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Azimova Yu.E.

University Clinic LLC;
Research Institute of General Pathology and Pathophysiology

Skorobogatykh K.V.

University Clinic LLC

Rudko O.I.

Lomonosov Moscow State University

Ostroukhova I.O.

Lomonosov Moscow State University

Nefedova L.N.

Lomonosov Moscow State University

Kukushkin M.L.

Research Institute of General Pathology and Pathophysiology

Diagnosis and treatment of cluster headache: a differentiated clinical and genetic approach

Authors:

Azimova Yu.E., Skorobogatykh K.V., Rudko O.I., Ostroukhova I.O., Nefedova L.N., Kukushkin M.L.

More about the authors

Journal: Russian Journal of Pain. 2025;23(3): 11‑16

DOI: 10.17116/pain20252303111

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Table of contents

DIAGNOSIS AND TREATMENT OF CLUSTER HEADACHE: A DIFFERENTIATED CLINICAL AND GENETIC APPROACH
DIAGNOSIS AND TREATMENT OF CLUSTER HEADACHE: A DIFFERENTIATED CLINICAL AND GENETIC APPROACH

To cite this article:

Azimova YuE, Skorobogatykh KV, Rudko OI, Ostroukhova IO, Nefedova LN, Kukushkin ML. Diagnosis and treatment of cluster headache: a differentiated clinical and genetic approach. Russian Journal of Pain. 2025;23(3):11‑16. (In Russ.)
https://doi.org/10.17116/pain20252303111

Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The role of algogenic peptides — pituitary adenylate cyclase activating polypeptide (PACAP) and calcitonin gene-related peptide (CGRP) — is actively studied in cluster headache (CH). The aim of the study was to investigate genetic biomarkers of CH within the CGRP system, as well as clinical and genetic characteristics of patients sensitive and insensitive to verapamil therapy. The retrospective clinical analysis included 61 patients (48 men and 13 women) with CH, the average age was 39.3±12.2 (19—71) years. Episodic CH was suffered by 46 (75.4%) patients, chronic CH — by 15 (24.6%) patients. The genetic study included 23 patients of the main group. Patients with CH are characterized by the GG variant of RAMP1 rs7590387, as well as GT or TT variants of CSE rs1021737, CT variant of CGRP rs155209, AA variant of CSE rs482843. The RAMP1 rs7590387 CC genotype was noted in 12.5±3.4% of patients with migraine symptoms during an attack of CH, and in 57.1±5.3% of patients without migraine symptoms (p=0.004). In patients with sensitivity to verapamil, CH had an episodic form, the clinical picture was characterized by a pulsating nature of pain, with attacks occurring only at night, RAMP1 rs7590387 GC polymorphism was not detected.

Keywords:

cluster headache
genetics
verapamil

Authors:

Azimova Yu.E.

University Clinic LLC;
Research Institute of General Pathology and Pathophysiology

Skorobogatykh K.V.

University Clinic LLC

Rudko O.I.

Lomonosov Moscow State University

Ostroukhova I.O.

Lomonosov Moscow State University

Nefedova L.N.

Lomonosov Moscow State University

Kukushkin M.L.

Research Institute of General Pathology and Pathophysiology

Received:

09.05.2025

Accepted:

11.07.2025

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