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Morozova A.Yu.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zubkov E.A.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zorkina Ia.A.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo"

Reznik A.M.

Gosudarstvennyĭ institut usovershenstvovaniia vracheĭ Ministerstva oborony RF, Moskva

Kostyuk G.P.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Chekhonin V.P.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo";
Kafedra meditsinskikh nanobiotekhnologiĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova

Genetic aspects of schizophrenia

Authors:

Morozova A.Yu., Zubkov E.A., Zorkina Ia.A., Reznik A.M., Kostyuk G.P., Chekhonin V.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(6): 126‑132

DOI: 10.17116/jnevro201711761126-132

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Table of contents

GENETIC ASPECTS OF SCHIZOPHRENIA
GENETIC ASPECTS OF SCHIZOPHRENIA

To cite this article:

Morozova AYu, Zubkov EA, Zorkina IaA, Reznik AM, Kostyuk GP, Chekhonin VP. Genetic aspects of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(6):126‑132. (In Russ.)
https://doi.org/10.17116/jnevro201711761126-132

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Schizophrenia is a disease with a complex non-Mendelian inheritance mechanism in most cases involving the combined action of a large number of genes. Identifying of genomic variations associated with schizophrenia endophenotypes has a great potential. This review describes genetic markers of the disease, current methods of their analysis, including genome-wide association study (GWAS). Certain genes with mutations that increase the risk of schizophrenia are described. Functional polymorphisms with phenotypic expression, which are significantly associated with clinical manifestation of schizophrenia, can serve as useful genetic markers. The authors highlight that currently there are no certain susceptibility genes. Further global research and search for markers in different population groups are needed.

Keywords:

schizofrenia
genetics
endofenotypes
genetic markers

Authors:

Morozova A.Yu.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zubkov E.A.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zorkina Ia.A.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo"

Reznik A.M.

Gosudarstvennyĭ institut usovershenstvovaniia vracheĭ Ministerstva oborony RF, Moskva

Kostyuk G.P.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Chekhonin V.P.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo";
Kafedra meditsinskikh nanobiotekhnologiĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova

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References:

  1. Tiganov A.S. Schizophrenia. Psychiatry. A Guide for Physicians. Ed. Tiganov A.S. M.: Medicine; 2012. (In Russ.) .
  2. Ensill RJ, Holliday S, Higenbottema J, eds. Schizophrenia. The study of the spectrum of psychosis. Medicine; 2001. (In Russ.) .
  3. Fleischhacker WW, Arango C, Arteel P, Barnes TRE, Carpenter W, Duckworth K, Galderisi S, Halpern L, Knapp M, Marder SR, Moller M, Sartorius N, Woodruff P. Schizophrenia — time to commit to policy change. Schizophrenia Bulletin. 2014;40(suppl 3):165-194. https://doi.org/10.1093/schbul/sbu006
  4. Kasckov J, Felmet K, Zisook S. Managing Suicide Risk in Patients with Schizophrenia. CNS Drugs. 2011;1:25(2):129-143. https://doi.org/10.2165/11586450-000000000-00000
  5. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Archives of General Psychiatry. 2003;60:1187-1192. https://doi.org/10.1001/archpsyc.60.12.1187
  6. Wray NR, Gottesman II. Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, & major depressive disorder. Frontiers in Genetics. 2012;3:118. https://doi.org/10.3389/fgene.2012.00118
  7. Franzek E, Beckmann H. Different genetic background of schizophrenia spectrum psychoses: a twin study. American Journal of Psychiatry. 1998;155:76-83. https://doi.org/10.1176/ajp.155.1.76
  8. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, Hultman ChM. Common genetic determinants of schizophrenia & bipolar disorder in Swedish families: a population-based study. Lancet. 2009;373:234-239. https://doi.org/10.1016/s0140-6736(09)60072-6
  9. Cardno AG, Gottesman II. Twin studies of schizophrenia: from bow-& arrow concordances to star wars Mx & functional genomics. American Journal of Medical Genetics. 2000;97:12-17. https://doi.org/10.1002/(sici)1096-8628(200021)97:1<12::aid-ajmg3>3.3.co;2-l
  10. Harrison PJ. Recent genetic findings in schizophrenia & their therapeutic relevance. Journal of Psychopharmacology. 2015;29(2):85-96. https://doi.org/10.1177/0269881114553647
  11. Kendler KS. A joint history of the nature of genetic variation & the nature of schizophreniа. Molecular Psychiatry. 2015;20:77-83. https://doi.org/10.1038/mp.2014.94
  12. Thibaut F. Schizophrenia: An example of complex genetic disease. World Journal of Biological Psychiatry. 2006;7:194-197. https://doi.org/10.1080/15622970600994313
  13. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology & strategic intentions. American Journal of Psychiatry. 2003;160:636-645. https://doi.org/10.1176/appi.ajp.160.4.636
  14. Chamberlain SR, Menzies L. Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential. Expert review of neurotherapeutics. 2009;9(8):1133-1146. https://doi.org/10.1586/ern.09.36
  15. Owens EM, Bachman P, Glahn DC, Bearden CE. Electrophysiological endophenotypes for schizophrenia. Harvard Review of Psychiatry. 2016;24:129-147. https://doi.org/10.1097/HRP.0000000000000110
  16. Thaker GK, Avila MT, Hong EL, Medoff DR, Ross DE, Adami HM. A model of smooth pursuit eye movement deficit associated with the schizophrenia phenotype. Psychophysiology. 2003;40(2):277-284. https://doi.org/10.1111/1469-8986.00029
  17. Biscotti MA, Olmo E, Heslop-Harrison JS. Repetitive DNA in eukaryotic genomes. Chromosome Research. 2015;23(3):415-420. https://doi.org/10.1007/s10577-0159499-z
  18. Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, Findling RL, Sikich L, Stromberg T, Merriman B, Gogtay N, Butler P, Eckstrand K, Noory L, Gochman P, Long R, Chen Z, Davis S, Baker C, Eichler EE, Meltzer PS, Nelson SF, Singleton AB, Lee MK, Rapoport JL, King MC, Sebat J. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science. 2008;25:320(5875):539-543. https://doi.org/10.1126/science.1155174
  19. Wolff RY, Nakamura S, Odelberg R, Shiang R. Generation of variability at VNTR loci in human DNA. DNA Fingerprinting: Approaches and Applications. 1991.
  20. Shastry BS. Copy number variation & susceptibility to human disorders. Molecular Medicine Report. 2009;2:143-147. https://doi.org/10.3892/mmr_00000074
  21. Patel A, Cheung SW. Application of DNA microarray to clinical diagnostics. Methods in Molecular Biology. 2016;1368:111-132. https://doi.org/10.1007/978-1-4939-3136-1_9
  22. Avramopoulos D. Genetics of psychiatric disorders methods: molecular approaches. Psychiatric Clinics of North America. 2010;33(1):1-13. https://doi.org/10.1016/j.psc.2009.12.006
  23. Cookson W, Liang L, Abecasis G, Moffatt M, Lathrop M. Mapping complex disease traits with global gene expression. Nature Reviews Genetics. 2009;10(3):184-194. https://doi.org/10.1038/nrg2537
  24. Lencz T, Morgan TV, Athanasiou M, Dain B, Reed CR, Kane JM, Kucherlapati R, Malhotra AK. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Molecular Psychiatry. 2007;12:572-580. https://doi.org/10.1038/sj.mp.4001983
  25. Sullivan PF, Lin D, Tzeng JY, van den Oord E, Perkins D, Stroup TS, Wagner M, Lee S, Wright FA, Zou F. Genomewide association for schizophrenia in the CATIE study: results of stage 1. Molecular Psychiatry. 2008;13:570-584. https://doi.org/10.1038/mp.2008.25
  26. O’Donovan MC, Craddock N, Norton N, et al. Identification of loci associated with schizophrenia by genome-wide association & follow-up. Nature Genetics. 2008;40:1053-1055. https://doi.org/10.1038/ng.201
  27. Ripke S, Kenneth A, Kendler S, Levinson D, Sklar P, Holmans P, Lin D-Y, Ophoff RA, Andreassen OA, Scolnick E, Cichon S, Clair DSt, Corvin A, Gurling H, Werge T, Rujescu D, Blackwood D, Pato C, Malhotra A, Purcell S, Dudbridge F, Neale BM, Rossin L, Visscher P. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci. Nature Genetics. 2011;18:43:969-976. https://doi.org/10.1038/ng.940
  28. Gurung R, Prata DP. What is the impact of genome-wide supported risk variants for schizophrenia & bipolar disorder on brain structure & function? A systematic review. Psychological Medicine. 2015;45(12):2461-2480. https://doi.org/10.1017/s0033291715000537
  29. Hess JL, Glatt SJ. How might ZNF804A variants influence risk for schizophrenia & bipolar disorder? A literature review, synthesis, & bioinformatic analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2014;165B(1):28-40. https://doi.org/10.1002/ajmg.b.32207
  30. Guella I, Sequeira A, Rollins B, Morgan L, Myers RM, Watson SJ, Akil H, Bunney WE, DeLisi LE, Byerley W, Vawter MP. Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex. Schizophrenia Research. 2014;152(1):111-116. https://doi.org/10.1016/j.schres.2013.11.021
  31. Hill MJ, Bray NJ. Allelic differences in nuclear protein binding at a genome-wide significant risk variant for schizophrenia in ZNF804A. Molecular Psychiatry. 2011;16(8):787-789. https://doi.org/10.1038/mp.2011.21
  32. Bigos KL, Mattay VS, Callicott JH, Straub RE, Radhakrishna Vakkalanka, Bhaskar Kolachana, Hyde ThM, Lipska BK, Kleinman JE, Weinberger DR. Genetic variation in CACNA1C affects brain circuitries related to mental illness. Archives of General Psychiatry. 2010;67(9):939-945. https://doi.org/10.1001/archgenpsychiatry.2010.96
  33. Cross-Disorder Group of the Psychiatric Genomics. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics. 2013;45:984-994. https://doi.org/10.1038/ng.2711
  34. Levine J. Risk loci with shared effects on major psychiatric disorders. The Lancet. 2013;382:307. https://doi.org/10.1016/s0140-6736(13)61632-3
  35. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421-427. https://doi.org/10.1038/nature13595
  36. 3H MK-801 binding sites in postmortem brain regions of schizophrenic patients. Journal of Neural Transmission. 1989;77:231-236. https://doi.org/10.1007/bf01248936
  37. Hashimoto K. Blood D-serine levels as a predictive biomarker for the rapid antidepressant effects of the NMDA receptor antagonist ketamine. Psychopharmacology. 2014;231(20):4081-4082. https://doi.org/10.1007/s00213-014-3735-7
  38. Hashimoto K, Fukushima T, Shimizu E. Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the Nmethyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Archives of General Psychiatry. 2003;60:572-576. https://doi.org/10.1001/archpsyc.60.6.572
  39. Tsai GE, Lin PY. Strategies to enhance N-methyl-Daspartate receptor-mediated neurotransmission in schizophrenia, a critical review & meta-analysis. Current Pharmaceutical Design. 2010;16:522-537. https://doi.org/10.2174/138161210790361452
  40. Doi N, Hoshi Y, Itokawa M, Yoshikawa T, Ichikawa T, Arai M, Usui C, Tachikawaet H. Paradox of schizophrenia genetics: is a paradigm shift occurring? Behavioral and Brain Functions. 2012;31:8-28. https://doi.org/10.1186/1744-9081-8-28
  41. Alfimova MV, Golimbet VE, Korovaytseva GI, Lezheyko TV, Abramova LI, Aksenova EV, Bolgov MI. The effect of the serotonin transporter 5-HTTLPR polymorphism on the recognition of facial emotions in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2014;114:1:42-47. (In Russ.) .
  42. Hagemeyer N, Goebbels S, Pariol S. A myelin gene causative of a catatonia-depression syndrome upon aging. EMBO Molecular Medicine. 2012;4(6): 528-539. https://doi.org/10.1002/emmm.201200230
  43. Zhai J, Yu Q, Chen M, et al. Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms & the cognitive function & clinical symptoms of schizophrenia. The International Journal of Clinical and Experimental Pathology. 2013;6(8):1617-1623.
  44. Kolesnichenko EV, Barylnik YB, Golimbet VE. Influence of BDNF gene on phenotypic expression of paranoid schizophrenia. Social and clinical psychiatry. 2015;25(2):45-49. (In Russ.) . и клиническая психиатрия. 2015;25(2):45-49.
  45. Alfimova MV, Kondratyev NV, Golimbet VE. Results and prospects of genetic studies of cognitive impairment in schizophrenia: Part. 2. Epigenetic approaches. Journal of Neurology and Psychiatry im. S.S. Korsakov. 2017;2: (In Russ.) .
  46. Sekar A, Bialas AR, de Rivera H. Avery Davis, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Vanessa Van Doren, Genovese G, Rose SA, Handsaker RE, Daly MJ, Carroll MC, Stevens B, McCarroll SA. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530:177-183. https://doi.org/10.1038/nature16549
  47. Mirnics K, Middleton FA, Lewis DA, Levitt P. Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends in Neuroscience. 2001;24:479-486. https://doi.org/10.1016/s01662236(00)01862-2
  48. Falkai P. A desperate search for biomarkers in schizophrenia. What is going wrong? World Psychiatry. 2011;10(1):38-39. https://doi.org/10.1002/j.2051-5545.2011.tb00011.x
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