Impairment of executive functions in patients with alcohol use disorders

Galkin S.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-7709-3917

Authors:

Galkin S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(6): 110‑114

DOI: 10.17116/jnevro2024124061110

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To cite this article:

Galkin SA. Impairment of executive functions in patients with alcohol use disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(6):110‑114. (In Russ.)
https://doi.org/10.17116/jnevro2024124061110

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To study the features of executive functions in patients with alcohol use disorders and comorbid exogenous organic brain damage of non-alcoholic nature.

MATERIAL AND METHODS

Sixty-five men, aged 24 to 55 years, with alcohol use disorders were examined. Thirty mentally healthy men were examined as a control group. To assess executive functioning, standard neuropsychological tests were used: the Go/No-Go task, the Corsi test and the Stroop Color Test.

RESULTS

Patients with alcohol use disorders and comorbid exogenous organic brain damage made significantly more errors in the Go/No-Go task (skipping the Go signal: p=0.004) and performed the Stroop Color test longer (task completion time: p=0.003). According to multivariate regression analysis, the presence of exogenous organic brain damage predicted the worst indicators of psychomotor reaction (p=0.009) and cognitive flexibility (p=0.021).

CONCLUSION

Comorbid exogenous organic brain damage in patients with alcohol use disorders leads to a significant deterioration of executive functions, including psychomotor reaction and cognitive flexibility, compared with patients suffering only from alcohol use disorders.

Keywords:

alcohol use disorders

exogenous organic brain damage

executive functions

psychomotor reaction

cognitive flexibility

Authors:

Galkin S.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-7709-3917

Received:

04.10.2023

Accepted:

31.01.2024

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