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Gusev E.I.

Pirogov National Research Medical University

Katunina E.A.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Martynov M.U.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnology of the Federal Medical Biological Agency

Blokhin V.E.

Koltsov Institute of Developmental Biology RAS

Kalinkin A.L.

Medical Research and Education Center of Lomonosov Moscow State University

Alessenko A.V.

Institute of Biochemical Physic of the Russian Academy of Sciences

Nodel M.R.

Sechenov First Moscow State Medical University

Malykhina E.A.

Pirogov Russian National Research Medical University;
Federal Center for Brain and Neurotechnologies

Titova N.V.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Katunin D.A.

Pirogov Russian National Research Medical University;
Federal Center for Brain and Neurotechnologies

Shupik M.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Gutner U.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Maloshitskaya O.A.

Lomonosov Moscow State University

Sokolov S.A.

Lomonosov Moscow State University

Kucheryanu V.G.

Institute of General Pathology and Pathophysiology

Pavlova E.N.

Koltsov Institute of Developmental Biology RAS

Ugrumov M.V.

Koltsov Institute of Developmental Biology RAS

Development of early diagnosis of Parkinson’s disease based on the search for biomarkers such as premotor symptoms and changes in blood

Authors:

Gusev E.I., Katunina E.A., Martynov M.U., Blokhin V.E., Kalinkin A.L., Alessenko A.V., Nodel M.R., Malykhina E.A., Titova N.V., Katunin D.A., Shupik M.A., Gutner U.A., Maloshitskaya O.A., Sokolov S.A., Kucheryanu V.G., Pavlova E.N., Ugrumov M.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12): 7‑17

DOI: 10.17116/jnevro20201201217

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To cite this article:

Gusev EI, Katunina EA, Martynov MU, et al. . Development of early diagnosis of Parkinson’s disease based on the search for biomarkers such as premotor symptoms and changes in blood. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12):7‑17. (In Russ.)
https://doi.org/10.17116/jnevro20201201217

 
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OBJECTIVE

To determine changes in the chemical composition of blood plasma in subjects at risk of Parkinson’s disease (PD) at the prodromal stage compared with age control.

MATERIAL AND METHODS

Subjects at risk were selected for the presence of characteristic premotor symptoms, including impairments of sleep, olfaction and constipation.The risk group included 12 people, the control group — 8 people.

RESULTS

Among seven catecholamines and their metabolites detected in the blood, only the concentration of L-dioxiphenylalanine (L-DOPA) changed (decreased) in subjects at risk compared with the control. A decrease in the concentration of L-DOPA is considered as a manifestation (marker) of selective degeneration of central and peripheral catecholaminergic neurons in PD. In contrast to L-DOPA, the concentration of seven of the twelve detected sphingomyelins in the blood of the subjects at risk increased. Given that a change in the metabolism of sphingomyelins is associated with processes such as apoptosis, autophagy, and synucleinopathy, an increase in their concentration in the blood of patients at risk is considered as a manifestation of systemic general degeneration of central and peripheral neurons. Finally, in the blood of subjects at risk, we found a trend towards a decrease in the concentration of urates, which are endogenous neuroprotectors.

CONCLUSION

The changes in the level of L-DOPA, sphingmyelins and urates in the blood of subjects at risk may serve as diagnostic markers of PD at the prodromal stage.

Keywords:

neurodegenerative diseases
Parkinson’ disease
early diagnostics
blood markers
premotor symptoms

Authors:

Gusev E.I.

Pirogov National Research Medical University

Katunina E.A.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Martynov M.U.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnology of the Federal Medical Biological Agency

Blokhin V.E.

Koltsov Institute of Developmental Biology RAS

Kalinkin A.L.

Medical Research and Education Center of Lomonosov Moscow State University

Alessenko A.V.

Institute of Biochemical Physic of the Russian Academy of Sciences

Nodel M.R.

Sechenov First Moscow State Medical University

Malykhina E.A.

Pirogov Russian National Research Medical University;
Federal Center for Brain and Neurotechnologies

Titova N.V.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Katunin D.A.

Pirogov Russian National Research Medical University;
Federal Center for Brain and Neurotechnologies

Shupik M.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Gutner U.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Maloshitskaya O.A.

Lomonosov Moscow State University

Sokolov S.A.

Lomonosov Moscow State University

Kucheryanu V.G.

Institute of General Pathology and Pathophysiology

Pavlova E.N.

Koltsov Institute of Developmental Biology RAS

Ugrumov M.V.

Koltsov Institute of Developmental Biology RAS

Received:

03.08.2020

Accepted:

11.08.2020

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