Objective. To study the efficacy and tolerability of the drugs pantogam active and phenotropil in mild neurotic, somatoform, stress-induced and depressive disorders developed in patients with cardiovascular diseases. Material and methods. The effect of pantogam active was assessed in an open study. The main group of patients (n=35) treated with phenotropil during 12 weeks was compared to the comparison group (n=35). Patient's status was evaluated using psychometric (CGI, HDRS etc) and adverse effect scales. Results and сonclusion. Statistically significant results demonstrated the advantages of pantogam active has advantage on a number of values. The treatment effect of pantogam active gradually increased while the effect (in particular anxiolytic one) of phenotropil decreased after 4-8 weeks of treatment. The tolerability of both drugs was satisfactory.