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Anikin G.S.

Sechenov First Moscow State Medical University, Moscow, Russia

Makhova A.A.

Sechenov First Moscow State Medical University, Moscow, Russia

Shikh E.V.

Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Prospects of application of acetyl-L-carnitine in neurology and psychiatry (the treatment of polyneuropathy and depressive states)

Authors:

Anikin G.S., Makhova A.A., Shikh E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(8): 130‑135

DOI: 10.17116/jnevro2019119081130

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Table of contents

PROSPECTS OF APPLICATION OF ACETYL-L-CARNITINE IN NEUROLOGY AND PSYCHIATRY (THE TREATMENT OF POLYNEUROPATHY AND DEPRESSIVE STATES)
PROSPECTS OF APPLICATION OF ACETYL-L-CARNITINE IN NEUROLOGY AND PSYCHIATRY (THE TREATMENT OF POLYNEUROPATHY AND DEPRESSIVE STATES)

To cite this article:

Anikin GS, Makhova AA, Shikh EV. Prospects of application of acetyl-L-carnitine in neurology and psychiatry (the treatment of polyneuropathy and depressive states). S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(8):130‑135. (In Russ.)
https://doi.org/10.17116/jnevro2019119081130

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Acetyl-L-carnitine (ALA) is a biologically active form of L-carnitine, which is a readily available substrate for triggering energy-dependent metabolic processes in the mitochondria. The mechanism of the protective effect of ALA on brain tissue is a significant reduction in the amount of oxygen consumed for energy supply of the needs of the nervous system. ALA also has antioxidant and antiapoptotic activity. In addition, ALK plays a neuromodulating effect on both synaptic morphology and synaptic transmission. The similarity in structure with acetylcholine allows to have a cholinomimetic effect, as well as to show neuroprotective and neurotrophic properties. ALK has an antidepressant and analgesic effect in painful neuropathies. Therefore, ALA is a promising drug for the treatment of polyneuropathy of various origins. Compared with antidepressants efficacy and a minimum of side effects open up wide possibilities of using ALA in the treatment of depression with a low risk of developing NLR.

Keywords:

polyneuropathy
depression
acetyl-L-carnitine

Authors:

Anikin G.S.

Sechenov First Moscow State Medical University, Moscow, Russia

Makhova A.A.

Sechenov First Moscow State Medical University, Moscow, Russia

Shikh E.V.

Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

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References:

  1. Acetyl-L-carnitine. Monograph. Altern Med Rev. 2010;15:76-83.
  2. Furlong JH. Acetyl-L-carnitine:metabolism and application in clinical practis. Altern Med Ref. 1996;1:85-93.
  3. Onofrj M, Ciccocioppo F, Varanese S, di Muzio A, Calvani M, Chiechio S, Osio M, Thomas A. Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. Expert Rev Neurother. 2013;13:925-936.
  4. Chiechio S, Caricasole A, Barletta E, Storto M, Catania MV, Copani A, Vertechy M, Nicolai R, Calvani M, Melchiorri D, Nicoletti FL-acetylcarnitine induces analgesia by selectively up-regulating mglu2 metabotropic glutamate receptors. Mol Pharmacol. 2002;61:989-996.
  5. Chiechio S, Copani A, Zammataro M, Battaglia G, Gereau RW 4th, Nicoletti F. Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain. Trends Pharmacol Sci. 2010;31:153-160.
  6. Wang F, Zhang J, Yu J, Liu S, Zhang R, Ma X, Wang P. Diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy: a systematic review and meta-analysis. Journal of Diabetes Research. 2017;8787261. https://doi.org/10.1155/2017/8787261
  7. Boulton AJ, Malik RA, Arezzo JC, Malik RA, Arezzo JC, Sosenko JM. Diabetic somatic neuropathies. Diabetes Care. 2004;27:1458-1486.
  8. Markesbery WR, Procopis PG, Harrison AR, Engel AG. Muscle carnitine deficiency: association with lipid myopathy, vacuolar neuropathy and vacuolated leucocytes. Arch Neurol. 1974;31:320-324.
  9. Bin Aleem S, Hussain MM, Farooq Y. Levo-carnitine reduces oxidative stress and improves contractile functions of fast muscles in type 2 diabetic rats. Iran Biomed J. 2013;17(1):29-35.
  10. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. Drugs R D. 2002;3(4):223-231.
  11. Li S, Chen X, Li Q, Du J, Liu Z, Peng Y, Xu M, Li Q, Lei M, Wang C, Zheng S, Zhang X, Yu H, Shi J, Tao S, Feng P, Tian H. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig. 2016;7(5):777-785. Epub 2016 Mar 28. PubMed PMID: 27180954; PubMed Central PMCID: PMC5009142. https://doi.org/10.1111/jdi.12493
  12. Veronese N, Sergi G, Stubbs B, Bourdel-Marchasson I, Tessier D, Sieber C, Strandberg T, Gillain S, Barbagallo M, Crepaldi G, Maggi S, Manzato E. Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis. Eur Geriatr. 2017;8:2:117-122.
  13. Mondal S, Choudhury KB, Sharma S, Gupta A, Dutta S. Comparative study among glutamine, acetyl-Lcarnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy. Clin Cancer Investig J. 2014;3:213-219.
  14. Youle M, Osio M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV Med. 2007;8:241-250.
  15. Ilias I, Manoli I, Blackman MR, Gold PW, Alesci S. L-Carnitine and acetyl-L-carnitine in the treatment of complications associated with HIV infection and antiretroviral therapy. Mitochondrion. 2004;4(2-3):163-168.
  16. Cruccu G, Di Stefano G, Fattapposta F, Jann S, Padua L, Schenone A, & Truini A. L-Acetyl-carnitine in patients with carpal tunnel syndrome: effects on nerve protection, hand function and pain. CNS drugs. 2017;31(12):1103-1111. https://doi.org/10.1007/s40263-017-0476-2
  17. Davydov OS, Yakhno NN, Kukushkin ML i dr. Neuropathic pain. Clinical recommendations for diagnosis and treatment. M. 2018. (In Russ.)
  18. https://www.who.int/ru/news-room/fact-sheets/detail/depression
  19. Chiechio S, Pier Luigi Canonico. L-Acetylcarnitine: a mechanistically distinctive and potentially rapid-acting antidepressant drug. Int J Mol Sci. 2018;19:11. https://doi.org/10.3390/ijms19010011
  20. Wang S-M, Han C, Lee S-J. A review of current evidence for acetyl-L-carnitine in the treatment of depression. Journal of Psychiatric Research. 2014;53:30-37.
  21. Nasca C, Xenos D, Barone Y, Caruso A, Scaccianoce S, Matrisciano F, Nicoletti F. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(12):4804-4809. https://doi.org/10.1073/pnas.1216100110
  22. Kesse-Guyot E, Touvier M, Andreeva VA, Jeandel C, Ferry M, Hercberg S, Galan P. Cross-sectional but not longitudinal association between n-3 fatty acid intake and depressive symptoms: results from the SU.VI.MAX 2 study. American Journal of Epidemiology. 2012;175:979-987.
  23. Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A, Beasley J, Millington DS, Mathé AA, Kocsis JH, Murrough JW, McEwen BS, Rasgon N. Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proceedings of the National Academy of Sciences of the United States of America. 115(34):627-8632. https://doi.org/10.1073/pnas.1801609115
  24. Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine supplementation and the treatment of depressive symptoms: a systematic review and meta-analysis. Psychosom Med. 2018;80(2):154-159.
  25. Bersani G, Meco G, Denaro A, Liberati D, Colletti C, Nicolai R, Bersani FS, Koverech A. L-Acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs. fluoxetine. Eur Neuropychopharmacol. 2013;23(10):1219-1225.
  26. Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami S. Double-blind, multicenter trial comparing acetyl-L-carnitine with placebo in the treatment of fibromyalgia patients. Clinical and Experimental Rheumatology. 2007;25:182-188.
  27. Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, Gargante MP, Motta M, Mistretta A, Rampello L, Pennisi G. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Scandinavian Journal of Gastroenterology. 2011;46:750-759.
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