Peptidergic nootropic therapy in cerebral palsy associated with epilepsy

Kholin A.A.; Zavadenko N.N.; Il'ina E.S.; Kolpakchi L.M.; Fedoniuk I.D.; Bembeeva R.Ts.; Esipova E.S.

doi:https://doi.org/10.17116/jnevro20171179137-42

Kholin A.A.

Neurology, Neurosurgery and Medical Genetics Department of Pediatric Faculty, Pirogov Russian National Research Medical University of the Russian Federation Ministry of Health;
Department of Psychoneurology №2, Russian Children Clinical Hospital of the Russian Federation Ministry of Health

Zavadenko N.N.

Kafedra nevrologii i neĭrokhirurgii pediatricheskogo fakulteta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Il'ina E.S.

Rossiĭskaia detskaia klinicheskaia bol'nitsa (RDKB), Moskva

Kolpakchi L.M.

Rossiĭskaia detskaia klinicheskaia bol'nitsa (RDKB), Moskva

Fedoniuk I.D.

Rossiĭskaia detskaia klinicheskaia bol'nitsa (RDKB), Moskva

Bembeeva R.Ts.

Pirogov Russian National Research Medical University, Moscow

Esipova E.S.

Neurology, Neurosurgery and Medical Genetics Department of Pediatric Faculty, Pirogov Russian National Research Medical University of the Russian Federation Ministry of Health

Peptidergic nootropic therapy in cerebral palsy associated with epilepsy

Authors:

Kholin A.A., Zavadenko N.N., Il'ina E.S., Kolpakchi L.M., Fedoniuk I.D., Bembeeva R.Ts., Esipova E.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9): 37‑42

DOI: 10.17116/jnevro20171179137-42

Read: 2721 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Kholin AA, Zavadenko NN, Il'ina ES, Kolpakchi LM, Fedoniuk ID, Bembeeva RTs, Esipova ES. Peptidergic nootropic therapy in cerebral palsy associated with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9):37‑42. (In Russ.)
https://doi.org/10.17116/jnevro20171179137-42

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Potential of animal-derived neuropeptides in complex therapy of diabetic neuropathy in patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):83-87

The possibility of using neurotropic therapy in patients with persistent postural-perceptual dizziness. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):89-94

Proinflammatory cytokines — as a marker of the effectiveness of neuroprotection in children with perinatal nervous system damage. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):62-66

The potential of cortical electrical stimulation for the study of autonomic dysfunction in patients with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):25-34

The role of neuroinflammation in the development of seizure activity and autonomic disorders in patients with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):50-58

Targets of rational neuroprotection in the therapy of chronic cerebral ischemia and the possibilities of achieving them. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):96-101

Epileptogenesis and risk factors of symptomatic epileptic seizures in patients with acute cerebrovascular accidents. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):26-31

The relationship between the interictal parameters of cardiovascular autonomic regulation and the outcomes of surgical treatment of epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):50-59

A personalized approach to the diagnosis of epilepsy in obese children. Laboratory Service. 2025;(1):5-12

Complex balneotherapy at the stage of spa treatment of children with cerebral palsy. Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;(3):29-37

Abstract:

Objective. To assess the efficacy and safety of сortexin in the treatment of children with cerebral palsy (CP) combined with epilepsy. Material and methods. Eighty-four patients (55 boys and 29 girls), aged from 1 to 11 years, with CP combined with epilepsy received cortexin together with antiepileptic drugs (AEDs). Cortexin was administered in doses of 5—10 mg depending on the patient’s age and body weight intramuscularly during hospitalization. Results and conclusion. Cortexin as add-on to AEDs reduced for more than two times the number of seizures, along with improvement of motor function, in 31 (36.9%) patients. The improvement of motor function, but without a significant decrease in epileptic seizures, was achieved in 15 (17.8%) of the patients. Reduction of epileptic seizures frequency (>2 times), but without a significant effect on motor function, was observed in 14 cases (16.7%). Twenty-three patients (27.4%) did not respond the therapy. The aggravation of epileptic seizures during cortexin therapy was observed in only 1 girl with West syndrome (1.2%), and this was significantly lower than the probability of seizures aggravation on AED. Polypeptide nootropic medication cortexin demonstrated efficacy and safety as adjunctive therapy in children with CP combined with epilepsy.

Keywords:

epilepsy

cerebral palsy

cortexin

polypeptide nootropic drugs

Authors:

Kholin A.A.

Zavadenko N.N.

Kafedra nevrologii i neĭrokhirurgii pediatricheskogo fakulteta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Il'ina E.S.

Rossiĭskaia detskaia klinicheskaia bol'nitsa (RDKB), Moskva

Kolpakchi L.M.

Rossiĭskaia detskaia klinicheskaia bol'nitsa (RDKB), Moskva

Fedoniuk I.D.

Rossiĭskaia detskaia klinicheskaia bol'nitsa (RDKB), Moskva

Bembeeva R.Ts.

Pirogov Russian National Research Medical University, Moscow

Esipova E.S.

Neurology, Neurosurgery and Medical Genetics Department of Pediatric Faculty, Pirogov Russian National Research Medical University of the Russian Federation Ministry of Health

Close metadata

References:

Belousova ED. Risk factors, management and prognosis of seizures and epilepsy in children with cerebral palsy: Dis... d-ra med. nauk. M. 2004. (In Russ.).
Zelnik N, Konopnicki M, Bennett-Back O, Castel-Deutsch T, Tirosh E. Risk factors for epilepsy in children with cerebral palsy. Eur J Paediatr Neurol. 2010;14(1):67-72. https://doi.org/10.1016/j.ejpn.2009.06.002
Garfinkle J, Shevell MI. Cerebral palsy, developmental delay, and epilepsy after neonatal seizures. Pediatr Neurol. 2011;44(2):88-96. https://doi.org/10.1016/j.pediatrneurol.2010.09.001
Mert GG, Incecik F, Altunbasak S, Herguner O, Mert MK, Kiris N, Unal I. Factors affecting epilepsy development and epilepsy prognosis in cerebral palsy. Pediatr Neurol. 2011;45(2):89-94. https://doi.org/10.1016/j.pediatrneurol.2011.03.001
Kholin AA, Zavadenko NN, Esipova ES. Cerebral palsy and epilepsy. Voprosy prakticheskoy pediatrii. 2016;11(4):66-72. (In Russ.). https://doi.org/10.20953/1817-7646-2016-4-66-72
Guzeva VI, Trubacheva AN. Kortexin application in the multimodal treatment of epilepsy in children. Terra Medica. 2003;2:19-21. (In Russ.).
Nemkova SA, Namazova-Baranova LS, Maslova OI, Zavadenko NN, Kholin AA, Karkashadze GA, Mamedyarov AM, Nesterovskiy YuE, Govorun SV. Cerebral palsy: diagnosis and correction of cognitive disorders. M.: The Union of Pediatricians of Russia; 2012. (In Russ.).
Fedunova GV, Sysoeva EN. Experience of using cortexin with symptomatic epilepsy in children. Glavnyj vrach. 2008;4(16):32. (In Russ.).
Tsigan VN, Miroliubov AV, Bogoslovskiy MM, Fedoseev VM. Cortexin efficiency in the treatment of epilepsy. Terra Medica Nova. 2008;4:20-24. (In Russ.).
Studenikin VM, Pak LA, Shelkovskij VI, Balkanskaya SV. Application cortexin Pediatric Neurology: experience and prospects. Farmateka. 2008;14:23-29. (In Russ.).
Nemkova SA, Maslova OI, Karkashadze GA, Zavadenko NN, Kurbatov YN. Current issues in diagnosis and treatment of cognitive disorders in children with cerebral palsy. Pediatric pharmacology. 2012;9(3):77-84. (In Russ.). https://doi.org/10.15690/pf.v9i3.327
Nemkova SA, Maslova OI, Karkashadze GA, Kurbatov YN, Podkorytova IV. The polypeptide stimulator application in complex treatment of cognitive disorders in children with diseases of the central nervous system. Pediatric pharmacology. 2012;9(5):80-84. (In Russ.). https://doi.org/10.15690/pf.v9i5.460
Kholin AA, Il`ina ES, Bembeeva RC, Simbirtseva EG, Kolpakchi LM, Fedonyuk ID, Nemkova SA, Zavadenko NN. Epilepsy in children with cerebral palsy. IV Baltic congress on pediatric neurology. Proceedings. SPb. 2013;346-347. (In Russ.).
Ivannikova NV, Jesaulova IV, Avdonina VJu, Kuksina LV. Cortexin a comprehensive habilitation and rehabilitation of children with disabilities. Terra Medica (Special issue). 2004;7-8. (In Russ.).
Isanova VA, Ismagilov MF. Cortexin in complex rehabilitation of patients with cerebral palsy. Nevrol vestn. 2008;15(4):125-127. (In Russ.).
Kojevnikova VYu, Kalacheva IO, Shprekher BL. Experience of Cortexin usage in the complex treatment of patients with drug-resistant epilepsy. Pediatria. The journal named after G.N. Speranskiy. 2010; 89(3):106-110. (In Russ.).
Koroleva NJu, Voronkova KV, Tarabrin PP. Cognitive impairment in patients with epilepsy, the effect of antiepileptic therapy and correction of violations. Obozrenie psihiat i med psihol im VM Behtereva. 2010;4:41-46. (In Russ.).