Anti-NMDAR encephalitis associated with relapsing optic neuritis

Belova A.N.; Grygorieva V.N.; Rasteryaeva M.V.; Ruina E.A.; Belova E.M.; Solovieva V.S.; Boyko A.N.

doi:https://doi.org/10.17116/jnevro2020120061105

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Abstract:

Autoimmune encephalitis with antibodies to NMDA receptors (anti-NMDAR encephalitis), is the most common form of autoimmune encephalitis. The disease is curable, however, the lack of timely therapy can lead to the disability of patients or to the death. Difficulties in the diagnosis of anti-NMDAR encephalitis are caused by the heterogeneity of its manifestations, a possible overlapping with other autoimmune diseases and insufficient awareness about this form of encephalitis. This article describes the case of anti-NMDAR encephalitis associated with recurrent optic neuritis which might be an atypical manifestation for this disease. Optic neuritis could not be explained by overlapping with multiple sclerosis or neuromyelitis optica spectrum disorders.

Keywords:

anti-NMDA receptor encephalitis

optic neuritis

multiple sclerosis

neuromyelitis optica spectrum disorders

overlapping syndromes

Authors:

Belova A.N.

Privolzhsky Research Medical University

SPIN RSCI: 3084-3096
Scopus AuthorID: 7005138294
ORCID: 0000-0001-9719-6772

Grygorieva V.N.

Privolzhsky Research Medical University

SPIN RSCI: 3412-5653
Scopus AuthorID: 57213149824
ORCID: 0000-0002-6256-3429

Rasteryaeva M.V.

Privolzhsky Research Medical University

SPIN RSCI: 2516-3160
Scopus AuthorID: 55657565800
ORCID: 0000-0002-8462-3824

Ruina E.A.

Privolzhsky Research Medical University

SPIN RSCI: 1668-1763
Scopus AuthorID: 55560658800
ORCID: 0000-0003-4595-2614

Belova E.M.

City Clinical Hospital No. 3

ORCID: 0000-0002-6698-321X

Solovieva V.S.

City Clinical Hospital No. 3

Scopus AuthorID: 57200326421
ORCID: 0000-0003-3241-7145

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

SPIN RSCI: 9921-9109
Scopus AuthorID: 7102247663
ORCID: 0000-0002-2975-4151

Received:

17.09.2019

Accepted:

07.10.2019

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References:

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