The state of the human cardiovascular system reflects the degree of body adaptation to the effects of the Arctic’s natural and climatic factors. Changes in the parameters of cardiovascular status, including the state of the coronary bed of Arctic residents induced by adverse environmental factors, should be the subject of study. This is especially relevant for assessing the health status of men of working age, as they are the most vulnerable gender group in terms of cardiovascular complications.

OBJECTIVE

To analyze the 10-year trend of clinical, laboratory, and echocardiographic parameters and the results of coronary angiography in men living in the Arctic region and in the south of the Tyumen region.

MATERIALS AND METHODS

The study used data from the Register of Coronary Angiography Procedures, from which male patients who underwent angiography more than once from 1998 to 2022 were selected. Two groups were formed: 104 residents of Tyumen and the south of the Tyumen region and 111 residents of the Yamalo-Nenets Autonomous District. The groups were compared at baseline and after 10.0±2.8 years of follow-up; intra-group change of parameters was assessed.

RESULTS

Despite the initial comparability of the groups in terms of the prevalence of cardiovascular risk factors, in males living in the Arctic region, the severity of heart failure increased over time (p<0.001), the frequency of myocardial infarctions (p<0.001), multivascular (p=0.004) and occlusive lesion rate increased (p=0.041), as well as the aortic root indices (p=0.007), the left ventricular end-diastolic dimension (p=0.014), and the left ventricular mass increased (p=0.002).

CONCLUSION

In males of working age living in the Yamalo-Nenets Autonomous District, in the absence of initial differences in the frequency of cardiovascular risk factors, initially and after 10 years, more severe manifestations of coronary atherosclerosis were detected compared to males living in the south of the Tyumen region.