Clinical effect of selective hemosorption of cytokines in patients with severe COVID-19: a systematic review

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OBJECTIVE

To evaluate the strategies and role of selective hemosorption of cytokines in the treatment of severe COVID-19 infection.

MATERIAL AND METHODS. S

Ystematic searching for available literature data on selective hemosorption of cytokines in patients with COVID-19 was performed in the PubMed and Elibrary databases.

RESULTS

We found 264 articles according to keywords. Considering inclusion criteria, we enrolled 22 full-text articles. Of these, four manuscripts were selected to estimate the effect of isolated selective cytokine hemosorption. Three articles were selected to study the effect of hemosorption combined with renal replacement therapy.

CONCLUSION. H

Eterogeneous data without control group in most studies and predominant small samples do not provide an opportunity to draw an unambiguous conclusion about clinical effect of various methods of efferent therapy. However, selective hemosorption of cytokines in the treatment of COVID-19 reduces mortality.

Keywords:

COVID-19

cytokine storm

cytokine sorption

hemoperfusion

treatment of COVID-19

cytokine adsorption

Authors:

Bukreeva G.G.

Sokolov North-Western Research Clinical Center

ORCID: 0000-0001-8789-1755

Simutis I.S.

Sokolov North-Western Research Clinical Center;
Mechnikov North-Western State Medical University

ORCID: 0000-0002-2537-0142

Abramovskiy S.V.

Sokolov North-Western Research Clinical Center

ORCID: 0000-0003-1227-0668

Prishlyak V.B.

Sokolov North-Western Research Clinical Center

ORCID: 0000-0003-0484-465X

Ratnikov V.A.

Sokolov North-Western Research Clinical Center;
St. Petersburg State Medical University

ORCID: 0000-0002-9645-8408

Shcheglov A.N.

Central Clinical Hospital with Polyclinic of Administrative Directorate of the President of the Russian Federation

ORCID: 0000-0002-3783-7918

Received:

08.08.2023

Accepted:

11.07.2024

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