A novel approach to differential diagnosis of Parkinson’s disease and essential tremor

Pokhabov D.V.

Federal Siberian Scientific and Clinical Center

ORCID: 0000-0001-5895-5043

Pokhabov D.D.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Federal Siberian Research Clinical Center

Abramov V.G.

Federal Siberian Research Clinical Center

SPIN RSCI: 7740-8633
Scopus AuthorID: 57197821252
ORCID: 0000-0002-4063-4951

Tunik M.E.

Voino-Yasenetsky Krasnoyarsk State Medical University

Tutsenko K.O.

Voino-Yasenetsky Krasnoyarsk State Medical University

Khoroshavina A.A.

Voino-Yasenetsky Krasnoyarsk State Medical University

Sadovsky M.G.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Institute of Computational Modeling of SB RAS

A novel approach to differential diagnosis of Parkinson’s disease and essential tremor

Authors:

Pokhabov D.V., Pokhabov D.D., Abramov V.G., Tunik M.E., Tutsenko K.O., Khoroshavina A.A., Sadovsky M.G.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12): 18‑24

DOI: 10.17116/jnevro202012012118

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To cite this article:

Pokhabov DV, Pokhabov DD, Abramov VG, Tunik ME, Tutsenko KO, Khoroshavina AA, Sadovsky MG. A novel approach to differential diagnosis of Parkinson’s disease and essential tremor. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12):18‑24. (In Russ.)
https://doi.org/10.17116/jnevro202012012118

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To study tremor and olfactory dysfunction in patients with Parkinson’s disease (PD), patients with essential tremor and healthy people for the differential diagnosis and to verify the hypothesis on the inverse dependence between tremor and olfactory dysfunction.

MATERIAL AND METHODS

Olfactory dysfunction was studied in 45 patients with PD, 40 patients with essential tremor and 64 healthy controls. Tremor was studied in 90 people, including 30 controls and 30 patients with PD and essential tremor. The olfactory function was tested with Sniffin’ Sticks test. Tremor parameters were studied with wireless monitoring instrument for electrophysiological signals record, where three essential data flows have been recorded: electromyogram, gyroscope and acceleration. The instrument recorded the frequency and amplitude of each parameter. The data were analyzed with IBM SPSS Statistica 2.3 software using standard methods. Besides, non-linear statistics using ViDaExpert software with elastic map technique was utilized.

RESULTS AND CONCLUSION

The elastic map perfectly separated the patients with PD and essential tremor, as well as healthy controls. Three clusters were observed. The analysis of composition of the clusters proved the better quality of olfactory function of the patients with essential tremor compared to the patients with PD. This bias confirms the hypothesis on the inverse dependence between the tremor level and olfactory dysfunction.

Keywords:

Parkinson’s disease

essential tremor

olfactory Sniffin’ Sticks test

tremor records

elastic map technique

Authors:

Pokhabov D.V.

Federal Siberian Scientific and Clinical Center

ORCID: 0000-0001-5895-5043

Pokhabov D.D.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Federal Siberian Research Clinical Center

Abramov V.G.

Federal Siberian Research Clinical Center

SPIN RSCI: 7740-8633
Scopus AuthorID: 57197821252
ORCID: 0000-0002-4063-4951

Tunik M.E.

Voino-Yasenetsky Krasnoyarsk State Medical University

Tutsenko K.O.

Voino-Yasenetsky Krasnoyarsk State Medical University

Khoroshavina A.A.

Voino-Yasenetsky Krasnoyarsk State Medical University

Sadovsky M.G.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Institute of Computational Modeling of SB RAS

Received:

04.03.2020

Accepted:

15.07.2020

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