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Morozova A.Yu.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zubkov E.A.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zorkina Ia.A.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo"

Reznik A.M.

Gosudarstvennyĭ institut usovershenstvovaniia vracheĭ Ministerstva oborony RF, Moskva

Kostyuk G.P.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Chekhonin V.P.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo";
Kafedra meditsinskikh nanobiotekhnologiĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova

Genetic aspects of schizophrenia

Authors:

Morozova A.Yu., Zubkov E.A., Zorkina Ia.A., Reznik A.M., Kostyuk G.P., Chekhonin V.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(6): 126‑132

DOI: 10.17116/jnevro201711761126-132

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To cite this article:

Morozova AYu, Zubkov EA, Zorkina IaA, Reznik AM, Kostyuk GP, Chekhonin VP. Genetic aspects of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(6):126‑132. (In Russ.)
https://doi.org/10.17116/jnevro201711761126-132

 
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Schizophrenia is a disease with a complex non-Mendelian inheritance mechanism in most cases involving the combined action of a large number of genes. Identifying of genomic variations associated with schizophrenia endophenotypes has a great potential. This review describes genetic markers of the disease, current methods of their analysis, including genome-wide association study (GWAS). Certain genes with mutations that increase the risk of schizophrenia are described. Functional polymorphisms with phenotypic expression, which are significantly associated with clinical manifestation of schizophrenia, can serve as useful genetic markers. The authors highlight that currently there are no certain susceptibility genes. Further global research and search for markers in different population groups are needed.

Keywords:

schizofrenia
genetics
endofenotypes
genetic markers

Authors:

Morozova A.Yu.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zubkov E.A.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Zorkina Ia.A.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo"

Reznik A.M.

Gosudarstvennyĭ institut usovershenstvovaniia vracheĭ Ministerstva oborony RF, Moskva

Kostyuk G.P.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Chekhonin V.P.

Otdel fundamental'noĭ i prikladnoĭ neĭrobiologii FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo";
Kafedra meditsinskikh nanobiotekhnologiĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta im. N.I. Pirogova

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