Clinical and electrophysiological parameters of alcohol dependence and its comorbidity with affective disorders

Galkin S.A.; Roshchina O.V.; Kisel N.I.; Ivanova S.A.; Bokhan N.A.

doi:https://doi.org/10.17116/jnevro202012010156

Galkin S.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-7709-3917

Roshchina O.V.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Kisel N.I.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Ivanova S.A.

Tomsk National Research Medical Center of the Russian Academy of Sciences

ORCID: 0000-0001-7078-323X

Bokhan N.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-1052-855X

Clinical and electrophysiological parameters of alcohol dependence and its comorbidity with affective disorders

Authors:

Galkin S.A., Roshchina O.V., Kisel N.I., Ivanova S.A., Bokhan N.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10): 56‑59

DOI: 10.17116/jnevro202012010156

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To cite this article:

Galkin SA, Roshchina OV, Kisel NI, Ivanova SA, Bokhan NA. Clinical and electrophysiological parameters of alcohol dependence and its comorbidity with affective disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10):56‑59. (In Russ.)
https://doi.org/10.17116/jnevro202012010156

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

OBJECTIVE

To identify characteristics of and possible differences in clinical and electroencephalographic parameters in patients with alcohol dependence with- and without comorbid affective disorders.

MATERIALS AND METHODS

Ninety-five patients, including 74 with an established diagnosis of alcohol dependence and 21 with alcohol dependence and affective disorders, were examined. Duration of alcohol dependence and affective disorder (years), number of hospitalizations and suicidal attempts were analyzed as anamnestic data. Hamilton’s anxiety and depression scale (HDRS), the Alcohol Use Disorders Identification Test (AUDIT), the General clinical impression scale (CGI-s) were used as psychometric tools. The study of bioelectric activity of the brain was carried out using a 16-channel encephalograph. The background electroencephalogram was recorded, the values of absolute spectral power and coherence of theta, alpha and beta rhythms were analyzed.

RESULTS AND CONCLUSION

Patients with comorbidity of alcohol dependence and affective disorders have a significantly higher risk of suicidal behavior, a greater frequency of hospitalizations, higher levels of anxiety compared with patients without affective disorders. Electrophysiological data have shown that patients with comorbidity of alcohol dependence and affective disorders have higher values of spectral power of alpha-rhythm in all parts of the cerebral cortex (except for temporal lobes) and beta-rhythm in the occipital cortex, as well as an increase in interhemispheric coherence in all frequency ranges.

Keywords:

alcohol dependence

affective disorders

comorbidity

clinical characteristics

electroencephalography

Authors:

Galkin S.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-7709-3917

Roshchina O.V.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Kisel N.I.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Ivanova S.A.

Tomsk National Research Medical Center of the Russian Academy of Sciences

ORCID: 0000-0001-7078-323X

Bokhan N.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-1052-855X

Received:

02.04.2020

Accepted:

10.04.2020

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