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Kiselev A.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Vostrikova E.V.

Kafedra klinicheskoĭ nevrologii i algologii GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii, Novosibirsk

Kalinina T.S.

Zakusov Institute of Pharmacology, Moscow, Russia

Stovbun S.V.

Institut khimicheskoĭ fiziki im. N.N. Semenova RAN, Moskva

A randomized, double-blind, placebo-controlled study of the efficacy and safety of ampasse in the treatment of chronic cerebral ischemia

Authors:

Kiselev A.V., Vostrikova E.V., Kalinina T.S., Stovbun S.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4): 21‑25

DOI: 10.17116/jnevro201911904121

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To cite this article:

Kiselev AV, Vostrikova EV, Kalinina TS, Stovbun SV. A randomized, double-blind, placebo-controlled study of the efficacy and safety of ampasse in the treatment of chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4):21‑25. (In Russ.)
https://doi.org/10.17116/jnevro201911904121

 
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Objective. To study the efficacy and safety of ampasse in the treatment of chronic cerebral ischemia. Material and methods. A randomized, double-blind, placebo-controlled study of the efficacy and safety of the 5-hydroxy-3-carboxypyridine-L-glutamine acid monocalcium salt (ampasse) was performed in 80 patients, aged from 50 to 75 years, with chronic cerebrovascular accident due to arterial hypertension and/or atherosclerosis of the main arteries of the head. The drug was used in daily doses of 5, 10, or 25 mg intravenously once a day for 15 days. Sodium chloride 0.9% was used as a placebo. Results and conclusion. It has been established that ampasse improves the state of patients with chronic cerebral ischemia in relation to depression, sleep quality and cognitive functions.

Keywords:

nootropics
chronic cerebral ischemia
cognitive functions
depression
sleep disorders

Authors:

Kiselev A.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Vostrikova E.V.

Kafedra klinicheskoĭ nevrologii i algologii GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii, Novosibirsk

Kalinina T.S.

Zakusov Institute of Pharmacology, Moscow, Russia

Stovbun S.V.

Institut khimicheskoĭ fiziki im. N.N. Semenova RAN, Moskva

List of references:

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  2. Vereshchagin NV, Suslina ZA, Maksimova MYu. Arterial hypertension and cerebrovascular pathology: a modern view of the problem. Cardiology. 2004;3:4-8. (In Russ.)
  3. Lu M, Peng P, Cui Y, Qiao H, Li D, Cai J, Zhao X. Association of Progression of Carotid Artery Wall Volume and Recurrent Transient Ischemic Attack or Stroke: A Magnetic Resonance Imaging Study. Stroke. 2018;49(3):614-620.
  4. Pires PW, Dams Ramos CM, Matin N, Dorrance AM. The effects of hypertension on the cerebral circulation. Am J Physiol Heart Circ Physiol. 2013;304:1598-1614.
  5. Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A, Montezano AC. Vascular smooth muscle contraction in hypertension. Cardiovasc Res. 2018;114(4):529-539. https://doi.org/10.1093/cvr/cvy023
  6. Pires PW, Jackson WF, Dorrance A M. Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. Am J Physiol Heart Circ Physiol. 2015;309(1):127-136. https://doi.org/10.1152/ajpheart.00168.2015
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  9. Kiselev AV, Stovbun SV, Sergienko VI. Study of the nootropic effects of D- and L-isomers of N-(5-hydroxynicotinoyl)-glutamic acid. Bulletin of the Moscow State Regional University. Series: Natural Sciences. 2011;2:47-49. (In Russ.)
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  11. Kiselev AV, Kalinina TS, Stovbun SV. The gliaprotection effect «Ampassea» as possible mechanism recovery of function CNS on the intracerebral hematoma model. The International Journal of Neuropsychopharmacology. 2016;19(suppl 1):45.
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  15. Kryger MH, Roth T, Dement WC. Principles and Practice of Sleep Medicine. 6th ed. Philadelphia, PA, USA: Elsevier; 2016.

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