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Putilina M.V.

Pirogov Russian National Research Medical University

Vechorko V.I.

Filatov City Clinical Hospital No.15 of the Moscow Departament of Health

Grishin D.V.

Pirogov Russian National Research Medical University;
Filatov City Clinical Hospital No. 15

Sidelnikova L.V.

Filatov Clinical Hospital

Acute cerebrovascular accidents associated with SARS-CoV-2 coronavirus infection (COVID-19)

Authors:

Putilina M.V., Vechorko V.I., Grishin D.V., Sidelnikova L.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12): 109‑117

DOI: 10.17116/jnevro2020120121109

Read: 10889 times

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Table of contents

ACUTE CEREBROVASCULAR ACCIDENTS ASSOCIATED WITH SARS-COV-2 CORONAVIRUS INFECTION (COVID-19)
ACUTE CEREBROVASCULAR ACCIDENTS ASSOCIATED WITH SARS-COV-2 CORONAVIRUS INFECTION (COVID-19)

To cite this article:

Putilina MV, Vechorko VI, Grishin DV, Sidelnikova LV. Acute cerebrovascular accidents associated with SARS-CoV-2 coronavirus infection (COVID-19). S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12):109‑117. (In Russ.)
https://doi.org/10.17116/jnevro2020120121109

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Использование инфографики авторами научных работ
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Abstract:

Acute cerebrovascular accidents (ACVIs) associated with COVID-19 coronavirus infection are one of the most talked about problems in the medical community. To date, the true incidence of stroke in patients with COVID-19 remains unclear. So far, the published literature has been limited to case reports, case series, and observational cohort studies. The article analyzes possible risk factors, especially the age of patients, pathogenetic and clinical correlations of ACVA and SARS-CoV-2 (COVID-19). A clinical case of an 82-year-old patient with ischemic stroke and COVID-19 infection is described.

Keywords:

SARS-CoV-2 coronavirus
neuroinflammation
cytokine storm
acute cerebrovascular accident
stroke
brain neurotrophic factor

Authors:

Putilina M.V.

Pirogov Russian National Research Medical University

Vechorko V.I.

Filatov City Clinical Hospital No.15 of the Moscow Departament of Health

Grishin D.V.

Pirogov Russian National Research Medical University;
Filatov City Clinical Hospital No. 15

Sidelnikova L.V.

Filatov Clinical Hospital

Received:

24.11.2020

Accepted:

26.11.2020

Close metadata

References:

  1. Li Y, Li M, Wang M, et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol. 2020;5(3):279-284.  https://doi.org/10.1136/svn-2020-000431
  2. Jin X, Lian JS, Hu JH, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-1009. https://doi.org/10.1136/gutjnl-2020-320926 PMID:32213556
  3. Liang W, Liang H, Ou L, et al. Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19. JAMA Intern Med. 2020;180(8):1081-1089. https://doi.org/10.1001/jamainternmed.2020.2033
  4. Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. https://doi.org/10.1056/NEJMoa2002032
  5. Koralnik IJ, Tyler KL. COVID-19: A Global Threat to the Nervous System. Ann Neurol. 2020;88(1):1-11.  https://doi.org/10.1002/ana.25807
  6. Pranata R, Huang I, Lim MA, et al. Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression. J Stroke Cerebrovasc Dis. 2020;29(8):104949. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104949
  7. Grau AJ, Buggle F, Becher H, et al. Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia: clinical and biochemical studies. Neurology. 1998;50(1):196-203.  https://doi.org/10.1212/wnl.50.1.196
  8. Belani P, Schefflein J, Kihira S, et al. COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke. AJNR Am J Neuroradiol. 2020;41(8):1361-1364. https://doi.org/10.3174/ajnr.A6650
  9. Naeimi R, Ghasemi-Kasman M. Update on cerebrovascular manifestations of COVID-19. Neurol Sci. 2020;41(12):3423-3435. https://doi.org/10.1007/s10072-020-04837-0
  10. Bodro M, Compta Y, Llansó L, et al. Increased CSF levels of IL-1β, IL-6, and ACE in SARS-CoV-2-associated encephalitis. Neurol Neuroimmunol Neuroinflamm. 2020;7(5):e821. https://doi.org/10.1212/NXI.0000000000000821
  11. Putilina MV, Grishin DV. SARS-CoV-2 (COVID-19) as a predictor of neuroinflammation and neurodegeneration: potential therapy strategies. S.S. Korsakov Journal of Neurology and Psychiatry (special issues) = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020;120(8):58-64. (In Russ.). https://doi.org/10.17116/jnevro202012008258]
  12. Conti P, Ronconi G, Caraffa A, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020;34(2). https://doi.org/10.23812/CONTI-E
  13. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-280.e8.  https://doi.org/10.1016/j.cell.2020.02.052
  14. Zubair AS, McAlpine LS, Gardin T, et al. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. JAMA Neurol. 2020;77(8):1018-1027. https://doi.org/10.1001/jamaneurol.2020.2065
  15. Fedin AI, Old EP, Putilin MV, et al. Endothelial dysfunction in patients with chronic cerebral ischemia and possibilities of its pharmacological correction of the. Attending Physician. 2015;(5):15-18. (In Russ.).
  16. Hampl V, Herget J, Bíbová J, Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64(1):25-38.  https://doi.org/10.33549/physiolres.932861
  17. Becker, Richard C. COVID-19 update: Covid-19-associated coagulopathy. J Thromb Thrombolysis. 2020;50(1):54-67.  https://doi.org/10.1007/s11239-020-02134-3
  18. Tan YK, Goh C, Leow AST, et al. COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature. J Thromb Thrombolysis. 2020;50(3):587-595.  https://doi.org/10.1007/s11239-020-02228-y
  19. Zhang Y, Xiao M, Zhang S, et al. Coagulopathy and antiphospholipid antibodies in patients with Covid-19. N Engl J Med. 2020;382(17):e38.  https://doi.org/10.1056/NEJMc2007575
  20. Harzallah I, Debliquis A, Drénou B. Lupus anticoagulant is frequent in patients with Covid-19. J Thromb Haemost. 2020;18(8):2064-2065. https://doi.org/10.1111/jth.14867
  21. Aggarwal G, Lippi G, Michael Henry B. Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature. Int J Stroke. 2020;15(4):385-389.  https://doi.org/10.1177/1747493020921664
  22. Lodigiani C, Iapichino G, Carenzo L, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9-14.  https://doi.org/10.1016/j.thromres.2020.04.024
  23. Cao X, Yin R, Albrecht H, et al. Cholesterol: A new game player accelerating vasculopathy caused by SARS-CoV-2? Am J Physiol Endocrinol Metab. 2020;319(1):197-202.  https://doi.org/10.1152/ajpendo.00255.2020
  24. Carod-Artal FJ. Neurological complications of coronavirus and COVID-19. Complicaciones neurológicas por coronavirus y COVID-19. Rev Neurol. 2020;70(9):311-322.  https://doi.org/10.33588/rn.7009.2020179
  25. Putilina MV. Risk factors, features of clinical course and treatment approaches in aged patients with cerebral stroke. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2011;111(5): 90-95. (In Russ.).
  26. Niazkar HR, Zibaee B, Nasimi A, Bahri N. The neurological manifestations of COVID-19: a review article. Neurol Sci. 2020;41(7):1667-1671. https://doi.org/10.1007/s10072-020-04486-3
  27. Gusev EI, Martynov MY, Boyko AN, et al. Novel coronavirus infection (COVID-19) and nervous system involvement: pathogenesis, clinical manifestations, organization of neurological care. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020;120(6):7-16. (In Russ.). https://doi.org/10.17116/jnevro20201200617
  28. Putilina MV, Soldatov M. Cerebral strokes in old age. Features of the clinical picture, course, treatment. Doctor. 2006(5):29-34. 
  29. Wu J, Li W, Shi X, et al. Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19). J Intern Med. 2020;288(1):128-138.  https://doi.org/10.1111/joim.13063
  30. Vremennye metodicheskie rekomendatsii. Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID-19) [Internet]. Versiya 8 (03.09.2020). Accessed Dec 10, 2020. https://minzdrav.midural.ru/article/show/id/10132
  31. Meng J, Xiao G, Zhang J, et al. Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. Emerg Microbes Infect. 2020;9(1):757-760.  https://doi.org/10.1080/22221751.2020.1746200
  32. Claire Wilcox, Zhou H. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020;129:98.  https://doi.org/10.1016/j.jpsychires.2020.06.022
  33. Qureshi AI, Abd-Allah F, Al-Senani F, et al. Management of acute ischemic stroke in patients with COVID-19 infection: Insights from an international panel. Am J Emerg Med. 2020;38(7):1548.e5-1548.e7.  https://doi.org/10.1016/j.ajem.2020.05.018
  34. Gromova OA, Torshin IY, Putilina MV, et al. Choice of neuroprotective therapy regimens in patients with chronic cerebral ischemia, taking into account the synergy of drug interactions. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020;120(8):42-50. (In Russ.). https://doi.org/10.17116/jnevro202012008142
  35. Putilina MV. Neuroprotective therapy of chronic brain ischemia. Doctor. 2008;(8): 27-34. (In Russ.).
  36. Lima Giacobbo B, Doorduin J, Klein HC, et al. Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation. Mol Neurobiol. 2019;56(5):3295-3312. https://doi.org/10.1007/s12035-018-1283-6
  37. Cavalli G, De Luca G, Campochiaro C, et al. Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study. Lancet Rheumatol. 2020;2(6):325-331.  https://doi.org/10.1016/S2665-9913(20)30127-2
  38. Nesterenko AN, Onufriev MV, Gulyaeva NV, et al. Effect of the drug Cortexin on free radical oxidation and inflammatory processes in rats with normal and accelerated aging. Neurochemistry. 2018;35(2):187-198. (In Russ.). https://doi.org/10.7868/S1027813318020127
  39. Yakovlev AA, Gulyaeva NV. Molecular partners of cortexin in the brain. Neurochemistry. 2017;33(1)91-96. (In Russ.). https://doi.org/10.1134/S1819712416040164
  40. Adriani W, Granstrem O, Romano E, et al. Modulatory effects of cortexin and cortagen on locomotor activity and anxiety-related behavior in mice. Open Neuropsychopharmacology Journal. 2009;2:22-29.  https://doi.org/10.2174/1876523800902010022
  41. Zykov VP, Serebrennikova EB, Panchenko TN, et al. Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018;118(3):27-31. (In Russ.). https://doi.org/10.17116/jnevro20181183127-31
  42. Belova LA, Mashin VV, Abramova VV, et al. Efficacy of Korteksin in acute period of hemispheric ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018;118(7):30-34. (In Russ.). https://doi.org/10.17116/jnevro20181187130
  43. Putilina MV. A personalized selection of choline precursors in evidence—based medicine. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020;120(6):144-151. (In Russ.). https://doi.org/10.17116/jnevro2020120061144
  44. Martí-Carvajal A, Valli C, Solà I, et al. Citicoline for treating people with acute ischemic stroke. Cochrane Database Syst Rev. 2020;8:CD013066. https://doi.org/10.1002/14651858.CD013066.pub2.
  45. Putilina MV, Natarova EB. Features of manifestations of cerebral circulation insufficiency in young patients. Russian Medical News. 2002;(2):41-44. (In Russ.).
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