Анти-NMDAR энцефалит с рецидивирующим поражением зрительных нервов

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Аутоиммунный энцефалит с антителами к NMDA-рецепторам (анти-NMDAR энцефалит) является частой формой аутоиммунных энцефалитов. Заболевание относится к разряду курабельных, однако отсутствие своевременной терапии может приводить к инвалидизации пациентов или летальному исходу. Трудности диагностики анти-NMDAR энцефалита обусловлены гетерогенностью его проявлений, возможным сочетанием с другими аутоиммунными заболеваниями и недостаточно высокой осведомленностью врачей относительно этой формы энцефалита. В статье приводится обзор данных литературы и описание случая анти-NMDAR энцефалита с нетипичными проявлениями в виде повторных оптических невритов, при этом поражение зрительных нервов трудно связать с коморбидностью с рассеянным склерозом или заболеваниями спектра оптиконейромиелита.

Ключевые слова:

анти-NMDAR энцефалит

оптический неврит

рассеянный склероз

заболевания спектра оптиконейромиелита

коморбидность

Авторы:

Белова А.Н.

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России

Григорьева В.Н.

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России

Растеряева М.В.

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России

Руина Е.А.

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России

Белова Е.М.

ГБУЗ «Городская клиническая больница №3»

Соловьева В.С.

ГБУЗ «Городская клиническая больница №3»

Бойко А.Н.

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова»; ФЦ мозга и нейротехнологий

Даты поступления:

17.09.2019

Даты принятия в печать:

07.10.2019

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