, Najmuddin Diwan M, Aamir A, Ali M, Di Giannantonio M, Ullah I, Shoib S, De Berardis D. SARS-CoV-2 and the Brain: What Do We Know about the Causality of ‘Cognitive COVID? Journal of Clinical Medicine. 2021;10(15):3441. https://doi.org/10.3390/jcm10153441
  13. Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, Cook JR, Nordvig AS, Shalev D, Sehrawat TS, Ahluwalia N, Bikdeli B, Dietz D, Der-Nigoghossian C, Liyanage-Don N, Rosner GF, Bernstein EJ, Mohan S, Beckley AA, Seres DS, Choueiri TK, Uriel N, Ausiello JC, Accili D, Freedberg DE, Baldwin M, Schwartz A, Brodie D, Garcia CK, Elkind MSV, Connors JM, Bilezikian JP, Landry DW, Wan EY. Post-acute COVID-19 syndrome. Nature Medicine. 2021;27(4):601-615.  https://doi.org/10.1038/s41591-021-01283-z
  14. Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry. 2021;8(5):416-427.  https://doi.org/10.1016/S2215-0366(21)00084-5
  15. Jaywant A, Vanderlind WM, Alexopoulos GS, Fridman CB, Perlis RH, Gunning FM. Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19. Neuropsychopharmacology. 2021;15:1-6.  https://doi.org/10.1038/s41386-021-00978-8
  16. Hampshire A, Trender W, Chamberlain S, Jolly A, Grant J, Patrick F, Mazibuko N, Williams S, Barnby J, Hellyer P, Mehta M. Cognitive deficits in people who have recovered from COVID-19. E Clinical Medicine. 2021;101044. https://doi.org/10.1016/j.eclinm.2021.101044
  17. Woo MS, Malsy J, Pöttgen J, Seddiq Zai S, Ufer F, Hadjilaou A, Schmiedel S, Addo MM, Gerloff C, Heesen C, Schulze Zur Wiesch J, Friese MA. Frequent neurocognitive deficits after recovery from mild COVID-19. Brain Communications. 2020;2(2):fcaa205. https://doi.org/10.1093/braincomms/fcaa205
  18. Dubey S, Biswas P, Ghosh R, Chatterjee S, Dubey MJ, Chatterjee S, Lahiri D, Lavie CJ. Psychosocial impact of COVID-19. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14(5):779-788.  https://doi.org/10.1016/j.dsx.2020.05.035
  19. Mosolov SN. Problemy psihicheskogo zdorov’ya v usloviyah pandemii COVID-19. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2020;120(5):7-15. (In Russ.). https://doi.org/10.17116/jnevro20201200517
  20. Cagnin A, Di Lorenzo R, Marra C, Bonanni L, Cupidi C, Laganà V, Rubino E, Vacca A, Provero P, Isella V, Vanacore N, Agosta F, Appollonio I, Caffarra P, Pettenuzzo I, Sambati R, Quaranta D, Guglielmi V, Logroscino G, Filippi M, Tedeschi G, Ferrarese C, Rainero I, Bruni AC; SINdem COVID-19 Study Group. Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia. Frontiers in Psychiatry. 2020;11:578015. https://doi.org/10.3389/fpsyt.2020.578015
  21. Cohen G, Russo MJ, Campos JA, Allegri RF. COVID-19 Epidemic in Argentina: Worsening of Behavioral Symptoms in Elderly Subjects With Dementia Living in the Community. Frontiers in Psychiatry. 2020;11:866.  https://doi.org/10.3389/fpsyt.2020.00866
  22. Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-446.  https://doi.org/10.1016/S0140-6736(20)30367-6
  23. Brown EE, Kumar S, Rajji TK, Pollock BG, Mulsant BH. Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer’s Disease and Related Dementias. The American Journal of Geriatric Psychiatry. 2020;28(7):712-721.  https://doi.org/10.1016/j.jagp.2020.04.010
  24. Ritchie K, Chan D, Watermeyer T. The cognitive consequences of the COVID-19 epidemic: collateral damage? Brain Communications. 2020;2(2):fcaa069. https://doi.org/10.1093/braincomms/fcaa069
  25. Cagnin A, Di Lorenzo R, Marra C, Bonanni L, Cupidi C, Laganà V, Rubino E, Vacca A, Provero P, Isella V, Vanacore N, Agosta F, Appollonio I, Caffarra P, Pettenuzzo I, Sambati R, Quaranta D, Guglielmi V, Logroscino G, Filippi M, Tedeschi G, Ferrarese C, Rainero I, Bruni AC; SINdem COVID-19 Study Group. Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia. Frontiers in Psychiatry. 2020;11:578015. https://doi.org/10.3389/fpsyt.2020.578015
  26. Ramani A, Müller L, Ostermann PN, Gabriel E, Abida-Islam P, Müller-Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey A, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan J. SARS-CoV-2 targets neurons of 3D human brain organoids. The EMBO Journal. 2020;39(20):e106230. https://doi.org/10.15252/embj.2020106230
  27. Chekol Abebe E, Mengie Ayele T, Tilahun Muche Z, Asmamaw Dejenie T. Neuropilin 1: A Novel Entry Factor for SARS-CoV-2 Infection and a Potential Therapeutic Target. Biologics. 2021;15:143-152.  https://doi.org/10.2147/BTT.S307352
  28. Erickson MA, Rhea EM, Knopp RC, Banks WA. Interactions of SARS-CoV-2 with the Blood — Brain Barrier. International Journal of Molecular Sciences. 2021;22(5):2681. https://doi.org/10.3390/ijms22052681
  29. Jha NK, Ojha S, Jha SK, Dureja H, Singh SK, Shukla SD, Chellappan DK, Gupta G, Bhardwaj S, Kumar N, Jeyaraman M, Jain R, Muthu S, Kar R, Kumar D, Goswami VK, Ruokolainen J, Kesari KK, Singh SK, Dua K. Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System: A Review on Neurological Impairments and Manifestations. Journal of Molecular Neuroscience. 2021;19:1-18.  https://doi.org/10.1007/s12031-020-01767-6
  30. Al-Ramadan A, Rabab’h O, Shah J, Gharaibeh A. Acute and Post-Acute Neurological Complications of COVID-19. Neurology International. 2021;13(1):102-119.  https://doi.org/10.3390/neurolint13010010
  31. Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal of Experimental Medicine. 2021;218(3):e20202135. https://doi.org/10.1084/jem.20202135
  32. Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A. SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration. Movement Disorders. 2020;35(5):716-720.  https://doi.org/10.1002/mds.28084
  33. Lu Y, Li X, Geng D, Mei N, Wu PY, Huang CC, Jia T, Zhao Y, Wang D, Xiao A, Yin B. Cerebral Micro-Structural Changes in COVID-19 Patients — An MRI-based 3-month Follow-up Study. E Clinical Medicine. 2020;25:100484. https://doi.org/10.1016/j.eclinm.2020.100484
  34. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. Journal of Medical Virology. 2020;92(6):552-555.  https://doi.org/10.1002/jmv.25728
  35. Yong SJ. Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis. ACS Chemical Neuroscience. 2021;12(4):573-580.  https://doi.org/10.1021/acschemneuro.0c00793
  36. Mukaetova-Ladinska EB, Kronenberg G, Raha-Chowdhury R. COVID-19 and neurocognitive disorders. Current Opinion in Psychiatry. 2021;34(2):149-156.  https://doi.org/10.1097/YCO.0000000000000687
  37. Lahiri D, Ardila A. COVID-19 Pandemic: A Neurological Perspective. Cureus. 2020;12(4):e7889. https://doi.org/10.7759/cureus.7889
  38. Beishon L, Panerai RB. The Neurovascular Unit in Dementia: An Opinion on Current Research and Future Directions. Frontiers in Aging Neuroscience. 2021;13:721937. https://doi.org/10.3389/fnagi.2021.721937
  39. Miners S, Kehoe PG, Love S. Cognitive impact of COVID-19: looking beyond the short term. Alzheimer’s Research & Therapy. 2020;12(1):170.  https://doi.org/10.1186/s13195-020-00744-w
  40. Sasannejad C, Ely EW, Lahiri S. Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Critical Care. 2019;23(1):352.  https://doi.org/10.1186/s13054-019-2626-z
  41. Ardila A, Lahiri D. Executive dysfunction in COVID-19 patients. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14(5):1377-1378. https://doi.org/10.1016/j.dsx.2020.07.032
  42. Honarmand K, Lalli RS, Priestap F, Chen JL, McIntyre CW, Owen AM, Slessarev M. Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review. American Journal of Respiratory and Critical Care Medicine. 2020;202(2):193-201.  https://doi.org/10.1164/rccm.201904-0816CI
  43. Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, et al. Long-term cognitive impairment after critical illness. New England Journal of Medicine. 2013;369:1306-1316. https://doi.org/10.1056/NEJMoa1301372
  44. Iadecola C, Anrather J, Kamel H. Effects of COVID-19 on the nervous system. Cell. 2020;183:16-27.  https://doi.org/10.1016/j.cell.2020.08.028
  45. De Erausquin GA, Snyder H, Carrillo M, Hosseini AA, Brugha TS, Seshadri S; CNS SARS-CoV-2 Consortium. The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning. Alzheimer’s & Dementia. 2021;17(6):1056-1065. https://doi.org/10.1002/alz.12255
  46. Moghimi N, Di Napoli M, Biller J, Siegler JE, Shekhar R, McCullough LD, Harkins MS, Hong E, Alaouieh DA, Mansueto G, Divani AA. The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection. Current Neurology and Neuroscience Reports. 2021;21(9):44.  https://doi.org/10.1007/s11910-021-01130-1
  47. Gomazkov OA. Korteksin: molekulyarnye mekhanizmy i misheni nejroprotektivnoj aktivnosti. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2015;115(8):99-104. (In Russ.). https://doi.org/10.17116/jnevro20151158199-104
  48. Yakovlev AA, Lyzhin AA, Khaspekov LG, Guekht AB, Gulyaeva NV. Peptide drug cortexin inhibits brain caspase-8. Biomeditsinskaya Khimiya. 2017;63(1):27-31. 
  49. Peptidnaya nejroprotekciya. Sbornik nauchnyh statej. Pod red. D’yakonova M.M., Kamenskogo A.A. SPb.: Nauka; 2009. (In Russ.).
  50. Peptidnaya nejroprotekciya. Sbornik nauchnyh statej. Pod red. D’yakonova M.M., Kamenskogo A.A. SPb.: Nauka; 2009. (In Russ.).
  51. Yakovlev AA, Gulyaeva NV. Molekulyarnye partnery Korteksina v mozge. Nejrohimiya. 2017;33(1):91-96. (In Russ.). https://doi.org/10.7868/s1027813316040166
  52. Stepanichev MYu, Onufriev MV, Lazareva NA, Moiseeva YuV, Nesterenko AN, Novikova MR, Stefanova NA, Kolosova NG, Gulyaeva NV. Vliyanie preparata Korteksin na svobodnoradikal’noe okislenie i vospalitel’nye processy u krys s normal’nym i uskorennym stareniem. Nejrohimiya. 2018;35(2):1-12. (In Russ.). https://doi.org/10.7868/s1027813318020127
  53. Gulyaeva NV. Molekulyarnye mekhanizmy dejstviya preparatov, soderzhashchih peptidy mozga: korteksin. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2018;118(10):93-96. (In Russ.). https://doi.org/10.17116/jnevro201811810193

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