Objective: To study an effect of cortexin on epilepsy course and electroencephalographic pattern in stopping the symptoms concomitant to epilepsy. Material and methods: A study included 64 patients with epilepsy (22 men and 42 women, aged from 20 to 85 years). Along with standard treatment, the patients received cortexin (three 10-day courses during 12 months intramuscular in dose 10 mg daily). Results and Conclusion: There were the significant decrease in the frequency of seizures and the absence of failure of remission, the positive dynamics of electroencephalographic pattern as well as stopping of such symptoms as headache, non-systemic vertigo, asthenia, cognitive impairment, anxiety and depression, arterial hypertension.