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Karlov V.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Gekht A.B.

N.I. Pirogov Russian State Medical University

Guzeva V.I.

Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

Lipatova L.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, Sankt-Peterburg

Bazilevich S.N.

Kafedra i klinika nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Mkrtchyan V.R.

Soloviev Scientific-Practical Psycho-Neurological Сenter, Moscow, Russia

Vlasov P.N.

GBUZ MO "Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii", Moskva

Zhidkova I.A.

Kafedra nervnykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Mukhin K.Iu.

Kafedra nervnykh bolezneĭ pediatricheskogo fakul'teta s kursom fakul'teta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Petrukhin A.S.

Kafedra nervnykh bolezneĭ pediatricheskogo fakul'teta s kursom fakul'teta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Lebedeva A.V.

FGBU "Federal'nyĭ nauchnyĭ tsentr transplantologii i iskusstvennykh organov im. akad. V.I. Shumakova" Minzdrava Rossii, Moskva

Algorithms of mono- and polytherapy in clinical epileptology

Authors:

Karlov V.A., Gekht A.B., Guzeva V.I., Lipatova L.V., Bazilevich S.N., Mkrtchyan V.R., Vlasov P.N., Zhidkova I.A., Mukhin K.Iu., Petrukhin A.S., Lebedeva A.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(7): 120‑129

DOI: 10.17116/jnevro201611671120-129

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Table of contents

ALGORITHMS OF MONO- AND POLYTHERAPY IN CLINICAL EPILEPTOLOGY
ALGORITHMS OF MONO- AND POLYTHERAPY IN CLINICAL EPILEPTOLOGY

To cite this article:

Karlov VA, Gekht AB, Guzeva VI, et al. . Algorithms of mono- and polytherapy in clinical epileptology. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(7):120‑129. (In Russ.)
https://doi.org/10.17116/jnevro201611671120-129

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

The large number of antiepileptic drugs (AEDs) at the physician's disposal provides not only a broad therapeutic potential in the treatment of epilepsy (EP), but creates difficulties in the adequate choice of AED. The sufficient experience in the management of patients with epilepsy has been gained so far in the world, based on which the International League Against Epilepsy (ILAE), updated classification, adopted the basic definition of efficiency, remission, resistance, evidence of research on the effectiveness of AED therapy, and introduced the concept of "resolved" epilepsy. In this article, a group of Russian experts suggest recommendations on the main steps in the choice of therapy in epilepsy. Possible drug interactions between different AEDs and other drugs as well as main characteristics of mono- and polytherapy of epilepsy are described. Some features of the use of AEDs in the elderly, characteristics of the "female" epilepsy related to the reproductive function and basic requirements for the therapy of epilepsy in children are presented.

Keywords:

epilepsy
mono- and polytherapy
drug-drug interactions
rational AED combinations

Authors:

Karlov V.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Gekht A.B.

N.I. Pirogov Russian State Medical University

Guzeva V.I.

Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

Lipatova L.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, Sankt-Peterburg

Bazilevich S.N.

Kafedra i klinika nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Mkrtchyan V.R.

Soloviev Scientific-Practical Psycho-Neurological Сenter, Moscow, Russia

Vlasov P.N.

GBUZ MO "Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii", Moskva

Zhidkova I.A.

Kafedra nervnykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Mukhin K.Iu.

Kafedra nervnykh bolezneĭ pediatricheskogo fakul'teta s kursom fakul'teta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Petrukhin A.S.

Kafedra nervnykh bolezneĭ pediatricheskogo fakul'teta s kursom fakul'teta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Lebedeva A.V.

FGBU "Federal'nyĭ nauchnyĭ tsentr transplantologii i iskusstvennykh organov im. akad. V.I. Shumakova" Minzdrava Rossii, Moskva

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