Oxidative stress and post-stroke depression

Trofimova S.A.; Balunov O.A.; Dubinina E.E.

doi:https://doi.org/10.17116/jnevro202012007144

Trofimova S.A.

BekhterevNational Research Medical Center of Psychiatry and Neurology

Balunov O.A.

BekhterevNational Research Medical Center of Psychiatry and Neurology

Dubinina E.E.

BekhterevNational Research Medical Center of Psychiatry and Neurology

Oxidative stress and post-stroke depression

Authors:

Trofimova S.A., Balunov O.A., Dubinina E.E.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(7): 44‑49

DOI: 10.17116/jnevro202012007144

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To cite this article:

Trofimova SA, Balunov OA, Dubinina EE. Oxidative stress and post-stroke depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(7):44‑49. (In Russ.)
https://doi.org/10.17116/jnevro202012007144

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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OBJECTIVE

To study the use of combination therapy for post-stroke depression using antidepressants and antioxidants.

MATERIAL AND METHODS

The dynamics of the clinical status of post-stroke depression and parameters of oxidative stress were evaluated in 60 patients with post-stroke depression before and after a 3-month treatment with fluvoxamine in a daily dose of 100 mg per day and cytoflavin in a dose of 10 ml/day (200 ml of 5% glucose solution or physiological saline in patients with diabetes mellitus) intravenously in the morning for 10 days followed by transfer to tablet form (2 tabs in the morning and 2 tabs in the evening for 90 days).

RESULTS AND CONCLUSION

The results on the comparative effectiveness of the treatment of post-stroke depression with fluvoxamine monotherapy and the combination of fluvoxamine and cytoflavin confirmed the great effectiveness of the combination therapy, which should be taken into account when developing new treatment regimens for post-stroke depression, and the need for prescribing antidepressants and antioxidant drugs should be determined based on an individual assessment of the severity of depressive disorder and parameters of oxidative stress: endogenous antioxidant activities in each individual patient with ischemic stroke.

Keywords:

stroke

depression

oxidative stress

antioxidants

cytoflavin

fluvoxamine

Authors:

Trofimova S.A.

BekhterevNational Research Medical Center of Psychiatry and Neurology

Balunov O.A.

BekhterevNational Research Medical Center of Psychiatry and Neurology

Dubinina E.E.

BekhterevNational Research Medical Center of Psychiatry and Neurology

Received:

15.04.2020

Accepted:

28.04.2020

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