Neurotrophic peptides of сerebrolysin as a basis for anticonvulsant effect of the drug

Bonartsev P.D.; Rakhmanova V.I.; Uranova N.A.

doi:https://doi.org/10.17116/jnevro20161163149-54

Bonartsev P.D.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Rakhmanova V.I.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Neurotrophic peptides of сerebrolysin as a basis for anticonvulsant effect of the drug

Authors:

Bonartsev P.D., Rakhmanova V.I., Uranova N.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3): 49‑54

DOI: 10.17116/jnevro20161163149-54

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To cite this article:

Bonartsev PD, Rakhmanova VI, Uranova NA. Neurotrophic peptides of сerebrolysin as a basis for anticonvulsant effect of the drug. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3):49‑54. (In Russ.)
https://doi.org/10.17116/jnevro20161163149-54

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective — to study the effect of olanzapine on the ultrastructure of different populations of lymphocytes and lymphoblasts in patients with schizophrenia.

Material and methods. Authors performed a morphometric study using electron microscopy of lymphocytes in 56 patients with schizophrenia treated for 8 weeks with olanzapine and 49 patients treated for 28 weeks with olanzapine before and after treatment. Authors estimated the frequency and ultrastructural parameters of small, large, large activated lymphocytes and lymphoblasts.

Results. The frequency of small lymphocytes in patients treated with olanzapine increased and that of large lymphocytes decreased in treated patients as compared to the patients before treatment. The volume fraction of lysosomes increased significantly in small, large and large activated lymphocytes after treatment as compared to the patients before treatment.

Conclusion. The increased lysosome content in different lymphocyte subpopulations might contribute to the mechanism of olanzapine efficacy.

Keywords:

schizophrenia

lymphocyte

olanzapine

lysosomes

ultrastructure

morphometry

Authors:

Bonartsev P.D.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Rakhmanova V.I.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

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