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Kiselev A.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Vostrikova E.V.

Kafedra klinicheskoĭ nevrologii i algologii GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii, Novosibirsk

Kalinina T.S.

Zakusov Institute of Pharmacology, Moscow, Russia

Stovbun S.V.

Institut khimicheskoĭ fiziki im. N.N. Semenova RAN, Moskva

A randomized, double-blind, placebo-controlled study of the efficacy and safety of ampasse in the treatment of chronic cerebral ischemia

Authors:

Kiselev A.V., Vostrikova E.V., Kalinina T.S., Stovbun S.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4): 21‑25

DOI: 10.17116/jnevro201911904121

Read: 5055 times

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Table of contents

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF AMPASSE IN THE TREATMENT OF CHRONIC CEREBRAL ISCHEMIA
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF AMPASSE IN THE TREATMENT OF CHRONIC CEREBRAL ISCHEMIA

To cite this article:

Kiselev AV, Vostrikova EV, Kalinina TS, Stovbun SV. A randomized, double-blind, placebo-controlled study of the efficacy and safety of ampasse in the treatment of chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4):21‑25. (In Russ.)
https://doi.org/10.17116/jnevro201911904121

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Использование инфографики авторами научных работ
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Abstract:

Objective. To study the efficacy and safety of ampasse in the treatment of chronic cerebral ischemia. Material and methods. A randomized, double-blind, placebo-controlled study of the efficacy and safety of the 5-hydroxy-3-carboxypyridine-L-glutamine acid monocalcium salt (ampasse) was performed in 80 patients, aged from 50 to 75 years, with chronic cerebrovascular accident due to arterial hypertension and/or atherosclerosis of the main arteries of the head. The drug was used in daily doses of 5, 10, or 25 mg intravenously once a day for 15 days. Sodium chloride 0.9% was used as a placebo. Results and conclusion. It has been established that ampasse improves the state of patients with chronic cerebral ischemia in relation to depression, sleep quality and cognitive functions.

Keywords:

nootropics
chronic cerebral ischemia
cognitive functions
depression
sleep disorders

Authors:

Kiselev A.V.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Vostrikova E.V.

Kafedra klinicheskoĭ nevrologii i algologii GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii, Novosibirsk

Kalinina T.S.

Zakusov Institute of Pharmacology, Moscow, Russia

Stovbun S.V.

Institut khimicheskoĭ fiziki im. N.N. Semenova RAN, Moskva

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References:

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