The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Avdeeva K.S.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences;
Tyumen State Medical University

Redkina I.N.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences;
Tyumen State Medical University

Petelina T.I.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center of the Russian Academy of Science

Suplotova L.A.

Tyumen State Medical University

Gorbachevskii A.V.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences

Samoilova E.P.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences

Shapovalova E.M.

Tyumen State Medical University

Triglycerides-Glucose Index as an integral biomarker of insulin resistance and cardiovascular diseases

Authors:

Avdeeva K.S., Redkina I.N., Petelina T.I., Suplotova L.A., Gorbachevskii A.V., Samoilova E.P., Shapovalova E.M.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(5): 124‑129

DOI: 10.17116/profmed202528051124

Read: 1278 times

Buy for 300₽
Contact the author
Table of contents

TRIGLYCERIDES-GLUCOSE INDEX AS AN INTEGRAL BIOMARKER OF INSULIN RESISTANCE AND CARDIOVASCULAR DISEASES
TRIGLYCERIDES-GLUCOSE INDEX AS AN INTEGRAL BIOMARKER OF INSULIN RESISTANCE AND CARDIOVASCULAR DISEASES

To cite this article:

Avdeeva KS, Redkina IN, Petelina TI, Suplotova LA, Gorbachevskii AV, Samoilova EP, Shapovalova EM. Triglycerides-Glucose Index as an integral biomarker of insulin resistance and cardiovascular diseases. Russian Journal of Preventive Medicine. 2025;28(5):124‑129. (In Russ.)
https://doi.org/10.17116/profmed202528051124

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Risk factors and adve­rse outcomes of cardiovascular diseases in people with high normal blood pressure of the Ryazan region. (5-year prospective follow-up). Russian Journal of Preventive Medi­cine. 2025;(2):31-37
10-year dyna­mics of cardiovascular status in combination with coro­nary angiography data in men of working age in the Arctic region of resi­dence and the south of the Tyumen region. Russian Journal of Preventive Medi­cine. 2025;(4):30-38
Study of the levo­carnitine effi­cacy for the treatment of mode­rate cognitive impairment in patients with hype­rtension. Russian Journal of Preventive Medi­cine. 2025;(4):45-50
Sleep characterization — a marker of meta­bolic health: acti­graphy data. Russian Journal of Preventive Medi­cine. 2025;(5):69-74
Psoriasis: analysis of como­rbid pathology. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(1):16-21
Uveal mela­noma and its local inflammation — good or bad for the patient?. Russian Annals of Ophthalmology. 2025;(1):5-12
The role of some markers of the infe­ctious process in the early diagnosis and evaluation of the effe­ctiveness of anti­biotic therapy in obstetric sepsis. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):15-20
Modern aspe­cts of gestational diabetes mellitus: defi­nition, risk factors. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):35-41
Age-related pecu­liarities of blood para­meters in women and their impact on the outcome of in vitro fertilization programs. Russian Journal of Human Reproduction. 2025;(2):28-36
Prospects for treating Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):54-60
Abstract:

Given the growing number of people with insulin resistance and cardiovascular diseases (CVD), it is necessary to search for and justify the use of markers of these conditions to identify cardiometabolic risk factors as early as possible, as well as to treat and rehabilitate patients. The triglyceride-glucose index (TyG) can be considered an integral marker of insulin resistance and a CVD predictor.

OBJECTIVE OF THE REVIEW

To review the use of the triglyceride-glucose index in scientific research as an integral biomarker of insulin resistance and a predictor of cardiovascular diseases.

MATERIALS AND METHODS

Sources for the review article were searched and selected in the scientific databases eLibrary.ru, Link.Springer.com, PubMed.ncbi.nlm.nih.gov, Web of Science, and Google Scholar.

RESULTS

Several large studies have demonstrated that the TyG index can be regarded as a predictor of CVD development and used for the early detection of patients at high CVD risk. Among the biomarkers for CVD prediction in patients with type 2 diabetes, the TyG index showed a high predictive value with moderate significance and high reliability. This index can be considered an indicator of the severity of carbohydrate metabolism disorders and, in general, of cardiometabolic risk.

CONCLUSION

The TyG index is a simple and convenient tool for assessing insulin resistance. It is a promising tool that can improve the early diagnosis of cardiovascular diseases, but a deeper study of its properties and performance is needed.

Keywords:

insulin resistance
TyG index
glucose
triglycerides
cardiometabolic risk
biomarker
cardiovascular diseases

Authors:

Avdeeva K.S.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences;
Tyumen State Medical University

Redkina I.N.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences;
Tyumen State Medical University

Petelina T.I.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center of the Russian Academy of Science

Suplotova L.A.

Tyumen State Medical University

Gorbachevskii A.V.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences

Samoilova E.P.

Tyumen Cardiology Research Center — Tomsk National Research Medical Center Russian Academy of Sciences

Shapovalova E.M.

Tyumen State Medical University

Received:

08.02.2025

Accepted:

17.03.2025

Close metadata

References:

  1. Placzkowska S, Pawlik-Sobecka L, Kokot I, et al. Indirect insulin resistance detection: Current clinical trends and laboratory limitations. Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2019;163(3):187-199.  https://doi.org/10.5507/bp.2019.021
  2. Sotiropoulos C, Giormezis N, Pertsas V, et al. Biomarkers and Data Visualization of Insulin Resistance and Metabolic Syndrome: An Applicable Approach. Life (Basel). 2024;14(9):1197. https://doi.org/10.3390/life14091197
  3. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595-1607. https://doi.org/10.2337/diab.37.12.1595
  4. Bodaghi A, Fattahi N, Ramazani A. Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases. Heliyon. 2023;9(2):e13323. https://doi.org/10.1016/j.heliyon.2023.e13323
  5. Freeman AM, Acevedo LA, Pennings N. Insulin Resistance. 2023 Aug 17. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan. 
  6. Yaribeygi H, Farrokhi FR, Butler AE, et al. Insulin resistance: Review of the underlying molecular mechanisms. Journal of Cellular Physiology. 2019; 234(6):8152-8161. https://doi.org/10.1002/jcp.27603
  7. Caturano A, Vetrano E, Galiero R, et al. Advances in the Insulin-Heart Axis: Current Therapies and Future Directions. International Journal of Molecular Sciences. 2024;25(18):10173. https://doi.org/10.3390/ijms251810173
  8. Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. Journal of Clinical Investigation. 2016;126(1):12-22.  https://doi.org/10.1172/JCI77812
  9. Ormazabal V, Nair S, Elfeky O, et al. Association between insulin resistance and the development of cardiovascular disease. Cardiovascular Diabetology. 2018;17(1):122.  https://doi.org/10.1186/s12933-018-0762-4
  10. Scott DA, Ponir C, Shapiro MD, et al. Associations between insulin resistance indices and subclinical atherosclerosis: A contemporary review. American Journal of Preventive Cardiology. 2024;18:100676. https://doi.org/10.1016/j.ajpc.2024.100676
  11. Rafiee H, Mohammadifard N, Nouri F, et al. Association of triglyceride glucose index with cardiovascular events: insights from the Isfahan Cohort Study (ICS). European Journal of Medical Research. 2024;29(1):135.  https://doi.org/10.1186/s40001-024-01728-4
  12. Cersosimo E, Solis-Herrera C, Trautmann ME, et al. Assessment of pancreatic β-cell function: review of methods and clinical applications. Current Diabetes Reviews. 2014;10(1):2-42.  https://doi.org/10.2174/1573399810666140214093600
  13. Minh HV, Tien HA, Sinh CT, et al. Assessment of preferred methods to measure insulin resistance in Asian patients with hypertension. Journal of Clinical Hypertension (Greenwich, Conn.). 2021;23(3):529-537.  https://doi.org/10.1111/jch.14155
  14. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metabolic Syndrome and Related Disorders. 2008;6(4):299-304.  https://doi.org/10.1089/met.2008.0034
  15. Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. Journal of Clinical Endocrinology and Metabolism. 2010;95(7):3347-3351. https://doi.org/10.1210/jc.2010-0288
  16. Alizargar J, Hsieh NC, Wu SV. The correct formula to calculate triglyceride-glucose index (TyG). Journal of Pediatric Endocrinology and Metabolism. 2020;33(7):945-946.  https://doi.org/10.1515/jpem-2019-0579
  17. Kurniawan LB. Triglyceride-Glucose Index as a Biomarker of Insulin Resistance, Diabetes Mellitus, Metabolic Syndrome, and Cardiovascular Disease: A Review. EJIFCC. 2024;35(1):44-51. 
  18. Sánchez-García A, Rodríguez-Gutiérrez R, Mancillas-Adame L, et al. Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review. International Journal of Endocrinology. 2020; 2020:4678526. https://doi.org/10.1155/2020/4678526
  19. Son DH, Lee HS, Lee YJ, et al. Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome. Nutrition, Metabolism, and Cardiovascular Diseases. 2022;32(3):596-604.  https://doi.org/10.1016/j.numecd.2021.11.017
  20. Wan H, Cao H, Ning P. Superiority of the triglyceride glucose index over the homeostasis model in predicting metabolic syndrome based on NHANES data analysis. Scientific Reports. 2024;14(1):15499. https://doi.org/10.1038/s41598-024-66692-9
  21. Paramanathan T, Sandrasegarampillai B, Arasaratnam V, et al. The discriminative ability of the triglyceride-glucose index to identify metabolic syndrome among adults of the northern Sri Lankan population. BMC Endocrine Disorders. 2024;24(1):101.  https://doi.org/10.1186/s12902-024-01632-2
  22. Couto AN, Pohl HH, Bauer ME, et al. Accuracy of the triglyceride-glucose index as a surrogate marker for identifying metabolic syndrome in non-diabetic individuals. Nutrition. 2023;109:111978. https://doi.org/10.1016/j.nut.2023.111978
  23. Dundar C, Terzi O, Arslan HN. Comparison of the ability of HOMA-IR, VAI, and TyG indexes to predict metabolic syndrome in children with obesity: a cross-sectional study. BMC Pediatrics. 2023;23(1):74.  https://doi.org/10.1186/s12887-023-03892-8
  24. Brito ADM, Hermsdorff HHM, Filgueiras MS, et al. Predictive capacity of triglyceride-glucose (TyG) index for insulin resistance and cardiometabolic risk in children and adolescents: a systematic review. Critical Reviews in Food Science and Nutrition. 2021;61(16):2783-2792. https://doi.org/00.1080/10408398.2020.1788501
  25. Kim MK, Ahn CW, Kang S, et al. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovascular Diabetology. 2017;16(1):108.  https://doi.org/10.1186/s12933-017-0589-4
  26. Irace C, Carallo C, Scavelli FB, et al. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. International Journal of Clinical Practice. 2013;67(7):665-672.  https://doi.org/10.1111/ijcp.12124
  27. Wang S, Shi J, Peng Y, et al. Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study. Cardiovascular Diabetology. 2021; 20(1):82.  https://doi.org/10.1186/s12933-021-01274-x
  28. Ruyatkina LA, Ruyatkin DS, Iskhakova IS. Opportunities and options for surrogate assessment of insulin resistance. Ozhirenie i metabolizm. 2019;16(1):27-33. (In Russ.). https://doi.org/10.14341/omet10082
  29. Fazio S, Bellavite P, Affuso F. Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer. Biomedicines. 2024;12(10):2416. https://doi.org/10.3390/biomedicines12102416
  30. Ahmad A, Lim LL, Morieri ML, et al. Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis. Communications Medicine. 2024;4(1):11.  https://doi.org/10.1038/s43856-023-00429-z
  31. Sun Y, Ji H, Sun W, et al. Triglyceride glucose (TyG) index: A promising biomarker for diagnosis and treatment of different diseases. European Journal of Internal Medicine. 2024;2024:S0953-6205(24)00375-3.  https://doi.org/10.1016/j.ejim.2024.08.026
  32. Sánchez-Íñigo L, Navarro-González D, Fernández-Montero A, et al. The TyG index may predict the development of cardiovascular events. European Journal of Clinical Investigation. 2016;46(2):189-197.  https://doi.org/10.1111/eci.12583
  33. Li S, Guo B, Chen H, et al. The role of the triglyceride (triacylglycerol) glucose index in the development of cardiovascular events: a retrospective cohort analysis. Scientific Reports. 2019;9(1):7320. https://doi.org/10.1038/s41598-019-43776-5
  34. Barzegar N, Tohidi M, Hasheminia M, et al. The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study. Cardiovascular Diabetology. 2020;19(1):155.  https://doi.org/10.1186/s12933-020-01121-5
  35. Mirshafiei H, Darroudi S, Ghayour-Mobarhan M, et al. Altered triglyceride glucose index and fasted serum triglyceride high-density lipoprotein cholesterol ratio predict incidence of cardiovascular disease in the Mashhad cohort study. Biofactors. 2022;48(3):643-650.  https://doi.org/10.1002/biof.1816
  36. Hong S, Han K, Park CY. The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study. BMC Medicine. 2020;18(1):361.  https://doi.org/10.1186/s12916-020-01824-2
  37. Yang C, Song Y, Wang P. Relationship between triglyceride-glucose index and new-onset hypertension in general population-a systemic review and meta-analysis of cohort studies. Clinical and Experimental Hypertension. 2024;46(1):2341631. https://doi.org/10.1080/10641963.2024.2341631
  38. Lukito AA, Kamarullah W, Huang I, et al. Association between triglyceride-glucose index and hypertension: A systematic review and meta-analysis. Narra Journal. 2024;4(2):e951. https://doi.org/10.52225/narra.v4i2.951
  39. Azarboo A, Behnoush AH, Vaziri Z, et al. Assessing the association between triglyceride-glucose index and atrial fibrillation: a systematic review and meta-analysis. European Journal of Medical Research. 2024;29(1):118.  https://doi.org/10.1186/s40001-024-01716-8
  40. Luo JW, Duan WH, Yu YQ, et al. Prognostic Significance of Triglyceride-Glucose Index for Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis. Frontiers in Cardiovascular Medicine. 2021;8:774781. https://doi.org/10.3389/fcvm.2021.774781
  41. Yan Y, Wang D, Sun Y, et al. Triglyceride-glucose index trajectory and arterial stiffness: results from Hanzhong Adolescent Hypertension Cohort Study. Cardiovascular Diabetology. 2022;21(1):33.  https://doi.org/10.1186/s12933-022-01453-4
  42. Lee SB, Ahn CW, Lee BK, et al. Association between triglyceride glucose index and arterial stiffness in Korean adults. Cardiovascular Diabetology. 2018;17(1):41.  https://doi.org/10.1186/s12933-018-0692-1
  43. Wu S, Xu L, Wu M, et al. Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study. Cardiovascular Diabetology. 2021; 20(1):146.  https://doi.org/10.1186/s12933-021-01342-2
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.