Numerous studies suggest that pregnant women are at risk for severe morbidity, adverse gestational outcomes, and mortality after SARSCoV-2 infection. The high-risk group for developing severe forms of COVID-19 is made up of patients with concomitant somatic pathologies: chronic lung diseases, diseases of the cardiovascular system, arterial hypertension, diabetes mellitus, oncological diseases, obesity, chronic kidney disease, liver disease.

STUDY AIM

To study the medical and genetic risk factors for the severe course of a new SARS-CoV-2 coronavirus infection in women during pregnancy.

MATERIALS AND METHODS

An open prospective continuous cross-sectional study in which 114 patients after suffering SARS-CoV-2 were examined, who were in the period of 2020-2021 on inpatient treatment at a maternity hospital as part of a multidisciplinary infectious diseases hospital, Moscow, Russia. Depending on the severity of the underlying disease, groups were identified: group I (n=36) — patients with mild SARS-CoV-2 coronavirus infection, group II (n=56) — women with moderate severity, group III (n=22) — patients with a severe course.

RESULTS

Risk factors for severe course of the novel coronavirus infection SARS-CoV-2 in pregnant women: age over 35 years (OR=4.7; 95% CI: 1.9—12.0), pregnancy after in vitro fertilization (OR=6.8; 95% CI: 2.2—22.7), family history of cardiovascular disease, diabetes mellitus, and bronchial asthma in first-line relatives (OR=8.5; 95% CI: 3.4—22.4), obesity (OR=31.1; 95% CI: 9.2—105.3), diseases of the circulatory system (OR=16.4; 95% CI: 5.0—54.0), diseases of the genitourinary systems (OR=4.4; 95% CI: 1.7—11.6), respiratory diseases (OR=6.8; 95% CI: 2.0—22.9), gestational diabetes mellitus (OR=8.5; 95% CI: 2.9—27.4), high-risk thrombophilia (OR=7.2; 95% CI: 2.9—19.6).