Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children

Zykov V.P.; Serebrennikova E.B.; Panchenko T.N.; Sycheva Ya.B.; Presnyakova S.N.; Mazur E.L.; Salova M.N.; Golubeva E.S.; Khromova S.K.

doi:https://doi.org/10.17116/jnevro20181183127-31

Zykov V.P.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Serebrennikova E.B.

Vagner Perm State Academy of Medicine, Perm

Panchenko T.N.

Novokuznetsk Chied Clinical Psychoneurological Sanatorium, Novokuznetsk, Russia

Sycheva Ya.B.

Regional Child Hospital, Tomsk, Russia

Presnyakova S.N.

Regional Child Hospital, Tomsk, Russia

Mazur E.L.

Regional Child Clinical Hospital, Belgorod, Russia

Salova M.N.

Evpatoria City Child Clinical Hospital, Yevpatoriya, Russia

Golubeva E.S.

Vologda Child City Polyclinic №3, Vologda, Russia

Khromova S.K.

Lipetsk City Child Hospital, Lipetsk, Russia

Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children

Authors:

Zykov V.P., Serebrennikova E.B., Panchenko T.N., Sycheva Ya.B., Presnyakova S.N., Mazur E.L., Salova M.N., Golubeva E.S., Khromova S.K.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3): 27‑31

DOI: 10.17116/jnevro20181183127-31

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To cite this article:

Zykov VP, Serebrennikova EB, Panchenko TN, et al. . Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3):27‑31. (In Russ.)
https://doi.org/10.17116/jnevro20181183127-31

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study the efficacy and tolerability of cortexin in the treatment of cognitive dysfunction in children. Material and methods. The study included 635 patients, aged 3—7 years. Patients were divided into 4 clinical groups: group 1 (269 children with attention deficit hyperactivity disorder (ADHD)), group 2 (215 children with speech delay), group 3 (82 patients with the consequences of a perinatal lesion of the central nervous system), group 4 (69 patients with asthenic/neurotic syndrome). Attention, visual memory and thinking were assessed before and after treatment. Standard treatment of cortexin, including 10 intramuscular injections, was used. Results and conclusion. The reliable effect of cortexin on cognitive impairment was shown. The best response to treatment was observed in patients with ADHD, aged 3—4 years, in particular on the tests measuring thinking. The tolerability of cortexin was good. It has been concluded that cortexin is an effective drug for treatment of children with ADHD, speech delay and consequences of a perinatal lesion of the central nervous system.

Keywords:

cortexin

attention deficit hyperactivity disorder

speech delay disorder

cognitive dysfunction

Authors:

Zykov V.P.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Serebrennikova E.B.

Vagner Perm State Academy of Medicine, Perm

Panchenko T.N.

Novokuznetsk Chied Clinical Psychoneurological Sanatorium, Novokuznetsk, Russia

Sycheva Ya.B.

Regional Child Hospital, Tomsk, Russia

Presnyakova S.N.

Regional Child Hospital, Tomsk, Russia

Mazur E.L.

Regional Child Clinical Hospital, Belgorod, Russia

Salova M.N.

Evpatoria City Child Clinical Hospital, Yevpatoriya, Russia

Golubeva E.S.

Vologda Child City Polyclinic №3, Vologda, Russia

Khromova S.K.

Lipetsk City Child Hospital, Lipetsk, Russia

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