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Sumina S.V.

Federal State Budgetary Health Institution 'Saint-Petersburg clinical hospital of the Russian Academy of Sciences', St. Petersburg, Russia

Bogomolov V.V.

Federal State Budgetary Health Institution 'Saint-Petersburg clinical hospital of the Russian Academy of Sciences', St. Petersburg, Russia

Shishkin A.B.

Federal State Budgetary Health Institution 'Saint-Petersburg clinical hospital of the Russian Academy of Sciences', St. Petersburg, Russia

Suvorova Yu.V.

St. Petersburg Clinical Hospital of the Russian Academy of Sciences, St. Petersburg, Russia

Bogomolova D.V.

North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

Sergeeva T.A.

FGOU VFO «Sankt-Peterburgskij gosudarstvennyj universitet», Sankt-Peterburg, Rossija, 199034;
FGBUZ «Sankt-Peterburgskaja klinicheskaja bol'nitsa Rossijskoj akademii nauk», Sankt-Peterburg, Rossija, 194017

Merkulov M.A.

St. Petersburg University 199034, St. Petersburg, Russia

Diagnostic problems and treatment of late neurosyphilis in a young patient: a case report

Authors:

Sumina S.V., Bogomolov V.V., Shishkin A.B., Suvorova Yu.V., Bogomolova D.V., Sergeeva T.A., Merkulov M.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(2): 98‑102

DOI: 10.17116/jnevro202012002198

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Table of contents

DIAGNOSTIC PROBLEMS AND TREATMENT OF LATE NEUROSYPHILIS IN A YOUNG PATIENT: A CASE REPORT
DIAGNOSTIC PROBLEMS AND TREATMENT OF LATE NEUROSYPHILIS IN A YOUNG PATIENT: A CASE REPORT

To cite this article:

Sumina SV, Bogomolov VV, Shishkin AB, Suvorova YuV, Bogomolova DV, Sergeeva TA, Merkulov MA. Diagnostic problems and treatment of late neurosyphilis in a young patient: a case report. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(2):98‑102. (In Russ.)
https://doi.org/10.17116/jnevro202012002198

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

A clinical case of late neurosyphilis with prominent cognitive function failure developed in a young male patient is presented. Atypical disease development and negative laboratory tests required to perform the differential diagnosis with inflammatory and degenerative brain diseases, extended blood and CSF tests for syphilis. During the diagnostic procedures the patient received complex therapy with neurotropic, antioxidant, and anti-dementia drugs. The treatment improved cognitive function and increased the efficacy of further treatment.

Keywords:

late neurosyphilis
progressive paralysis
Argyll Robertson syndrome
neuropsychological testing
cytoflavinum
TPPA test
FTA-ABS

Authors:

Sumina S.V.

Federal State Budgetary Health Institution 'Saint-Petersburg clinical hospital of the Russian Academy of Sciences', St. Petersburg, Russia

Bogomolov V.V.

Federal State Budgetary Health Institution 'Saint-Petersburg clinical hospital of the Russian Academy of Sciences', St. Petersburg, Russia

Shishkin A.B.

Federal State Budgetary Health Institution 'Saint-Petersburg clinical hospital of the Russian Academy of Sciences', St. Petersburg, Russia

Suvorova Yu.V.

St. Petersburg Clinical Hospital of the Russian Academy of Sciences, St. Petersburg, Russia

Bogomolova D.V.

North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

Sergeeva T.A.

FGOU VFO «Sankt-Peterburgskij gosudarstvennyj universitet», Sankt-Peterburg, Rossija, 199034;
FGBUZ «Sankt-Peterburgskaja klinicheskaja bol'nitsa Rossijskoj akademii nauk», Sankt-Peterburg, Rossija, 194017

Merkulov M.A.

St. Petersburg University 199034, St. Petersburg, Russia

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References:

  1. Dmitriev GA Dolya OV, Vasil’eva TI. Syphilis: phenomenon, evolution, innovation. M.: Binom; 2010. (In Russ.)
  2. Chebotarev VV. Syphilis. Stavropol’. 2010. (In Russ.)
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  6. Mavlyutova GI, Yusupova LA, Misbakhova AG. Late forms of syphilis: current state of the problem. Lechashhij vrach. 2015;6:73-79. (In Russ.)
  7. Mironenko TV, Khubetova IV, Mironenko MO, Pogorelova GA. Neurosyphilis Analytical review and own observation. Mezhdunarodnyj Nevrologicheskij Zhurnal. 2014;4(66):163-169. http://cyberleninka.ru/article/n/neyrosifilis-analiticheskoe-obozrenie-i-sobstvennoe-nablyudenie/5422:16491362
  8. Potekaev NN, Loseva OK, Polyakova AA, Chistyakova AA, Lebedeva GA. Problems of identification, diagnosis and management of patients with neurosyphilis in Moscow. Klinicheskaya Dermatologiya i Venerologiya. 2012;2:48-51. (In Russ.)
  9. Federal clinical guidelines for the treatment of patients with syphilis. M. 2015. (In Russ.)
  10. Vasil’eva OA, Kubrin EA, Karpov SM, Shevchenko PP. Late neurosyphilis as a factor of cognitive impairment. Fundamental’nye issledovaniya. 2012;4(2):256-259. (In Russ.) http://fundamental-research.ru/ru/article/viewid=29801
  11. Kulagin VI, Selisskij GD, Bogush PG. The problem of syphilis of the nervous system. Vestnik dermatologii i venerologii. 2003;2:63-66. (In Russ.)
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  13. Syuch NI, Polevshhikova SA, Yakupov IA, Gal’ IG, Dulin PA. Neurosyphilis in clinical practice. Klinicheskaya Meditsina. 2014;4:51-53. (In Russ.)
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